Patents by Inventor Michael P. Trova

Michael P. Trova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asymmetric synthesis of bicyclic amino acid esters
    Patent number: 5470979
    Abstract: The invention is an improved process for producing an optically active compound of formula IV: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are herein described. The improved process to produce a compound of formula IV comprises:a). reacting a diene with a chiral compound, containing a chiral auxiliary to obtain an olefinic compound;b). removing the chiral auxiliary and reducing the olefin by hydrogenation to obtain a compound of formula IV.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: November 28, 1995
    Assignee: American Cyanamid Company
    Inventor: Michael P. Trova
  • Retroviral protease inhibitors
    Patent number: 5430150
    Abstract: Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Robert E. Babine, Nan Zhang, Steven R. Schow, Allan Wissner
  • Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
    Patent number: 5428167
    Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: June 27, 1995
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Michael P. Trova
  • Aryl pyridinium compounds which are useful in treating shock
    Patent number: 5328921
    Abstract: The invention is aryl, amide, imide and carbamate pyridine antagonists of platelet activating factor.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: July 12, 1994
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Allan Wissner
  • Process for the preparation of 3'- or 2'-halo-substituted-2',3'-dideoxynucleosides
    Patent number: 5231175
    Abstract: A process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a transition metal or lanthanide compound.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: July 27, 1993
    Assignee: American Cyanamid Company
    Inventors: Kenneth E. Green, David M. Blum, Michael P. Trova
  • Pyridinium compounds which are useful as antagonists of platelet activating factor
    Patent number: 5208247
    Abstract: The invention is aryl, amide, imide and carbamate pyridine antagonists of platelet activating factor.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: May 4, 1993
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Allan Wissner