Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw-) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

Abstract: The present invention relates to heat exchangers and heat exchanger assemblies, and, in particular, leak tight heat exchanger assemblies with coined or extruded corners. The present invention further provides for heat exchanger assemblies that improves leak tight features while maintaining or providing increased heat exchanger assembly structural integrity and durability. The present invention also provides for a method for making leak tight heat exchangers using various bonding processes.

Abstract: The present invention relates to the field of automotive heat exchangers, and, in particular, to heat exchanger tanks with headers. This invention eliminates the need for use of an inner flange on the header using a collar that also acts as a rib, thereby providing a compact foot plus header tank arrangement with lower stress on the gasket mating surface of the header and tank. The present invention also provides a method for providing improved headering means for automotive heat exchangers with plastic tanks and headers.

Abstract: The present invention relates to the field of automotive heat exchangers, and, in particular, to ribbed heat exchanger tanks. This invention uses ribs that are oriented perpendicular to the local wall bending axes, and, therefore, not necessarily perpendicular to or parallel with the plane of the header to improve resistance to thereby reduce wall deflection and reduce stress concentration in or near the ribs.

Abstract: The present invention provides a method of treating a nonwoven fabric to improve alcohol repellency that includes contacting a nonwoven fabric with an aqueous treatment solution that includes a non-ionic fluoropolymer and essentially no antistatic agent or less than 0.05 weight percent by weight of an antistatic agent. The present invention also provides a nonwoven fabric with improved alcohol repellency.

Abstract: The present invention provides a method of treating a substrate to improve the alcohol repellency of the substrate while minimizing the effect on the hydrostatic head value of the substrate that includes contacting a substrate with a treatment solution that includes an ionic fluoropolymer, a monovalent salt, and essentially no antistatic agent or less than 0.05 weight percent by weight of an antistatic agent.

Abstract: A fiber-coupled optical component package comprises a high thermal conductivity base, a housing including a ceramic substrate, an optical component mount aperture formed on the substrate and a substantially planar fiber mount region on the substrate adjacent to the optical component mount aperture. An optical component may be secured within an area defined by the optical component mount aperture and an optical fiber may be secured to the substantially planar fiber mount region to optically couple the fiber and the optical component. A package lid may be placed over one or more of the housing, the optical component, and a portion of the fiber.

Abstract: A solder preform for attaching an optical fiber having a diameter to a fiber attach pad, the solder preform comprising a body including solder at least on a bottom surface thereof, the body having a groove extending along a first face from a first end to a second, the groove being larger in width than the diameter of the optical fiber to allow unimpeded alignment of the optical fiber. The solder preform above, wherein the body is formed substantially as a geometric shape, for example, a substantially rectangular box, a substantially cubical box, substantially a cylinder, substantially a semi-cylinder, substantially a sphere, substantially a semi-sphere, and substantially a cone or any geometric shape having a flat surface and a groove found therein.

Abstract: A process control method that automatically and comprehensively manages the creation, storage and use of electronic records during the operation of a controlled process and for governing and documenting the users that operate the computer systems that are involved in the creation, storage and use of the electronic records. The method controls a process, such as a chemical process, by receiving measurement information relating to the process, applying rules to the received measurement information to determine a desired response, and sending control information to at least one device associated with the process, so as to modify the process. The method maintains the rules, measurements and control activity in transaction logs or audit trails related thereto in a secure database.

Abstract: A method of preparing Group VA organometal compounds in high yield and high purity by the reaction of a Grignard reagent with a Group VA metal halide in certain ethereal solvents is provided. A method of preparing Group VA organometal hydrides is also provided.

Abstract: A fiber-coupled optical component and housing comprising a substrate having a substantially planar fiber mount region and an optical component mount region adjacent to the fiber mount region. The optical component and housing may include a metallic mount pad formed over the fiber mount region and configured to bond to a metal solder preform, and may further include a metallized optical fiber coupled to the metallic mount pad by the metal solder preform. Alternately, the optical component and housing may include a fiber mount pad formed over the fiber mount region and configured to bond to a glass solder preform, and may further include a bare optical fiber coupled to the fiber mount pad by the glass solder preform. An optical component may be placed or formed within the area defined by the optical component mount region to desirably optically couple the optical component and the optical fiber.

Abstract: A fiber-coupled optical component package comprises a high thermal conductivity base, a housing including a ceramic substrate, an optical component mount aperture formed on the substrate and a substantially planar fiber mount region on the substrate adjacent to the optical component mount aperture. An optical component may be secured within an area defined by the optical component mount aperture and an optical fiber may be secured to the substantially planar fiber mount region to optically couple the fiber and the optical component. A package lid may be placed over one or more of the housing, the optical component, and a portion of the fiber.

Abstract: An animal resistant insert for a trash container is disclosed. The insert comprises a platform portion bounded by an edge and a flange portion extending from the edge of the platform portion at an angle. The flange portion terminates at a terminal circumference, the terminal circumference being approximately equal to the inner circumference of the trash container. The insert further comprises at least one handle extending from the platform portion. The insert may also comprise a rim of resilient material attached to the terminal circumference of the flange portion and at least one ventilation hole disposed on the platform portion.

Abstract: Disclosed is a computer-implemented method for estimating at least one requirement for migrating a computer-based application from a source platform to a target platform. The method comprises receiving identifications of respective migration tasks; correlating base costs to respective ones of said migration tasks; receiving identifications of migration attributes that affect migration cost; correlating cost factors to respective ones of said migration tasks, each of said cost factors indicating an amount by which a migration attribute affects the base cost of a migration task; and estimating a cost for each migration task, by applying the cost factors for each migration task to the base cost of the migration task.

Abstract: A manifold for a heat exchanger comprising a tank, a plurality of tubes arranged to receive fluid therein, a plurality of fins for interspacing the tubes, the fins extending along the length of the tubes to thereby define a core section, wherein the header section is formed with multi-point brazing interfaces for securing said header and said core section during a brazing process. One embodiment provides at least one doubled wall area in close proximity to the tube slot areas to form a structure of increased strength, permitting the material to be reduced in relative thickness. The manifold may be formed from flat sheet stock by extended side walls of the header portion joined by a separate cap to close a top portion of the manifold assembly for the purpose of collecting fluid to and from the tubes and said at least one inlet and outlet.

Abstract: A method and apparatus for laser cutting a target material is disclosed. The method includes the steps of generating laser pulses from a laser system and applying the laser pulses to the target material so that the laser pulses cut through the material. The laser pulses have an approximately ellipse shaped spot, have a temporal pulse width shorter than about 100 nanoseconds, and have an energy density from about 2 to about 20 times the ablation threshold energy of the target material. The laser pulses are applied to the material such that the major axis of the ellipse shaped spot moves parallel to the cutting direction. The spot has a leading edge and a trailing edge on the major axis, and the energy density of each laser pulse increases from zero to a maximum along the leading edge and decreases back to zero along the trailing edge.

Abstract: A manifold for a heat exchanger comprising a tank, a plurality of tubes arranged to receive fluid therein, a plurality of fins for interspacing the tubes, the fins extending along the length of the tubes to thereby define a core section, wherein the header section is formed with multi-point brazing interfaces for securing said header and said core section during a brazing process. One embodiment provides at least one doubled wall area in close proximity to the tube slot areas to form a structure of increased strength, permitting the material to be reduced in relative thickness. The manifold may be formed from flat sheet stock by extended side walls of the header portion joined by a separate cap to close a top portion of the manifold assembly for the purpose of collecting fluid to and from the tubes and said at least one inlet and outlet.

Abstract: A power take off assembly for a heat exchanger for a vehicle. The assembly includes a rectangular frame having passages all the vertical sides to marry with core tubes from the heat exchanger, a face plate with a hole to position the power take off sleeve, a back plate with a similar hole, and a sleeve to allow the power take off shaft to pass though the assembly when installed in a heat exchanger for an automobile/truck. The assembly is pieced together and tabs located on the perimeter of the frame lock the front and back plates into place, the sleeve is inserted in the holes, and the entire assembly is brazed in a one shot process.

Abstract: Disclosed are various forms of an active, isolated &bgr;-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (&bgr;-APPwt and &bgr;-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate &bgr;-secretase. Inhibitors of &bgr;-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.