Patents by Inventor Michael R. King

Michael R. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170079308
    Abstract: The present invention is directed to direct-fed microbials for use in improving the performance of an animal, improving the health of an animal, improving the environment of an animal, and combinations thereof. More particularly, the invention relates to isolated Bacillus strains 86 and 300, and strains having all of the identifying characteristics of these strains, for uses comprising the above-mentioned uses.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 23, 2017
    Applicant: MICROBIAL DISCOVERY GROUP, LLC
    Inventors: Michael R. KING, Sona SON, Nathan Robert AUGSPURGER, Joel Dean SPENCER, Amy LANGE, Michael D. ENGLEHARDT
  • Publication number: 20160184395
    Abstract: Compositions and methods for inhibiting metastatic cancer cells. The compositions comprise nanoparticles which have incorporated therein leukocyte adhesion molecules and therapeutic molecules exposed on their surface. The nanoparticles may be provided attached to leukocytes. Introduction of these compositions in to the circulation of individuals results in inhibition and reduction of metastatic cancer cells.
    Type: Application
    Filed: August 4, 2014
    Publication date: June 30, 2016
    Inventors: Michael R. King, Michael J. Mitchell, Kuldeepsinh Rana, Elizabeth C. Wayne, Chris B. Schaffer, Siddarth Chandrasekaran
  • Patent number: 8399205
    Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. The molecules can be directly coated on the surface or coated on nanoparticles that are adhered to the surface. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: March 19, 2013
    Assignee: The University of Rochester
    Inventors: Michael R. King, David G. Foster, Woojin Han, Bryce A. Allio
  • Publication number: 20120252116
    Abstract: The present invention relates to device and method for cell trafficking. In particular, the invention relates to a fluid flow device in which the flow surface has nanotubes immobilized thereon. The nanotubes have molecules on their outer surface, which support cell rolling. Also provided is a method for separation of a cell type from a mixture of different cell types or from a fluid based on the differential rolling property of the cell type on the flow surface.
    Type: Application
    Filed: October 8, 2010
    Publication date: October 4, 2012
    Applicant: Cornell University
    Inventors: Michael R. King, Andrew Hughes
  • Publication number: 20100167372
    Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. The molecules can be directly coated on the surface or coated on nanoparticles that are adhered to the surface. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
    Type: Application
    Filed: November 20, 2009
    Publication date: July 1, 2010
    Inventors: Michael R. King, David G. Foster, Woojin Han, Bryce A. Allio
  • Publication number: 20100151573
    Abstract: The present invention is directed to methods for delivery of payload molecules to selected cells. The method comprises payload carrying delivery vehicles tagged with selectin or selectin-ligands. The payload carrying delivery vehicles are immobilized on flow surfaces and payload is delivered to targeted cells during rolling. The invention is also directed to compositions and devices for carrying out the method.
    Type: Application
    Filed: November 17, 2009
    Publication date: June 17, 2010
    Inventors: Michael R. King, Zhong Huang
  • Publication number: 20090253204
    Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
    Type: Application
    Filed: October 17, 2008
    Publication date: October 8, 2009
    Applicant: University of Rochester
    Inventors: Michael R. King, Nichola Charles, Jane Liesveld, John P. Gentile, Nathan Clark, Nipa A. Mody
  • Publication number: 20090022768
    Abstract: The present invention relates to methods and apparatuses for neutralizing cancer cells. In particular, the invention relates to separating of cancer cell type from a mixture of different cell types based on the differential rolling property of cancer cell on a substrate coated with a first molecules that exhibits adhesive property with the particular cell type and neutralizing the cancer cell by a second molecule that is also coated on the substrate. This technology is adaptable for use in vivo, in vitro, or ex vivo tumor neutralization.
    Type: Application
    Filed: January 16, 2008
    Publication date: January 22, 2009
    Inventors: Michael R. King, Jane Liesveld, Kuldeepsinh Rana
  • Patent number: 7267752
    Abstract: Rapid, size-based, deposition of particles from liquid suspension is accomplished using a nonuniform electric field created by coplanar microelectrode strips patterned on an insulating substrate. The scheme uses the dielectrophoretic force both to distribute aqueous liquid containing particles and, simultaneously, to separate the particles. Size-based separation is found within nanoliter droplets formed along the structure after voltage removal. Bioparticles or macromolecules of similar size can also be separated based on subtle differences in dielectric property, by controlling the frequency of the AC current supplied to the electrodes.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: September 11, 2007
    Assignee: University of Rochester
    Inventors: Michael R. King, Oleg Lomakin, Thomas B. Jones, Rajib Ahmed
  • Patent number: 6497382
    Abstract: A cord holder having a body member with cord retaining regions on each end with the body member having a temporally securable closure member on each end to allow quick passage of a cord into the cord retaining regions with the securable closure members securable to each other to hold the cord on the body member and the body member having an integral flexible member for securing and end of a cord to be wound thereon as one begins to wind the cord around the cord holder.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: December 24, 2002
    Inventor: Michael R. King
  • Patent number: 6425543
    Abstract: A cord holder having a body member with cord retaining regions on each end with the body member having a temporally securable closure member on each end to allow quick passage of a cord into the cord retaining regions with the securable closure members securable to each other to hold the cord on the body member.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: July 30, 2002
    Inventor: Michael R. King
  • Publication number: 20020084373
    Abstract: A cord holder having a body member with cord retaining regions on each end with the body member having a temporally securable closure member on each end to allow quick passage of a cord into the cord retaining regions with the securable closure members securable to each other to hold the cord on the body member.
    Type: Application
    Filed: January 2, 2001
    Publication date: July 4, 2002
    Inventor: Michael R. King
  • Publication number: 20020084374
    Abstract: A cord holder having a body member with cord retaining regions on each end with the body member having a temporally securable closure member on each end to allow quick passage of a cord into the cord retaining regions with the securable closure members securable to each other to hold the cord on the body member and the body member having an integral flexible member for securing and end of a cord to be wound thereon as one begins to wind the cord around the cord holder.
    Type: Application
    Filed: November 1, 2001
    Publication date: July 4, 2002
    Inventor: Michael R. King
  • Patent number: 6150171
    Abstract: An isolated nucleic acid from the bacterium Thermotoga neapolitana, encoding a thermostable .alpha.-galactosidase is provided. The Thermotoga gene is cloned into a high expression vector to provide large quantities of a purified thermostable .alpha.-galactosidase. The thermostable enzyme is used in high-temperature processing of soy products to remove .alpha.-galactosides.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 21, 2000
    Assignees: Rutgers, The State University of New Jersey, The Board of Trustees of the University of Illinois
    Inventors: Dinesh Yernool, Douglas E. Eveleigh, Michael R. King, Bruce Chassy
  • Patent number: D436598
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 23, 2001
    Assignee: Wirsbo of Canada
    Inventors: Michael R. King, Harish K. Patel
  • Patent number: D471939
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: March 18, 2003
    Inventor: Michael R. King
  • Patent number: D472286
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: March 25, 2003
    Inventor: Michael R. King
  • Patent number: D435224
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: December 19, 2000
    Assignee: WIRSBO of Canada, Inc.
    Inventors: Michael R. King, Harish K. Patel