Abstract: The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.

Abstract: A microwaveable packaged good article is described. The microwaveable packaged good article includes a container and an overcap. The container includes a base and a continuous wall extending from the base terminating in a chime. The overcap includes a panel, a neck extending from the panel terminating in a drip bead, and a skirt radially spaced from the drip bead to define a channel between the skirt and the drip bead. In this regard, the chime is received within the channel upon assembly of the overcap to the container.

Abstract: The invention is a hydrogen passivation shut down system for a fuel cell power plant (10). An anode flow path (24) is in fluid communication with an anode catalyst (14) for directing hydrogen fuel to flow adjacent to the anode catalyst (14), and a cathode flow path (38) is in fluid communication with a cathode catalyst (16) for directing an oxidant to flow adjacent to the cathode catalyst (16) of a fuel cell (12). Hydrogen fuel is permitted to transfer between the anode flow path (24) and the cathode flow path (38). A hydrogen reservoir (66) is secured in fluid communication with the anode flow path (24) for receiving and storing hydrogen during fuel cell (12) operation, and for releasing the hydrogen into fuel cell (12) whenever the fuel cell (12) is shut down.

Abstract: The invention is a hydrogen passivation shut down system for a fuel cell power plant (10). An anode flow path (24) is in fluid communication with an anode catalyst (14) for directing hydrogen fuel to flow adjacent to the anode catalyst (14), and a cathode flow path (38) is in fluid communication with a cathode catalyst (16) for directing an oxidant to flow adjacent to the cathode catalyst (16) of a fuel cell (12). Hydrogen fuel is permitted to transfer between the anode flow path (24) and the cathode flow path (38). A hydrogen reservoir (66) is secured in fluid communication with the anode flow path (24) for receiving and storing hydrogen during fuel cell (12) operation, and for releasing the hydrogen into fuel cell (12) whenever the fuel cell (12) is shut down.

Abstract: A buoyant pool chair supports a swimmer in an upright, semi-reclining or sitting position while the chair is floating in a swimming pool. Interconnected rigid frame members collectively form an open chair frame for supporting buoyant cushions. The buoyant cushions include layers of flexible cushion material secured together in overlapping relation, with the frame members being sandwiched between the overlapping layers. A layer of adhesive material bonds the overlapping cushion layers together and forms a water-tight seal around the frame members. A flexible layer of a water-resistant coating material is bonded to external surface portions of the buoyant cushions to provide a further protective layer and water-tight seal.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises solid-state elements containing active laser ion distributed within the volume. A cooling fluid flows about the solid-state elements and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Methods of fabricating large size, high performance multilayer diffraction gratings having a thick substrate that take advantage of reactive ion etching during the fabrication process are provided herein. In one implementation, a method of making a multilayer diffraction grating comprises the steps of: providing a substrate having a thickness of at least 2.0 cm; applying a dielectric structure having a plurality of layers on the semiconductor substrate; depositing a photoresist; exposing the photoresist to a grating pattern; developing the photoresist to produce the grating pattern in the photoresist; and reactive ion etching to transfer the grating pattern to the dielectric structure. In preferred form, the substrate material of the grating is selected to have low electrical resistivity and high thermal conductivity.

Abstract: The present invention is directed to a tool holder convertible between storage and display configurations and a method of manufacture therefore. In one embodiment, the tool holder includes a flexible wrapper including first and second parallel major and minor edges and a fold line located between the first and second major edges. The tool holder also includes a first fastener including first and second portions located proximate the first and second minor edges, respectfully, that is alignable in opposition to allow a coupling of the first and second minor edges.

Abstract: Fuel cell power plants (19, 47, 60, 86, 102, 112, 121) include recycle fuel from a fuel exit (29) of the last fuel flow field (23, 52, 64, 89) of a series of flow fields (20-23; 49-52; 61-64; 87-89) labeled M?N through M, applied either to the Mth flow fields or both the Mth and the (M?1)th flow fields. The fuel recycle impeller is a blower (30), a turbocompressor (30a) driven by an air exhaust, an ejector (30b) or an electrochemical hydrogen pump (30c). Fuel from a source (77) may be applied both to the first fuel flow field (87) and an additional fuel flow field (88, 74, 75, 89) of a series of flow fields to reduce pressure drop and flow rate requirements in the first of the series of flow fields and assure more fuel in the additional fuel flow field. Flow to the additional fuel flow field may be controlled by voltage (126) in such field or fuel content (128) of its exhaust. Transient fuel volume is provided by a tank (125).

Abstract: A method for operating a fuel cell power plant. The fuel cell can include a reactant passage (22) with an upstream portion and a downstream portion for providing reactant to an electrode (16, 18), at least one liquid passage (24), and a plate (20) made from a porous material that is liquid permeable and conductive. The porous material separates the reactant passage and the liquid passage. A pressure profile is controlled to provide a positive pressure difference in the upstream portion and a negative pressure difference in the downstream portion. A positive pressure difference is one where the liquid pressure is higher than that of the reactant. A negative pressure difference is one where the liquid pressure is less than that of the reactant. The pressure profile can be used to provide enhanced humidification of the reactant in the upstream portion and effective liquid water removal in the downstream portion to maximize both the performance and the life of the fuel cell.

Abstract: A freeze tolerant fuel cell power plant (10) includes at least one fuel cell (12), a coolant loop (18) including a freeze tolerant accumulator (22) for storing and separating a water immiscible fluid and water coolant, a direct contact heat exchanger (56) for mixing the water immiscible fluid and the water coolant within a mixing region (72) of the heat exchanger (56), a coolant pump (21) for circulating the coolant through the coolant loop (18), a radiator loop (84) for circulating the water immiscible fluid through the heat exchanger (56), and a radiator (86) for removing heat from the coolant. The plant (10) utilizes the water immiscible fluid during steady-state operation to cool the fuel cell and during shut down of the plant to displace water from the fuel cell (12) to the freeze tolerant accumulator (22).

Abstract: A power plant (10) includes at least one fuel cell (12), a coolant loop (18) including a freeze tolerant accumulator (22) for storing and separating a water immiscible fluid and water coolant, a direct contact heat exchanger (56) for mixing the water immiscible fluid and the water coolant within a mixing region (72) of the heat exchanger (56), a coolant pump (21) for circulating the coolant through the coolant loop (18), a radiator loop (84) for circulating the water immiscible fluid through the heat exchanger (56), a radiator (86) for removing heat from the coolant, and a direct contact heat exchanger by-pass system (200). The plant (10) utilizes the water immiscible fluid during steady-state operation to cool the fuel cell and during shut down of the plant to displace water from the fuel cell (12) to the freeze tolerant accumulator (22).

Abstract: A performance enhancing break-in method for a proton exchange membrane (“PEM”) fuel cell (12) includes cycling potentials of an anode electrode (14) and a cathode electrode (16) from a first potential to a second potential and back to the first potential, and repeating the cycling for each electrode (14, 16) for at least two electrode cycles. The potential cycling may be achieved in a first embodiment by applying a direct current from a programmable direct current power source (80) to the electrodes. Alternatively the potential cycling may be achieved by varying reactants to which the anode and cathode electrodes (14, 16) are exposed.

Abstract: The invention is a hydrogen passivation shut down system for a fuel cell power plant (10). An anode flow path (24) is in fluid communication with an anode catalyst (14) for directing hydrogen fuel to flow adjacent to the anode catalyst (14), and a cathode flow path (38) is in fluid communication with a cathode catalyst (16) for directing an oxidant to flow adjacent to the cathode catalyst (16) of a fuel cell (12). Hydrogen fuel is permitted to transfer between the anode flow path (24) and the cathode flow path (38). A hydrogen reservoir (66) is secured in fluid communication with the anode flow path (24) for receiving and storing hydrogen during fuel cell (12) operation, and for releasing the hydrogen into fuel cell (12) whenever the fuel cell (12) is shut down.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.