Patents by Inventor Michael P. Trova
Michael P. Trova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9289434Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: December 18, 2014Date of Patent: March 22, 2016Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke UniversityInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20150231150Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: December 18, 2014Publication date: August 20, 2015Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 8946202Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: September 5, 2013Date of Patent: February 3, 2015Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke UniversityInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20140011794Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: September 5, 2013Publication date: January 9, 2014Applicants: Aeouls Sciences, Inc., Duke University, National Jewish HealthInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 8546562Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: April 26, 2012Date of Patent: October 1, 2013Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20120214780Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicants: AEOLUS SCIENCES, INC., DUKE UNIVERSITY, NATIONAL JEWISH HEALTHInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 8217026Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: September 17, 2010Date of Patent: July 10, 2012Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke UniversityInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20110065679Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: September 17, 2010Publication date: March 17, 2011Applicant: Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 7820644Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 16, 2006Date of Patent: October 26, 2010Assignee: Aelous Pharmaceuticals, Inc.Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 7470677Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 9, 2003Date of Patent: December 30, 2008Assignee: Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 7189707Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: January 23, 2003Date of Patent: March 13, 2007Assignees: National Jewish Medical Research Center, Duke University, Aeolus Sciences, Inc.Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20040023941Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: January 23, 2003Publication date: February 5, 2004Applicants: NATIONAL JEWISH MEDICAL AND RESEARCH CENTER, AEOLUS PHARMACEUTICALS, INC., DUKE UNIVERSITYInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Publication number: 20040019031Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: ApplicationFiled: June 9, 2003Publication date: January 29, 2004Applicants: DUKE UNIVERSITY, UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, AEOLUS PHARMACEUTICALS, INC.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 6583132Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: November 30, 1998Date of Patent: June 24, 2003Assignees: Duke University, University of Alabama at Birmingham Research Foundation, Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 6544975Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: January 25, 2000Date of Patent: April 8, 2003Assignees: National Jewish Medical and Research Center, Aeolus Pharmaceuticals INC, Duke UniversityInventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
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Patent number: 6479477Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.Type: GrantFiled: April 23, 1999Date of Patent: November 12, 2002Assignees: Duke University, Aeolus Pharmaceuticals, Inc.Inventors: James D. Crapo, Brian J. Day, Polivina Jolicia F. Gauuan, Anthony D. Pechulis, Jr., Michael P. Trova
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Patent number: 6127356Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: June 7, 1996Date of Patent: October 3, 2000Assignee: Duke UniversityInventors: James D. Crapo, Irwin Fridovich, Tim Oury, Brian J. Day, Rodney J. Folz, Bruce A. Freeman, Michael P. Trova, Ines Batinic-Haberle
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Patent number: 5914327Abstract: This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3)alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which may taken together to form a 4- to 7-membered ring;(C) R.sub.3 is selected from H, --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) X is located at the 2-, or 3-position and is selected from the group consisting of 2-naphthyl, 1-naphthyl, 1-phenanthrenyl, 2-phenanthrenyl, 3-phenanthrenyl, 4-phenanthrenyl, 9-phenanthrenyl, phenyl, and mono- or polysubstituted phenyl wherein the substituents are selected from the group consisting of --OR.sub.4, --NR.sub.5 R.sub.6, (C.sub.1 -C.sub.3) alkyl, --CF.sub.3, F, Cl, Br, I, --NO.sub.2, --CN, --SO.sub.3 H, --SO.sub.2 NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, and phenyl;R.sub.4 is H or (C.sub.1 -C.sub.Type: GrantFiled: November 6, 1997Date of Patent: June 22, 1999Assignee: American Cyanamid CompanyInventors: Michael P. Trova, Nan Zhang, Douglas B. Kitchen
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Patent number: 5908840Abstract: This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.Type: GrantFiled: November 6, 1997Date of Patent: June 1, 1999Assignee: American Cyanamid CompanyInventors: Michael P. Trova, Nan Zhang
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Patent number: 5569762Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.Type: GrantFiled: March 22, 1995Date of Patent: October 29, 1996Assignee: American Cyanamid CompanyInventors: Allan Wissner, Michael P. Trova