Patents by Inventor Michael R. Roberts

Michael R. Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11779680
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: October 10, 2023
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Publication number: 20210046215
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 18, 2021
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, JR.
  • Patent number: 10814034
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: October 27, 2020
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Publication number: 20180326119
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 15, 2018
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, JR.
  • Patent number: 10022472
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: July 17, 2018
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Publication number: 20160317708
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: June 24, 2016
    Publication date: November 3, 2016
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Patent number: 9398948
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: July 26, 2016
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Publication number: 20140257516
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Patent number: 8747467
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: June 10, 2014
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Publication number: 20130149356
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
    Type: Application
    Filed: February 7, 2013
    Publication date: June 13, 2013
    Applicant: RTI BIOLOGICS, INC.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Patent number: 8394141
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 12, 2013
    Assignee: RTI Biologics, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell
  • Publication number: 20110091516
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: September 9, 2010
    Publication date: April 21, 2011
    Applicant: Regeneration Technologies, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, JR.
  • Patent number: 7883541
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: February 8, 2011
    Assignee: RTI Biologics, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Patent number: 7648676
    Abstract: The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: January 19, 2010
    Assignee: RTI Biologics, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, Chandrasekaran Nataraj
  • Patent number: 7214464
    Abstract: The present invention is directed to a method of forming a positive image in a photothermographic assembly comprising a photothermographic material and an intensifying means for converting ionizing radiation, wherein the assembly has been imagewise exposed to ionizing radiation to form a latent image in the photothermographic material. The photothermographic material has at least one imaging layer comprising a potentially negative-working emulsion, wherein thermal development of unexposed silver salts in exposed areas relative to unexposed areas is inhibiting when thermally developing the imagewise exposed assembly, thereby producing a positive image. The present invention is also directed to a photothermographic assembly that can be used in the present process in which a positive image characterized by high speed and discrimination is formed when exposed and thermally heated above 150° C.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: May 8, 2007
    Assignee: Eastman Kodak Company
    Inventors: Michael R. Roberts, Kurt D. Sieber, Paul B. Gilman, Jr.
  • Patent number: 7198889
    Abstract: The present invention is directed to a method of forming a positive image in a photothermographic element comprising a potentially negative-working emulsion wherein fog density development is imagewise inhibited in exposed areas of the image upon thermal development, the element further comprising a developer or precursor thereof and an oxidized developer scavenging agent to accelerate development by removing oxidized developer as it is formed during the thermal development step. In one embodiment of the invention, in which a density-inhibiting agent is released during thermal development that inhibits the thermal development of unexposed silver salts in the exposed areas relative to the unexposed areas, the method comprises imagewise exposing the film with a non-solarizing amount of radiation/energy to form a latent image and thermally developing the latent image in a single development step to produce a positive image in the element.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: April 3, 2007
    Assignee: Eastman Kodak Company
    Inventors: Michael R. Roberts, Paul B. Gilman, Donald L. Black, Kurt M. Schroeder
  • Patent number: 7183024
    Abstract: The present invention is directed to a method of forming a positive image in a photothermographic element comprising a potentially negative-working emulsion wherein fog density development is imagewise inhibited in exposed areas of the image upon thermal development. In one embodiment of the invention, a density-inhibiting agent is released during thermal development which agent inhibits the thermal development of unexposed silver salts in the exposed areas relative to the unexposed areas. The method preferably comprises imagewise exposing the film with a non-solarizing amount of radiation/energy to form a latent image and thermally developing the latent image in a single development step to produce a positive image in the element. The present invention is also directed to a photothermographic element that can be used in the present process in which a positive image characterized by high speed and discrimination is formed when exposed and thermally heated above 150° C.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: February 27, 2007
    Assignee: Eastman Kodak Company
    Inventors: Michael R. Roberts, Paul B. Gilman, Donald L. Black, Kurt M. Schroeder
  • Patent number: 7131994
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic agent to attract a desired cell.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: November 7, 2006
    Assignee: Regeneration Technologies, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Patent number: 7033742
    Abstract: The present invention is directed to a method of forming a positive image in a photothermographic film exposed by electrons in a transmission electron microscope to form a latent image in the film. The photothermographic film has at least one imaging layer comprising a potentially negative-working emulsion, but wherein thermal development of unexposed silver salts in exposed areas relative to unexposed areas is inhibited when thermally developing the imagewise exposed assembly, thereby producing a positive image. The present invention is also directed to the processing of the photothermographic film in which a positive image characterized by high speed and discrimination is formed in the film when heated above 150° C.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: April 25, 2006
    Assignee: Eastman Kodak Company
    Inventors: Michael R. Roberts, Donald L. Black, Paul B. Gilman, Jr.
  • Patent number: 7001430
    Abstract: The present invention is directed to an intermediate composition for producing a muscle tissue matrix suitable for implantation in humans, comprising shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier, preferably a biocompatible acid solution, to form a muscle tissue slurry having a viscosity within the range of 1 centistoke to 20,000 centistokes measured at 25° C. In another aspect, the present invention is directed to a tissue implant comprising a human muscle tissue matrix.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: February 21, 2006
    Assignee: Regeneration Technologies, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.