Patents by Inventor Michael R. Slater

Michael R. Slater has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression
    Patent number: 8748148
    Abstract: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: June 10, 2014
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance P. Encell, Rachel Friedman Ohana, Paul Otto, Gediminas Vidugiris, Keith V. Wood, Monika G. Wood, Kris Zimmerman, Michael R. Slater, Kate Qin Zhao
  • Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use
    Patent number: 8669103
    Abstract: An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: March 11, 2014
    Assignee: Promega Corporation
    Inventors: Brock Binkowski, Lance P. Encell, Mary Hall, Matthew B. Robers, Michael R. Slater, Keith V. Wood, Monika G. Wood
  • POLYNUCLEOTIDES ENCODING MUTANT HYDROLASE PROTEINS WITH ENHANCED KINETICS AND FUNCTIONAL EXPRESSION
    Publication number: 20130302880
    Abstract: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
    Type: Application
    Filed: April 16, 2013
    Publication date: November 14, 2013
    Applicant: PROMEGA CORPORATION
    Inventors: Aldis Darzins, Lance P. Encell, Rachel Friedman Ohana, Paul Otto, Gediminas Vidugiris, Keith V. Wood, Monika G. Wood, Kris Zimmerman, Michael R. Slater, Kate Qin Zhao
  • Vectors for directional cloning
    Publication number: 20130183760
    Abstract: The invention provides vectors and methods for directional cloning.
    Type: Application
    Filed: October 17, 2011
    Publication date: July 18, 2013
    Applicant: PROMEGA CORPORATION
    Inventors: Michael R. Slater, Keith V. Wood, James Robert Hartnett
  • Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression
    Patent number: 8420367
    Abstract: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: April 16, 2013
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance P. Encell, Rachel Friedman Ohana, Paul Otto, Gediminas Vidugiris, Keith V. Wood, Monika G. Wood, Kris Zimmerman, Michael R. Slater, Kate Qin Zhao
  • Vectors for directional cloning
    Patent number: 8367403
    Abstract: The invention provides vectors and methods for directional cloning.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: February 5, 2013
    Assignee: Promega Corporation
    Inventors: Michael R. Slater, Ethan Edward Strauss, Keith V. Wood, James Robert Hartnett
  • Vectors for directional cloning
    Patent number: 8293503
    Abstract: The invention provides vectors and methods for directional cloning.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: October 23, 2012
    Assignee: Promega Corporation
    Inventors: Michael R. Slater, Ethan Edward Strauss, Keith V. Wood, James Robert Hartnett
  • OPLOPHORUS-DERIVED LUCIFERASES, NOVEL COELENTERAZINE SUBSTRATES, AND METHODS OF USE
    Publication number: 20120174242
    Abstract: An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
    Type: Application
    Filed: November 2, 2011
    Publication date: July 5, 2012
    Inventors: Brock Binkowski, Lance P. Encell, Mary Hall, Matthew B. Robers, Michael R. Slater, Keith V. Wood, Monika G. Wood
  • VECTORS FOR DIRECTIONAL CLONING
    Publication number: 20100216231
    Abstract: The invention provides vectors and methods for directional cloning.
    Type: Application
    Filed: December 28, 2009
    Publication date: August 26, 2010
    Inventors: Michael R. Slater, Ethan Edward Strauss, Keith V. Wood, James Robert Hartnett
  • Mutant hydrolase proteins with enhanced kinetics and functional expression
    Publication number: 20080145882
    Abstract: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 19, 2008
    Inventors: Aldis Darzins, Lance P. Encell, Rachel Friedman Ohana, Paul Otto, Gediminas Vidugiris, Keith V. Wood, Monika G. Wood, Kris Zimmerman, Michael R. Slater, Kate Qin Zhao
  • Thermophilic DNA polymerases from Thermotoga neapolitana
    Publication number: 20040132985
    Abstract: The present invention relates to thermostable DNA polymerases derived from the hyperthermophilic eubacteria, and Thermotoga neapolitana in particular. The present invention provides means for isolating and producing the enzymes from these thermostable DNA polymerases, which are useful in many recombinant DNA techniques, especially such techniques as thermal cycle sequencing and nucleic acid amplification.
    Type: Application
    Filed: November 12, 2003
    Publication date: July 8, 2004
    Inventors: Elena Bolchakova, Alexander Novikov, Michael R. Slater, Fen Huang, James R. Hartnett, Galina A. Velikodvorskaya
  • Method to enhance homologous recombination
    Publication number: 20030228608
    Abstract: The invention relates to methods for enhancing the targeting of exogenous polynucleotides to a preselected target sequence in a target cell or in an extrachromosomal sequence.
    Type: Application
    Filed: April 15, 2003
    Publication date: December 11, 2003
    Applicant: Promega Corporation
    Inventors: Rachel Friedman-Ohana, Michael R. Slater, Nigel John Grinter
  • Thermophilic DNA polymerases from Thermotoga neapolitana
    Patent number: 6077664
    Abstract: The present invention relates to compositions of thermostable DNA polymerases derived from the hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterium known as Thermotoga neapolitana. The present invention provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. neopolitana DNA polymerase. The T. neopolitana DNA polymerases of the present invention are used in combination with other compounds, including but not limited to pyrophosphatase and DNA polymerases from other thermophilic or hyperthermophilic organisms.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: June 20, 2000
    Assignee: Promega Corporation
    Inventors: Michael R. Slater, Fen Huang, James R. Hartnett, Elena Bolchakova, Douglas R. Storts, Paul Otto, Katharine M. Miller, Alexander Novikov, Galina A. Velikodvorskaya
  • Thermophilic DNA polymerases from thermotoga neapolitana
    Patent number: 6001645
    Abstract: The present invention relates to thermostable DNA polymerases derived from the hyperthermophilic eubacteria, and Thermotoga neapolitana in particular. The present invention provides means for isolating and producing the enzymes from these thermostable DNA polymerases, which are useful in many recombinant DNA techniques, especially such techniques as thermal cycle sequencing and nucleic acid amplification.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 14, 1999
    Assignee: Promega Corporation
    Inventors: Michael R. Slater, Fen Huang, James R. Hartnett
  • Computer representation of nucleotide and protein sequences
    Patent number: 5187775
    Abstract: A display system for use on a digital computer is specifically designed to display information about nucleotide sequences, such as DNA sequences and the protein or amino acid sequences associated with those nucleotide sequences. The system uses a specially adapted font which includes special three letter characters representing the amino acids. The letters in the special characters are kerned for compact presentation. The use of such three letter characters, created to be of a width three times that of the remaining monospace characters in the font, allows amino acid sequences to be stored and presented with the corresponding nucleotide sequences in such a fashion that they are properly aligned and also usually legible.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: February 16, 1993
    Assignee: Dnastar, Inc.
    Inventors: John L. Schroeder, Michael R. Slater