Patents by Inventor Michael Pawlak

Michael Pawlak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8380020
    Abstract: The planar optical structure forms an evanescent-field measuring platform. A body is made from the thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The planar optical structure forming an evanescent-field measuring platform has a first essentially optically transparent, waveguiding layer (a) with a refractive index n1 and a second essentially optical transparent layer (b) with refractive index n2, where n1>n2, in a case of an embodiment of a planar optical film waveguide, or a metal layer (a?) and a second layer (b), in a case of an embodiment for generating a surface plasmon resonance, wherein the second layer (b) includes a material from a group of cyclo-olefin polymers and cyclo-olefin copolymers.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: February 19, 2013
    Assignees: Weidmann Plastics Technology AG, Bayer Intellectual Property GmbH
    Inventors: Tilo Callenbach, Max Gmür, Heinz Lüthi, Martin Andreas Bopp, Michael Pawlak, Markus Ehrat
  • Patent number: 8053225
    Abstract: A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: November 8, 2011
    Assignee: Bayer Technology Services GmbH
    Inventors: Eveline Schürmann-Mader, Andreas Peter Abel, Martin Andreas Bopp, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Michael Pawlak, Nania Graciela Schärer-Hernández, Eginhard Schick
  • Patent number: 8034395
    Abstract: The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 ??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 ??(IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: October 11, 2011
    Assignee: Bayer Technology Services GmbH
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Patent number: 7955837
    Abstract: The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.
    Type: Grant
    Filed: October 29, 2005
    Date of Patent: June 7, 2011
    Assignee: Bayer Technology Services GmbH
    Inventors: Michael Pawlak, Eginhard Schick, Miro Venturi, Markus Ehrat
  • Patent number: 7927868
    Abstract: A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: April 19, 2011
    Assignee: Bayer Technology Services GmbH
    Inventors: Andreas Peter Abel, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Michael Pawlak, Eveline Schürmann-Mader
  • Patent number: 7879598
    Abstract: The invention relates to embodiments of an optical system for luminescence determination, comprising two or more excitation light sources, a sensor platform and an optical component with several discrete facets for beam deflection towards the sensor platform. Further subjects of the invention are methods for luminescence determination with an optical system according to the invention and analytical systems, as well as the use of these methods for quantitative affinity sensing and for various other applications. The aim of the present invention is to provide optical and analytical measuring devices for highly sensitive detection of one or more analytes, using a multitude of measurement areas on a common carrier.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: February 1, 2011
    Assignee: Bayer Technology Services GmbH
    Inventors: Wolfgang Zesch, Martin Andreas Bopp, Michael Pawlak
  • Publication number: 20100292098
    Abstract: The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 18, 2010
    Inventors: Michael PAWLAK, Eginhard SCHICK, Miro VENTURI, Markus EHRAT
  • Publication number: 20100280601
    Abstract: The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 ??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 ??(IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 4, 2010
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Publication number: 20100255461
    Abstract: The present invention relates to a method for manufacture a body from a thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The invention also relates to bodies manufactured with this method from a thermoplastic featuring a three-dimensionally structured surface, as well as to planar optical structures likewise manufactured with this method for generating evanescent-field measuring platforms and to a use thereof.
    Type: Application
    Filed: June 21, 2010
    Publication date: October 7, 2010
    Inventors: Tilo CALLENBACH, Max Gmür, Heinz Lüthi, Martin Andreas Bopp, Michael Pawlak, Markus Ehrat
  • Publication number: 20100227773
    Abstract: A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement.
    Type: Application
    Filed: March 17, 2010
    Publication date: September 9, 2010
    Inventors: Andreas Peter Abel, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Michael Pawlak, Eveline Schürmann-Mader
  • Patent number: 7767131
    Abstract: The present invention relates to a method for manufacture a body from a thermoplastic plastic with a three-dimensionally structured surface, wherein molding is performed directly from a master made of glass coated with metal oxide, without deposition of further coatings on a surface of the master. The invention also relates to bodies manufactured with this method from a thermoplastic featuring a three-dimensionally structured surface, as well as to planar optical structures likewise manufactured with this method for generating evanescent-field measuring platforms and to a use thereof.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: August 3, 2010
    Assignees: Bayer Technology Services GmbH, Weidmann Plastics Technology AG
    Inventors: Tilo Callenbach, Max Gmür, Heinz Lüthi, Martin Andreas Bopp, Michael Pawlak, Markus Ehrat
  • Patent number: 7740896
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 22, 2010
    Assignee: Bayer Technology Services GmbH
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Publication number: 20100130370
    Abstract: A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents.
    Type: Application
    Filed: January 28, 2010
    Publication date: May 27, 2010
    Inventors: Eveline Schurmann-Mader, Andreas Peter Abel, Martin Andreas Bopp, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Mtthias Kresbach, Michael Pawlak, Nania Graciela Scharer-Hernandez, Eginhard Schick
  • Patent number: 7708945
    Abstract: A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: May 4, 2010
    Assignee: Bayer Technology Services GmbH
    Inventors: Andreas Peter Abel, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Michael Pawlak, Eveline Schürmann-Mader
  • Patent number: 7678565
    Abstract: A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: March 16, 2010
    Assignee: Bayer Technology Services GmbH
    Inventors: Eveline Schürmann-Mader, Andreas Peter Abel, Martin Andreas Bopp, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Michael Pawlak, Nania Graciela Schärer-Hernández, Eginhard Schick
  • Patent number: 7645612
    Abstract: The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences gen
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: January 12, 2010
    Assignee: Bayer Technology Services GmbH
    Inventors: Michael Pawlak, Eginhard Schick, Andreas Peter Abel, Gert Ludwig Duveneck, Markus Ehrat, Gerhard Matthias Kresbach, Eveline Schürmann-Mader, Martin Andreas Bopp
  • Publication number: 20090224173
    Abstract: The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.
    Type: Application
    Filed: December 31, 2008
    Publication date: September 10, 2009
    Inventors: Gert Ludwig Duveneck, Martin Andreas Bopp, Michael Pawlak, Markus Ehrat, Gerd Marowsky
  • Publication number: 20090163374
    Abstract: The present invention relates to a process for detecting one or more analytes in one or more samples of biological origin having complex composition. The present invention also relates to a microarray for quantitative determination of one or more analytes in samples of biological origin having complex composition which are immobilized in measurement ranges of microarray, and also to a quantitative detection method based thereon.
    Type: Application
    Filed: October 29, 2005
    Publication date: June 25, 2009
    Inventors: Michael Pawlak, Eginhard Schick, Miro Venturi, Markus Ehrat
  • Patent number: 7517546
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 14, 2009
    Assignee: Bayer Technology Services GmbH
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schürmann-Mader, Markus Ehrat, Samuele Tosatti
  • Publication number: 20090061506
    Abstract: The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2??(IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2??(IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2- groups.
    Type: Application
    Filed: September 8, 2008
    Publication date: March 5, 2009
    Inventors: Rolf Hofer, Michael Pawlak, Marcus Textor, Eveline Schurmann-Mader, Markus Ehrat, Samuele Tosatti