Abstract: Embodiments of the present invention may provide an electronic negotiation framework and data storage system to facilitate the electronic trading of corporate bonds, government bonds, and other semi-liquid financial assets. The electronic negotiation framework may allow two or more market participants to engage each other in an electronic negotiation using numeric responses. These responses may be captured, stored, and then converted into market-standard, conversant messages which are transmitted over a communication network. This electronic “conversation” preferably follows a structured rubric determining the “receive/respond” prompts which enable opposing parties to more efficiently reach mutually agreeable transaction terms. All of these receive/respond messages may be stored in the computer system's database for structured review and analysis.

Abstract: A break-open single-dose package includes a panel defining a frangible region, one or more sheets coupled to the panel and defining a pocket therebetween for storing a spreadable consumable, and an applicator. The frangible region is adapted to form an opening through which the spreadable consumable can exit in response to folding of the panel. The applicator includes a backing and a vessel extending from the backing. The vessel defines a channel for receiving any spreadable consumable that exits the pocket. The applicator is positioned adjacent to the frangible region for permitting a user to spread on a surface any spreadable consumable that exits the pocket using the applicator without requiring the user's hand(s) to contact the spreadable consumable. The backing is configured to move with the panel and separate from the vessel in response to folding of the panel. Other example packages and/or applicators are also disclosed.

Abstract: A medication injection pen comprises a dose set knob rotatable with respect to a housing to set a desired injection dose. The dose set knob comprises at least one internal thread. A leadscrew includes a thread element for advancing in a first direction via a corresponding thread engagement. A driver is rotationally fixed to the leadscrew and is rotatable in a first direction to rotate and advance the leadscrew in the first direction. The setback member is rotationally fixed to the driver. The dose stop member is rotationally coupled to the setback member and is axially movable relative to the dose set knob when the dose set knob is rotated relative to the setback member. Axial movement of the dose stop member limits the user from setting a dose that is greater than an injectable volume of medication remaining in a cartridge.

Abstract: A medication injection method where a dose set knob of a medication injection pen is rotated with respect to the housing of the medication injection pen during dose setting and dose correcting, a driver is selectively engages with the dose set knob, the driver being rotatably fixed with respect to the housing during dose setting and dose correcting, the driver is moved axially with the dose set knob during the dose setting and the dose correcting, and the driver is rotated with the dose set knob during an injection.

Abstract: A system for locating a leak site in an underground water pipeline comprises a leak detection element, means for introducing the leak detection element into the pipeline through an outlet of a hydrant, and means for detecting the location of the leak detection element from above the ground. The means for introducing the leak detection element into the pipeline includes capping means adapted for attachment to, and sealing of, the outlet of the hydrant. The capping means has at least one opening therethrough to allow passage of an elongate rod or hose through the capping means and into the outlet of the hydrant. The capping means is provided with a substantially waterproof membrane to provide a seal between the capping means and the outlet of the hydrant, and the at least one opening is provided with a substantially waterproof membrane to provide a seal between the rod or hose and the at least one opening. A method for locating a leak site in an underground water pipeline is also provided.

Abstract: Methods are provided for creating dynamic lists from selected areas of a power system of a utility company. The utility company has an energy management system with a control panel. The energy management system is used to access one or more source displays of a site. Rubber-banding or lassoing is used to create selected areas from at least a portion of the source displays. Lists are created dynamically. Operator defined information is displayed for each element type in a list of network elements from the selected areas that have been rubber-banded or lassoed.

Abstract: The present disclosure provides an electrophysiology system to facilitate visualizing a proximity of at least one catheter electrode to a 3D geometry of a biological tissue. The system includes a computing device including at least one processor in communication with a memory, wherein the processor is configured to determine the proximity between the at least one catheter electrode and the biological tissue using at least one measurement. The system further includes a display device configured to display the 3D geometry of the biological tissue and a visual effect illustrating the proximity between the at least one catheter electrode and the biological tissue.

Abstract: A medication injection pen, comprising a housing, a dose set knob that rotates with respect to the housing during dose setting and dose correcting, and a driver selectively engaged with the dose set knob, the driver rotatably fixed with respect to the housing during dose setting and dose correcting, wherein the driver moves axially with the dose set knob during dose setting and dose correcting, and the driver rotates with the dose set knob during an injection.

Abstract: A medication injection pen, including a housing, a dose set knob (DSK) comprising an internal key, and a dose stop member engaging the dose set knob. Rotation of the dose set knob to set a medication dose causes rotation of the dose stop member with respect to the dose set knob, and when the dose set knob is rotated to a last dose setting position, the dose stop member rotationally abuts the internal key thereby preventing further rotational movement of the dose set knob in a dose setting direction.

Abstract: Approaches are provided for creating a new control tab associated with the at least one main area display, rubber-banding or lassoing a first selected area from the at least one main area display; dragging the first selected area to the new control tab to create of a list of electronic network elements that are disposed within the first selected area, and obtaining vital information associated with the electronic network elements on the list and presenting the list and the vital information to an operator at a user interface.

Abstract: A self-sealing safety valve (10) for a container of pressurised fluid (12) comprises a substantially solid body (14) and attachment means (24) for connecting to a dispensing valve. The self-sealing safety valve includes a substantially central bore (16) extending through both the attachment means and the solid body, and the bore connects an inlet (20) to an outlet (18). The bore comprises at least three parts each of a different diameter: a first part (16a) immediately adjacent the outlet has a first diameter; a second part (16b) located immediately adjacent the first part has a second diameter that is wider diameter than the first diameter; and a third (16c) part located immediately adjacent the second part has a third diameter that is wider than the second diameter. The second part of the bore houses a first biasing means (30). The third part of the bore houses a sealing ball (28) and a second biasing means (38), and the sealing ball is located between the first and second biasing means.

Abstract: A sealing element (10) for use in a fluid-carrying pipeline (16) comprising a substantially central core (14) surrounded by a coating (12). The outer coating (12) is adapted to perform a partial extrusion through an opening (15) in a pipeline wall (16) to seal the opening (15). The density of the sealing element (10) is substantially the same as the density of the fluid (11) in the pipeline (16). The coating (12) comprises a two-part epoxy putty, and the core (14) is formed from a deformable material. A method of making the sealing element is also disclosed.

Abstract: A medication injection pen, including a housing, a dose set knob (DSK) comprising an internal thread and an internal key proximate to a distal end of the internal thread, and a dose stop member comprising an external thread engaging the internal thread of the dose set knob. Rotation of the dose set knob to set a medication dose causes lateral translation of the dose stop member with respect to the dose set knob, and when the dose set knob is rotated to a last dose setting position, the dose stop member rotationally abuts the internal key thereby preventing further rotational movement of the dose set knob in a dose setting direction.

Abstract: Described herein are methods and systems for secure communication of private audio data in a zero user interface computing environment. A server receives text generated from a first digital audio bitstream, the digital audio bitstream corresponding to speech captured by a zero user interface computing device from a user. The server analyzes the text to extract a set of keywords from the text. The server determines whether information responsive to the keywords comprises private data related to the user. If the information responsive to the set of keywords comprises private data: the server generates a text response to the set of keywords that includes the private data relating to the user, determines a personal audio playback device associated with the user, and transmits the generated text response to the personal audio playback device for playback as a second digital audio bitstream.

Abstract: A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

Abstract: Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods are provided. In one embodiment, a method of dispensing a substance to an intended user is provided. The method comprises receiving an input from a biometric sensor; determining, based on the received input, whether an intended user's unique biometric attribute is detected by the biometric sensor; receiving an input from an environmental sensor; determining, based on the received input, whether a mouthpiece is positioned within a user's mouth; receiving an input from a capacitive sensor array of the mouthpiece; determining, based on the received input, whether an intended user's unique dentition is positioned within a recess of the mouthpiece; and dispensing a substance from a reservoir to a mouth of the intended user in response to determining that the intended user's unique biometric attribute is detected by the biometric sensor.

Abstract: Methods are provided for assessing reliability of a power system of a utility company. At least one main overview display is obtained. Violation markers are displayed on the one main overview display. A monitored elements tab is updated with a list of monitored elements.

Abstract: A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

Abstract: Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods are provided. In one embodiment, a substance dispensing apparatus includes a housing sized and shaped for handheld use, the housing having at least one wall and a biometric sensor coupled to the at least one wall; a processor in communication with the biometric sensor, the processor configured to determine whether an intended user's unique biometric attribute is detected by the biometric sensor based on input received from the biometric sensor; and a pump in communication with the processor, the pump configured to dispense a substance from a reservoir to a mouth of the intended user in response to the processor determining that the intended user's unique biometric attribute is detected by the biometric sensor.

Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.