Patents by Inventor Michael R. King

Michael R. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12162992
    Abstract: The invention relates to treatment of waste with one or more microorganisms for the purposes of, including but not limited to, degrading waste, bioremediation of waste, enhancing waste stabilization, reducing contaminants in waste, reducing odor in waste, reducing organics in waste, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for uses comprising the above-mentioned uses.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: December 10, 2024
    Assignee: MICROBIAL DISCOVERY GROUP, LLC
    Inventors: Michael R. King, Sona Son, Claire Heile
  • Patent number: 12157690
    Abstract: The invention relates to cold temperature-resistant microbials for use in waste water treatment. More particularly, the invention relates to isolated Bacillus strains ALG and DRT, and strains having all of the identifying characteristics of these strains, and combinations thereof, for a use comprising the above-mentioned use.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 3, 2024
    Assignee: MICROBIAL DISCOVERY GROUP LLC
    Inventors: Michael R. King, Sona Son
  • Publication number: 20240358770
    Abstract: The invention relates to direct-fed microbials for use in Enterococcus species inhibition in animals. More particularly, the invention relates to isolated Bacillus strains A12, 681, 101, 235, 177, 86, and 300, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention also relates to the use of isolated Bacillus strains A12, 681, 101, 235, 177, 86, and 300, and strains having all of the identifying characteristics of these strains, to prevent or reduce or control pododermatitis (footpad disease) in an animal.
    Type: Application
    Filed: July 28, 2022
    Publication date: October 31, 2024
    Inventors: Elizabeth GALBRAITH, Sona SON, Michael R. KING
  • Publication number: 20240343624
    Abstract: The invention relates to compositions comprising microbial strains and methods for use of the compositions in removing hydrocarbons from water and/or soil. More particularly, the invention relates to compositions of isolated Bacillus strains selected from the group consisting of isolated Bacillus strains Bacillus licheniformis MDG-1000 (NRRL No. B-67888), Bacillus pumilus MDG-1047 (NRRL No. B-67891), and Bacillus amyloliquefaciens MDG1607 (NRRL No. B-67666), or strains having all of the identifying characteristics of these strains, and combinations thereof, and methods for use of these strains for removing hydrocarbons from water and/or soil. The invention also relates to a method of removing oil in a cleaning application as described herein.
    Type: Application
    Filed: August 9, 2022
    Publication date: October 17, 2024
    Inventors: Michael R. KING, Sona SON, Megan DUERSTELER
  • Patent number: 12115198
    Abstract: The invention relates to direct-fed microbials for use in improving reproductive performance in animals, decreasing death loss and/or off-feed events in animals, improving milk production and/or milk quality in dairy animals, and inhibiting a disease or disorder in dairy animals selected from the group consisting of milk fever, ketosis, retained placenta, metritis, pneumonia, and displaced abomasum. More particularly, the invention relates to isolated Bacillus strains 86, 300, 101, 235, 177, and 102, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: October 15, 2024
    Assignees: ·MICROBIAL DISCOVERY GROUP, LLC, UNITED ANIMAL HEALTH, INC.
    Inventors: Michael R. King, Sona Son, Elizabeth Galbraith, Samanta R. Fensterseifer, Ricardo P. Arias
  • Publication number: 20240327792
    Abstract: Disclosed herein is an improved method for ex vivo activation of immune effector cells that involves applying an effective amount of fluid shear stress to the immune effector cells, and exposing the immune effector cells to one or more activating agents before, during, or after shear stress application. Also disclosed is a method for manufacturing a human immune effector cell therapeutic that involves obtaining a population of peripheral blood mononuclear cells (PBMCs) that comprises immune effector cells in a fluid medium; applying fluid shear stress to the immune effector cells, optionally exposing the immune IC effector cells to one or more activating agents before, during, or after shear stress application; and culturing the activated immune effector cells in a cell growth medium to expand the activated immune effector cells, thereby manufacturing the human immune effector cell therapeutic.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 3, 2024
    Inventors: Michael R. King, Jacob M. Hope, Jenna A. Dombroski, Nicole Suzanne Sarna
  • Publication number: 20240294993
    Abstract: This invention relates to a method of detecting a gene, a method of determining the expression level of a gene, and compositions for use in these methods.
    Type: Application
    Filed: February 12, 2024
    Publication date: September 5, 2024
    Inventors: Michael R. KING, Sona SON, Joel D. SPENCER, Amy LANGE, Jessica EDWARD, Ardean VELDKAMP
  • Patent number: 11998576
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals. More particularly, the invention relates to isolated Bacillus strains 101, 235, 77, 177, and 102 and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention can also be used for treatment of plants and in food processing.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: June 4, 2024
    Assignees: MICROBIAL DISCOVERY GROUP, LLC, UNITED ANIMAL HEALTH, INC.
    Inventors: Michael R. King, Sona Son, Kyle Leistikow, Nathan Robert Augspurger
  • Publication number: 20240139260
    Abstract: The invention relates to microbials for use in improving the health of a human and animals. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use, in particular for improving the gastrointestinal health of animals or humans.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 2, 2024
    Inventors: Michael R. King, Sona Son, Jessica Edward, Kyle Leistikow
  • Publication number: 20240139334
    Abstract: The present disclosure is directed to engineered nanoparticles/liposomes that inhibit enveloped viruses and methods for use thereof.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 2, 2024
    Applicant: Vanderbilt University
    Inventors: Michael R. KING, Zhenjiang ZHANG
  • Publication number: 20240130401
    Abstract: The invention relates to direct-fed microbials for use in improving the performance of an animal and improving the health of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus coagulans strains, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: October 5, 2023
    Publication date: April 25, 2024
    Inventors: Michael R. King, Sona Son
  • Patent number: 11944656
    Abstract: The invention relates to direct-fed microbials for use in E. coli, Salmonella, and/or Campylobacter inhibition in animals. More particularly, the invention relates to isolated Bacillus strains A12, 54, 681, 101, 235, and 721, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention also relates to the use of isolated Bacillus strains 681,721, A12, 54, 86, 300, 101, 102, 235, and 177, and strains having all of the identifying characteristics of these strains, to prevent or reduce prolapse in an animal.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: April 2, 2024
    Assignees: MICROBIAL DISCOVERY GROUP, LLC, UNITED ANIMAL HEALTH, INC.
    Inventors: Michael R. King, Sona Son, Kyle Leistikow, Joel D. Spencer
  • Publication number: 20240002626
    Abstract: The invention relates to treatment of waste with one or more microorganisms for the purposes of, including but not limited to, degrading waste, bioremediation of waste, enhancing waste stabilization, reducing contaminants in waste, reducing odor in waste, reducing organics in waste, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: April 13, 2023
    Publication date: January 4, 2024
    Inventors: Michael R. KING, Sona SON, Claire HEILE
  • Publication number: 20230346854
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals in combination with enrofloxacin. More particularly, the invention relates to isolated Bacillus strains 9, 57, 71, and 126, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use.
    Type: Application
    Filed: August 18, 2021
    Publication date: November 2, 2023
    Inventors: Michael R. KING, Sona SON, Kyle LEISTIKOW
  • Publication number: 20230321162
    Abstract: The invention relates to direct-fed microbials for use in E. coli inhibition in animals in combination with antibiotics selected from the group consisting of ceftiofur, oxytetracycline, tulathromycin, and lincomycin. More particularly, the invention relates to isolated Bacillus strains 2, 3, 4, 5, 9, 57, 71, and 126, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use.
    Type: Application
    Filed: August 18, 2021
    Publication date: October 12, 2023
    Inventors: Michael R. KING, Sona SON, Kyle LEISTIKOW
  • Publication number: 20230284631
    Abstract: The invention relates to treatment of a plant with one or more microorganisms for inhibiting a plant pathogen. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for a use comprising the above-mentioned use.
    Type: Application
    Filed: April 13, 2023
    Publication date: September 14, 2023
    Inventors: Michael R. KING, Sona SON, Amy LANGE, Megan DUERSTELER, Elizabeth GALBRAITH
  • Patent number: 11634554
    Abstract: The invention relates to treatment of waste with one or more microorganisms for the purposes of, including but not limited to, degrading waste, bioremediation of waste, enhancing waste stabilization, reducing contaminants in waste, reducing odor in waste, reducing organics in waste, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for uses comprising the above-mentioned uses.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: April 25, 2023
    Assignee: Microbial Discovery Group, LLC
    Inventors: Michael R. King, Sona Son, Claire Heile
  • Patent number: 11627741
    Abstract: The invention relates to treatment of a plant with one or more microorganisms for inhibiting a plant pathogen. More particularly, the invention relates to isolated Bacillus strains, and strains having all of the identifying characteristics of these strains, and combinations thereof, for a use comprising the above-mentioned use.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 18, 2023
    Assignee: Microbial Discovery Group, LLC
    Inventors: Michael R. King, Sona Son, Amy Lange, Megan Duersteler, Elizabeth Galbraith
  • Publication number: 20220295828
    Abstract: The invention relates to direct-fed microbials for use in E. coli and/or Clostridium inhibition in animals in combination with antibiotics. More particularly, the invention relates to isolated Bacillus strains 2, 3, 4, 5, 6, 7, 9, 57, 71, and 126, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 22, 2022
    Inventors: Michael R. KING, Sona SON, Kyle LEISTIKOW
  • Publication number: 20220289607
    Abstract: The invention relates to compositions comprising microbial strains and methods for use of the compositions in removing pollutants in waste, water, or soil, such as remediating dye and lignin, reducing contaminants, degrading paper (such as flushable or disposable or non-flushable wipes), reducing odor, reducing chemical oxygen demand (COD), and combinations thereof, in the water, the soil, or the waste or for use in administration to animals in the feed or drinking water of the animals. More particularly, the invention relates to compositions of isolated Bacillus strains selected from the group consisting of isolated Bacillus strains Bacillus licheniformis MDG-1000 (NRRL No. B-67888), Bacillus licheniformis MDG-1001 (NRRL No. B-67889), Bacillus subtilis/amyloliquefaciens MDG-8001 (NRRL No. B-67890), Bacillus pumilus MDG-1047 (NRRL No. B-67891), Bacillus amyloliquefaciens MDG1607 (NRRL No. B-67666), Bacillus subtilis MDGV18 (NRRL No. B-67665), Bacillus pumilus MDGV17 (NRRL No.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 15, 2022
    Inventors: Michael R. KING, Sona SON, Claire HEILE