Abstract: The present invention provides methods of alleviating hypoxemia in a subject through oral administration of a methylthioninium compound.

Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: A tile of an FPGA includes a multiple mode arithmetic circuit. The multiple mode arithmetic circuit is configured by control signals to operate in an integer mode, a floating-point mode, or both. In some example embodiments, multiple integer modes (e.g., unsigned, two's complement, and sign-magnitude) are selectable, multiple floating-point modes (e.g., 16-bit mantissa and 8-bit sign, 8-bit mantissa and 6-bit sign, and 6-bit mantissa and 6-bit sign) are supported, or any suitable combination thereof. The tile may also fuse a memory circuit with the arithmetic circuits. Connections directly between multiple instances of the tile are also available, allowing multiple tiles to be treated as larger memories or arithmetic circuits. By using these connections, referred to as cascade inputs and outputs, the input and output bandwidth of the arithmetic circuit is further increased.

Abstract: A surgical boot apparatus for use in surgery involving hip distraction includes a boot shell having a sole portion configured for placement adjacent a sole of a foot of a patient and a calf portion configured for placement adjacent a calf of the patient. The boot shell has a heel-receiving opening located between the sole portion and the calf portion and configured for receipt of a heel of the patient. A resilient pad is provided having a main portion configured for engaging an Achilles area of the patient. The main portion includes an end region that extends into the heel-receiving opening. The end region has an end edge that includes a notch configured for receipt of a calcaneus of the patient.

Abstract: In response to an indication of a transition in a live workout, a synchronization identifier as metadata is embedded in a portion of a video stream of the live workout. The portion of the video stream of the live workout is transmitted to a remote client exercise machine. A hardware state of the remote client exercise machine is updated based at least in part on the synchronization identifier, at least in part to synchronize the remote client exercise machine with the live workout. In response to an exercise machine joining a video stream of a live workout, a timeline comprising a set of events that are to occur over the course of the live workout is received. A portion of the video stream of the live workout is received, wherein the portion of the video stream has embedded a synchronization identifier. The portion of the video stream is rendered.

Abstract: A dispenser capable of dispensing a fluid via a vertically-oriented piezo device comprises a reservoir in the form of a replaceable cartridge containing a fluid to be dispensed, a planar piezo element having front and rear surfaces and which in use is oriented with its plane vertical and which is drivable to vibrate and thereby dispense fluid from the front surface, and a pump to draw a predetermined amount, or dose, of fluid from the reservoir and to drive the dose of fluid at a predetermined above-atmospheric pressure to the rear surface of the piezo element for dispensing.

Abstract: A showerhead utilized within a process chamber includes a first inlet for receiving a first gas from a first source at a center region of an inner plenum defined therein. A plurality of second inlets is defined along a peripheral region of the showerhead for receiving a second gas from a second source. A plurality of conduits couples the edge plenum to an outer edge of the inner plenum so as to supply the second gas to the inner plenum. The first gas creates an inner flow that flows radially outward from the center region to an outer edge of the inner plenum and the second gas supplied by the edge plenum creates a perimeter flow that flows inward from the outer edge of the inner plenum toward the center region. A stagnation point defining an adjustable radius is formed at an interface of the first gas and the second gas.

Abstract: A purge baffle for a substrate support includes an annular ring configured to surround an outer perimeter around the substrate support in a volume below the substrate support and a first portion. The first portion includes a plenum defined below the first portion and outside of the annular ring in the volume below the substrate support and a plurality of openings that provide respective flow paths from a region above the first portion into the plenum. At least a first opening of the plurality of openings has a first conductance and at least a second opening of the plurality of openings has a second conductance that is different than the first conductance.

Abstract: A showerhead utilized within a process chamber includes a first inlet for receiving a first gas from a first source at a center region of an inner plenum defined therein. A plurality of second inlets is defined along a peripheral region of the showerhead for receiving a second gas from a second source. A plurality of conduits couples the edge plenum to an outer edge of the inner plenum so as to supply the second gas to the inner plenum. The first gas creates an inner flow that flows radially outward from the center region to an outer edge of the inner plenum and the second gas supplied by the edge plenum creates a perimeter flow that flows inward from the outer edge of the inner plenum toward the center region. A stagnation point defining an adjustable radius is formed at an interface of the first gas and the second gas.

Abstract: Some embodiments include a system comprising an extended reality (XR) display device configured to display an XR interface to a user; at least one hardware processor communicatively coupled to the XR display device and configured to perform: receiving a model of a room; receiving a plurality of furniture models corresponding to a plurality of pieces of furniture; providing the XR interface using the model of the room and the plurality of furniture models at least in part by: displaying, via the XR display device, a furniture display comprising at least some of the plurality of furniture models and a search field to permit entry of text; detecting entry of a text string into the search field; identifying, using the text string, at least one furniture model from the plurality of furniture models; and displaying, via the XR display device, the at least one furniture model in the furniture display.

Abstract: A program is presented to a user including a stream of content including a first auditory content and a first visual content related to the workout. A context state of the user participating in the workout is determined based on information from a sensor. A responsive content is selectively added based on the context state of the user to the stream of content in a manner that avoids conflict with the stream of content.

Abstract: A method for evacuating a volume below a substrate in a substrate processing system includes arranging the substrate on a lift mechanism of a substrate support to define the volume below the substrate between the substrate and an upper surface of the substrate support. An evacuation step is initiated to evacuate the volume below the substrate. The evacuation step includes pumping down the volume below the substrate at least one of through and around the lift mechanism. The lift mechanism is lowered during the evacuation step to position the substrate on the upper surface of the substrate support and the evacuation step is terminated.

Abstract: A tiered bowl system adapted for use as a dipping bowl, such as with salsa, for example. The bowl may have a forward portion with a rim at a first, lower, level and a rear portion with a rim of a second, higher, level. A lip may be attached to the rear portion which partially protrudes over the bowl. The tiered bowl system allows a user to dip into the bowl, and then to partially remove some of the material acquired from the dipping using the lip. The lip may be easily removable and replaceable to assist with cleaning and stacking of the bowl system.

Abstract: A patient positioner for supporting a patient in a prone position includes a base plate, an adjustable platform movable relative to the base plate, a support assembly supported on the adjustable platform, a lateral constraint assembly positioned on the adjustable platform, and a position lock operable to selectively lock the adjustable platform relative to the base plate. The patient positioner is adjustable to adjust the position of the patient and to adjust the orientation of the patient's spine in the coronal and sagittal planes.

Abstract: A program is presented to a user including a stream of content including a first auditory content and a first visual content related to the workout. A context state of the user participating in the workout is determined based on information from a sensor. A responsive content is selectively added based on the context state of the user to the stream of content in a manner that avoids conflict with the stream of content.

Abstract: A system to process a semiconductor substrate includes a substrate support assembly configured to support the semiconductor substrate. The substrate support assembly includes M resistive heaters respectively arranged in M zones in a layer of the substrate support assembly, where M is an integer greater than 1. The layer is adjacent to the semiconductor substrate. The substrate support assembly includes N temperature sensors arranged at N locations in the layer, where N is an integer greater than 1 and less than or equal to M. The system further includes a controller configured to control one or more of the M resistive heaters based on a temperature sensed by one of the N temperature sensors and average temperatures of one or more of the M zones.

Abstract: A substrate processing system includes a substrate support and a controller. The substrate support includes a lift pad, a plurality of zones, and a plurality of resistive heaters arranged throughout the plurality of zones. The plurality of resistive heaters includes separately-controllable resistive heaters arranged in respective ones of the plurality of zones. The controller is configured to determine a rotational position of a substrate arranged on the lift pad, selectively rotate the lift pad to adjust the substrate to the rotational position, and control the plurality of resistive heaters to selectively adjust temperatures within the plurality of zones based on the rotational position.

Abstract: A low-dose imaging method includes receiving a sparse image set of a portion of a patient's anatomy; up-sampling the sparse image set, in the sinogram domain and using a first neural network, to yield an up-sampled sinogram; generating, from the up-sampled sinogram, an initial reconstruction; and removing, from the initial reconstruction and using a second neural network, one or more artifacts in the initial reconstruction to yield a final output volume.

Abstract: Methods and apparatuses are provided herein for independently adjusting flowpath conductance. One multi-station processing apparatus may include a processing chamber, a plurality of process stations in the processing chamber that each include a showerhead having a gas inlet, and a gas delivery system including a junction point and a plurality of flowpaths, in which each flowpath includes a flow element, includes a temperature control unit that is thermally connected with the flow element and that is controllable to change the temperature of that flow element, and fluidically connects one corresponding gas inlet of a process station to the junction point such that each process station of the plurality of process stations is fluidically connected to the junction point by a different flowpath.