Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: The present invention relates to the field of automotive heat exchangers, and, in particular, to ribbed heat exchanger tanks. This invention uses ribs that are oriented perpendicular to the local wall bending axes, and, therefore, not necessarily perpendicular to or parallel with the plane of the header to improve resistance to thereby reduce wall deflection and reduce stress concentration in or near the ribs.

Abstract: A compact brake system for a wheeled vehicle fits substantially within the profile of a tire and rim to reduce wheel box width to increase cargo space between wheel boxes. In one embodiment, a caliper bracket is mounted on a spindle lever connected to a wheel spindle, eliminating the need for a standard brake flange extending from the spindle and thereby reducing the width of the brake system. The spindle lever is mounted on a torque bar rotatably mounted on an axle to allow vertical movement of the spindle to be reacted in a dampening mechanism. A brake caliper is mounted on the caliper bracket for brakingly engaging a brake rotor. The brake caliper, caliper bracket, spindle lever and spindle are substantially or entirely disposed within the tire profile. Alternately, the brake caliper may be mounted on a drop center spindle or used with a spindle mounted on an axle.

Abstract: An integrated kitchen unit for a mobile vehicle. The integrated kitchen unit intended to make preparation, eating, and cleaning easier and more intuitive than the existing solution. The integrated kitchen unit provides multiple storage areas based on the needs required for cooking, including storage for utensils, and even storage for a range of third party appliances. The microwave becomes an integrated part of the design, opening up additional space and allowing for optimized ergonomics of preparation surfaces. Extendable tables can be pulled out for additional surfaces or for other needs such as desk area. Standard 110V AC outlets included in the design allow drivers to plug in any third party appliance, possible providing inverters be installed in the berth. A disposal container is located on the side of the integrated kitchen unit, allowing for easy access while preparing at the workstation, and even while driving.

Abstract: A process of purifying metal-containing compounds employing continuous extraction is provided. The metal-containing compounds are provided in high purity and are suitable for use in depositing metal films, particularly thin metal films used in electronic devices.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: A method for precisely aligning a first optical component to a second optical component that is coupled to a substrate. At least one of a number of coupling elements is modified to attach the first optical component to the substrate. An optical coupling quality of the first optical component to the second optical component is determined. At least one of the modified coupling elements that couples the first optical component to the substrate is micro-manipulated to precisely align the first optical component with the second optical component and improve the optical coupling quality.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed herein is a nonwoven acoustic insulating material which also provides repellency to water and low surface tension fluids. Also disclosed is a method for attenuating transmitted sound and repelling fluids which includes providing a nonwoven acoustic insulating material, the nonwoven acoustic insulating material including at least one nonwoven web having a low surface tension fluids repellency treatment, and interposing the treated nonwoven acoustic insulating material between a sound generation area and a sound receiving area.

Abstract: A compact brake system for a wheeled vehicle fits substantially within the profile of a tire and rim to reduce wheel box width to increase cargo space between wheel boxes. In one embodiment, a caliper bracket is mounted on a spindle lever connected to a wheel spindle, eliminating the need for a standard brake flange extending from the spindle and thereby reducing the width of the brake system. The spindle lever is mounted on a torque bar rotatably mounted on an axle to allow vertical movement of the spindle to be reacted in a dampening mechanism. A brake caliper is mounted on the caliper bracket for brakingly engaging a brake rotor. The brake caliper, caliper bracket, spindle lever and spindle are substantially or entirely disposed within the tire profile. Alternately, the brake caliper may be mounted on a drop center spindle or used with a spindle mounted on an axle.

Abstract: A coaxial connector including an outer conductor, a glass to metal seal (GMS) assembly, and a center conductor, is disclosed. The outer conductor has a tubular shape and defines longitudinal axis. Here, the center conductor and the GMS assembly are coupled before they are placed within the outer conductor. When the GMS assembly is coaxially placed within the outer conductor, the GMS assembly and the outer conductor define a variable gap enclosure. Fusing agent such as solder is placed within the variable gap enclosure. A bead is inserted into the outer conductor surrounding the center conductor and engaging the center conductor at a circumferential slot. The slide-on dielectric bead provides support for the center conductor and maintains the center conductor's position within the outer conductor and its characteristic impedance throughout.

Abstract: A system for employers and other organizations desiring the results of fingerprint-based criminal history background checks to validate that the intended applicants' fingerprints were in fact used for the checks. This system includes: 1. A compatible method for capturing individual applicants' fingerprints for the purpose of conducting fingerprint-based criminal history background checks at collection points and means for transmitting the applicants' fingerprints and biographical data to an Automated Fingerprint Image System (AFIS); 2. A compatible device at the employer's location that captures an electronic image of one or more of the applicant's fingerprints and means for transmitting these fingerprints and biographical data to an Automated Fingerprint Image System (AFIS). These prints are captured solely for the purpose of validating that the applicants' fingerprints were captured at the collection points and were used for the criminal history background checks; and 3.

Abstract: Disclosed herein are extruded articles such as, for example, fibers and films, containing thermoplastic polymeric compositions having a copolymeric major component and a melt processable additive treatment, wherein the melt processable additives have enhanced segregation to or expression at the surface of the article, thereby improving the effect of the desired characteristic of the additive treatment. Also disclosed are multicomponent extruded thermoplastic articles having two or more distinct components arranged in a specific geometric arrangement, wherein the thermoplastic polymeric composition of at least one geometric component includes a copolymeric major component and a melt processable additive treatment. Also disclosed are web materials including the extruded articles.

Abstract: A solder preform for attaching an optical fiber having a diameter to a fiber attach pad, the solder preform comprising a body including solder at least on a bottom surface thereof, the body having a groove extending along a first face from a first end to a second, the groove being larger in width than the diameter of the optical fiber to allow unimpeded alignment of the optical fiber. The solder preform above, wherein the body is formed substantially as a geometric shape, for example, a substantially rectangular box, a substantially cubical box, substantially a cylinder, substantially a semi-cylinder, substantially a sphere, substantially a semi-sphere, and substantially a cone or any geometric shape having a flat surface and a groove found therein.

Abstract: Access privileges for a user are provided in a performance evaluation system by storing an organizational structure for an enterprise, a view and a class of services for the user. The organizational structure includes a plurality of levels and a plurality of members assigned to the levels. The view specifies the levels and the members of the organizational structure to which the user is allowed access. The class of services specify services of the performance evaluation system that the user is allowed to perform. The user has access privileges to perform services within the class of services for levels and members within the view.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.