Patents by Inventor Michael R. King

Michael R. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220143109
    Abstract: The invention relates to compositions comprising microbial strains for use in inhibiting viruses, and methods therefor. More particularly, the invention relates to compositions of isolated Bacillus strains selected from the group consisting of isolated Bacillus strains 300, 86, 101, 235, 102, 177, A12, 54, 681, 721, strains having all of the identifying characteristics of these strains, and combinations thereof, and methods for use of these strains for virus inhibition.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 12, 2022
    Inventors: Michael R. KING, Sona SON, Nathan Robert AUGSPURGER, Joel Dean SPENCER, Kyle LEISTIKOW
  • Publication number: 20210360945
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: December 22, 2020
    Publication date: November 25, 2021
    Inventors: Michael R. King, Sona Son, Nathan Robert Augspurger, Joel Dean Spencer, Amy Lange, Michael D. Engelhardt
  • Publication number: 20210338738
    Abstract: The present disclosure describes engineering of cells to co-express TNF-Related Apoptosis-Inducing Ligand (TRAIL) and Decoy Receptor 1 (DcR1). The expression of DcR1 results in competition for TRAIL binding to Death Receptors 4 and 5, thereby protecting the engineered cells from TRAIL-induced apoptosis. Such cells will exhibit longer survival such as when used in cell-based therapies for cancer.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 4, 2021
    Applicant: Vanderbilt University
    Inventors: Michael R. KING, Nidhi JYOTSANA
  • Patent number: 11110134
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: September 7, 2021
    Assignees: Microbial Discovery Group, LLC, United Animal Health, Inc.
    Inventors: Michael R. King, Sona Son, Kyle Leistikow, Nathan Robert Augspurger
  • Publication number: 20210236563
    Abstract: The invention relates to direct-fed microbials for use in E. coli, Salmonella, and/or Campylobacter inhibition in animals. More particularly, the invention relates to isolated Bacillus strains A12, 54, 681, 101, 235, and 721, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention also relates to the use of isolated Bacillus strains 681,721, A12, 54, 86, 300, 101, 102, 235, and 177, and strains having all of the identifying characteristics of these strains, to prevent or reduce prolapse in an animal.
    Type: Application
    Filed: May 1, 2019
    Publication date: August 5, 2021
    Inventors: Michael R. KING, Sona SON, Kyle LEISTIKOW, Joel D. SPENCER
  • Patent number: 10905135
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: February 2, 2021
    Assignee: Microbial Discovery Group, LLC
    Inventors: Michael R. King, Sona Son, Nathan Robert Augspurger, Joel Dean Spencer, Amy Lange, Michael D. Engelhardt
  • Publication number: 20200369849
    Abstract: The invention relates to treatment of waste with one or more microorganisms for the purposes of, including but not limited to, degrading waste, bioremediation of waste, enhancing waste stabilization, reducing contaminants in waste, reducing odor in waste, reducing organics in waste, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: November 2, 2018
    Publication date: November 26, 2020
    Inventors: Michael R. KING, Sona SON, Claire HEILE
  • Publication number: 20200170257
    Abstract: The invention relates to treatment of a plant with one or more microorganisms for inhibiting a plant pathogen. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for a use comprising the above-mentioned use.
    Type: Application
    Filed: September 27, 2019
    Publication date: June 4, 2020
    Inventors: Michael R. KING, Sona SON, Amy LANGE, Megan DUERSTELER, Elizabeth GALBRAITH
  • Publication number: 20200138877
    Abstract: The invention relates to direct-fed microbials for use in improving reproductive performance in animals, decreasing death loss and/or off-feed events in animals, improving milk production and/or milk quality in dairy animals, and inhibiting a disease or disorder in dairy animals selected from the group consisting of milk fever, ketosis, retained placenta, metritis, pneumonia, and displaced abomasum. More particularly, the invention relates to isolated Bacillus strains 86, 300, 101, 235, 177, and 102, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: October 2, 2019
    Publication date: May 7, 2020
    Inventors: Michael R. KING, Sona SON, Elizabeth GALBRAITH, Samanta R. FENSTERSEIFER, Ricardo P. ARIAS
  • Publication number: 20200029592
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: October 3, 2019
    Publication date: January 30, 2020
    Inventors: Michael R. King, Sona Son, Nathan Robert Augspurger, Joel Dean Spencer, Amy Lange, Michael D. Engelhardt
  • Publication number: 20200016217
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.
    Type: Application
    Filed: June 27, 2019
    Publication date: January 16, 2020
    Inventors: Michael R. King, Sona SON, Kyle Leistikow, Nathan Robert Augspurger
  • Publication number: 20200015497
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: June 27, 2019
    Publication date: January 16, 2020
    Inventors: Michael R. King, Sona Son, Nathan Robert Augspurger, Joel Dean Spencer, Amy Lange, Michael D. Engelhardt
  • Publication number: 20200009225
    Abstract: Compositions and methods for inhibiting metastatic cancer cells. The compositions comprise nanoparticles which have incorporated therein leukocyte adhesion molecules and therapeutic molecules exposed on their surface. The nanoparticles may be provided attached to leukocytes. Introduction of these compositions in to the circulation of individuals results in inhibition and reduction of metastatic cancer cells.
    Type: Application
    Filed: August 23, 2019
    Publication date: January 9, 2020
    Inventors: Michael R. King, Michael J. Mitchell, Kuldeepsinh Rana, Elizabeth C. Wayne, Chris B. Schaffer, Siddarth Chandrasekaran
  • Patent number: 10391146
    Abstract: Compositions and methods for inhibiting metastatic cancer cells. The compositions comprise nanoparticles which have incorporated therein leukocyte adhesion molecules and therapeutic molecules exposed on their surface. The nanoparticles may be provided attached to leukocytes. Introduction of these compositions in to the circulation of individuals results in inhibition and reduction of metastatic cancer cells.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: August 27, 2019
    Assignee: Cornell University
    Inventors: Michael R. King, Michael J. Mitchell, Kuldeepsinh Rana, Elizabeth C. Wayne, Chris B. Schaffer, Siddarth Chandrasekaran
  • Patent number: 10357046
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: July 23, 2019
    Assignee: Microbial Discovery Group, LLC
    Inventors: Michael R. King, Sona Son, Nathan Robert Augspurger, Joel Dean Spencer, Amy Lange, Michael D. Engelhardt
  • Patent number: 10335440
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 2, 2019
    Assignees: Microbial Discovery Group, LLC, United Animal Health, Inc.
    Inventors: Michael R. King, Sona Son, Kyle Leistikow, Nathan Robert Augspurger
  • Publication number: 20180298428
    Abstract: This invention relates to a method of detecting a gene. The invention also relates to a method of determining the Amplification expression level of a gene. The invention also relates to compositions for use in these methods.
    Type: Application
    Filed: April 29, 2016
    Publication date: October 18, 2018
    Applicants: Microbial Discovery Group LLC, JBS United, Inc.
    Inventors: Michael R KING, Sona SON, Joel D SPENCER, Amy LANGE, Jessica EDWARD, Ardean VELDKAMP
  • Publication number: 20170246224
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 31, 2017
    Inventors: Michael R. KING, Sona SON, Kyle LEISTIKOW, Nathan Robert AUGSPURGER
  • Publication number: 20170166466
    Abstract: The invention relates to cold temperature-resistant microbials for use in waste water treatment. More particularly, the invention relates to isolated Bacillus strains ALG and DRT, and strains having all of the identifying characteristics of these strains, and combinations thereof, for a use comprising the above-mentioned use.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Michael R. KING, Sona SON
  • Publication number: 20170079308
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 23, 2017
    Applicant: MICROBIAL DISCOVERY GROUP, LLC
    Inventors: Michael R. KING, Sona SON, Nathan Robert AUGSPURGER, Joel Dean SPENCER, Amy LANGE, Michael D. ENGLEHARDT