Patents by Inventor Michael Randall

Michael Randall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12167896
    Abstract: In one aspect, a system for endovascular treatment of a blood vessel includes a control unit, an ultrasound device, an actuator, and a catheter having a treatment portion. The ultrasound device is communicatively coupled to the control unit. The ultrasound device includes an ultrasound probe having a subject contact surface. The actuator is coupled to the ultrasound probe and is operable to move the subject contact surface of the ultrasound prove relative to a treatment zone of a subject. The control unit is configured to determine a position of the treatment portion of the catheter as the catheter is advanced through the blood vessel, and move the subject contact surface of the ultrasound probe relative to the treatment zone of the subject with the actuator to follow the position of the catheter as the catheter is advanced through the blood vessel.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: December 17, 2024
    Assignee: TVA Medical, Inc.
    Inventors: Peng Zheng, Alexander W. Tessmer, Jeremy B. Cox, Andrzej J. Chanduszko, Michael Randall, Thomas Diffley Pate
  • Patent number: 11950800
    Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: April 9, 2024
    Assignee: C.R. BARD, INC.
    Inventors: Andrzej Chanduszko, Michael Randall, Chad Van Liere
  • Patent number: 11759151
    Abstract: Methods and systems are provided for measuring anatomical dimensions from a single two-dimensional (2D) digital image. The digital image is taken from the front/anterior view using a mobile, handheld communication device. The linear measurements are used to estimate the body volume of the individual. Total body density is calculated from estimated body volume and body weight. Body composition (fat mass and fat-free mass) of the individual is derived from density using known mathematical conversion formulas. A method for estimating body composition analysis is provided.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: September 19, 2023
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
    Inventors: Michael Vernon Fedewa, Michael Randall Esco
  • Publication number: 20230181456
    Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents.
    Type: Application
    Filed: January 25, 2023
    Publication date: June 15, 2023
    Inventors: Elena Afonina, Hiep Do, Emily Goel, Oleg Guryev, Cyal Lecy, Majid Mehrpouyan, Michael Randall, Marybeth Sharkey, Jeffrey Wang
  • Publication number: 20230172859
    Abstract: Methods for preparing a drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. The drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy.
    Type: Application
    Filed: February 7, 2023
    Publication date: June 8, 2023
    Applicant: C.R. Bard, Inc.
    Inventors: Hiep Do, Michael Randall
  • Patent number: 11607388
    Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy. Methods for preparing the drug-loaded microbead compositions and the embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 21, 2023
    Assignee: C.R. Bard, Inc.
    Inventors: Hiep Do, Michael Randall
  • Patent number: 11590080
    Abstract: Drug-loaded microbead compositions include microbeads of a biodegradable material and vesicular agents located within or associated with the biodegradable material of the microbeads. The vesicular agents include a lipid bilayer and comprise liposomes or ethosomes. The drug-loaded microbeads include a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 28, 2023
    Assignee: C.R. Bard, Inc.
    Inventors: Elena Afonina, Hiep Do, Emily Goel, Oleg Guryev, Cyal Lecy, Majid Mehrpouyan, Michael Randall, Marybeth Sharkey, Jeffrey Wang
  • Publication number: 20220401239
    Abstract: An endovascular apparatus takes the form of an expandable tubular body having a retriever, which may include a pair of interconnected hooks. The retriever may be formed from a single piece of material forming the tubular body, and in the case of a pair of hooks thus has a thickness corresponding to approximately twice the wall thickness of the tubular body. The innermost radial portion of the hooks may be offset from a central axis of a lumen formed by the tubular body, which facilitates free insertion of a balloon or the like for purposes of expanding the tubular body. Related methods of manufacturing an endovascular apparatus with a retriever are also described herein.
    Type: Application
    Filed: March 2, 2022
    Publication date: December 22, 2022
    Inventors: Andrzej J. CHANDUSZKO, Michael Randall, William Parmentier
  • Patent number: 11511097
    Abstract: Provided herein is a system including, in some embodiments, a streamlined port and a port tunneler. The port includes a septum and a stabilizing element. The septum is disposed over a cavity in a body of the port, and the septum is configured to accept a needle therethrough. The stabilizing element is configured to stabilize the port in vivo and maintain needle access to the septum. The port tunneler includes an adapter and a release mechanism. The adapter is in a distal end portion of the port tunneler, and the adapter is configured to securely hold the port while subcutaneously tunneling the port from an incision site to an implantation site for the port. The release mechanism is configured to release the port from the adapter at the implantation site for the port.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 29, 2022
    Assignee: C. R. Bard, Inc.
    Inventors: Jeremy B. Cox, James D. Meler, II, Michael Randall, Chad Van Liere
  • Publication number: 20220323353
    Abstract: Drug-loaded microbead compositions including a plurality of individual microbeads of a biodegradable material, a plurality of individual vesicular agents, a first therapeutic agent, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include at least one lipid bilayer surrounding a vesicular core. The first therapeutic agent is associated with the individual vesicular agents. For example, the first therapeutic agent may be contained within the individual vesicular agents or may be associated with the individual vesicular agents by ionic or non-covalent interaction. The second therapeutic agent is different from the first therapeutic agent and contained within the individual microbeads or associated with the individual microbeads through ionic or non-covalent interaction. The second therapeutic agent may or may not be associated with the individual vesicular agents.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 13, 2022
    Inventors: Elena Afonina, Hiep Q Do, Emily Goel, Oleg Guryev, Cyal Lecy, Majid Mehrpouyan, Michael Randall, Marybeth Sharkey, Jeffrey Wang
  • Publication number: 20220280244
    Abstract: In one aspect, a system for endovascular treatment of a blood vessel includes a control unit, an ultrasound device, an actuator, and a catheter having a treatment portion. The ultrasound device is communicatively coupled to the control unit. The ultrasound device includes an ultrasound probe having a subject contact surface. The actuator is coupled to the ultrasound probe and is operable to move the subject contact surface of the ultrasound prove relative to a treatment zone of a subject. The control unit is configured to determine a position of the treatment portion of the catheter as the catheter is advanced through the blood vessel, and move the subject contact surface of the ultrasound probe relative to the treatment zone of the subject with the actuator to follow the position of the catheter as the catheter is advanced through the blood vessel.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 8, 2022
    Applicant: TVA Medical, Inc.
    Inventors: Peng Zheng, Alexander W. Tessmer, Jeremy B. Cox, Andrzej J. Chanduszko, Michael Randall, Thomas Diffley Pate
  • Patent number: 11285027
    Abstract: An endovascular apparatus takes the form of an expandable tubular body having a retriever, which may include a pair of interconnected hooks. The retriever may be formed from a single piece of material forming the tubular body, and in the case of a pair of hooks thus has a thickness corresponding to approximately twice the wall thickness of the tubular body. The innermost radial portion of the hooks may be offset from a central axis of a lumen formed by the tubular body, which facilitates free insertion of a balloon or the like for purposes of expanding the tubular body. Related methods of manufacturing an endovascular apparatus with a retriever are also described herein.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: March 29, 2022
    Assignee: C.R. Bard, Inc.
    Inventors: Andrzej J. Chanduszko, Michael Randall, William Parmentier
  • Patent number: 11166121
    Abstract: Systems and methods are provided for receiving a first message associated with a first sponsor and a second message associated with a second sponsor for inclusion in a message collection. The systems and methods determine a first priority parameter associated with the first message based on sponsored content, and a second priority parameter associated with the second message based on sponsored content. Based on a determination that there is insufficient message inventory to include both the first message and the second message in the message collection, the systems and methods prioritize the first message associated with the first sponsor in the message collection and excluding the second message associated with the second sponsor in the message collection, based on an amount of consideration associated with the first priority parameter received from the first sponsor and an amount of consideration associated with the second priority parameter received from the second sponsor.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: November 2, 2021
    Assignee: Snap Inc.
    Inventors: Timothy Michael Sehn, Juan David Borrero, Michael Randall, Brian Ames
  • Publication number: 20210315606
    Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 14, 2021
    Inventors: Andrzej Chanduszko, Michael Randall, Chad Van Liere
  • Patent number: 11039853
    Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 22, 2021
    Assignee: C.R. Bard, Inc.
    Inventors: Andrzej Chanduszko, Michael Randall, Chad Van Liere
  • Publication number: 20210113235
    Abstract: A catheter for scoring or slicing a lesion. The catheter has a first receiver at a distal end of an expandable portion of the catheter shaft. A first carrier at least partially within the first receiver is moveable axially along the catheter shaft to deploy a first cutter along the expandable portion for cutting or scoring the lesion. In an alternative embodiment, the first carrier may be a wire having a loop, and thus forming a first length including the first cutter and a second length including a second cutter. Actuation of the wire thus causes simultaneous, reciprocal movement of the first and second cutters. Related methods are also disclosed.
    Type: Application
    Filed: August 6, 2018
    Publication date: April 22, 2021
    Inventors: Andrzej Chanduszko, Michael Randall, Chad Van Liere
  • Publication number: 20210052499
    Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents.
    Type: Application
    Filed: June 26, 2020
    Publication date: February 25, 2021
    Inventors: Elena Afonina, Hiep Do, Emily Goel, Oleg Guryev, Cyal Lecy, Majid Mehrpouyan, Michael Randall, Marybeth Sharkey, Jeffrey Wang
  • Publication number: 20210045769
    Abstract: Dual-access site catheter systems with a blade or scoring functionality entering through a first access site and a balloon functionality for manipulating or driving the blade or scoring functionality through a different site. The blade or scoring functionality also sometimes provides needle or fluid delivery functionality to an atherosclerotic lesion.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 18, 2021
    Inventors: Michael Randall, Chad Van Liere, Andrzej J. Chanduszko
  • Publication number: 20200390707
    Abstract: Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy. Methods for preparing the drug-loaded microbead compositions and the embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads.
    Type: Application
    Filed: December 18, 2018
    Publication date: December 17, 2020
    Inventors: Hiep Do, Michael Randall
  • Publication number: 20200345314
    Abstract: Methods and systems are provided for measuring anatomical dimensions from a single two-dimensional (2D) digital image. The digital image is taken from the front/anterior view using a mobile, handheld communication device. The linear measurements are used to estimate the body volume of the individual. Total body density is calculated from estimated body volume and body weight. Body composition (fat mass and fat-free mass) of the individual is derived from density using known mathematical conversion formulas. A method for estimating body composition analysis is provided.
    Type: Application
    Filed: April 7, 2020
    Publication date: November 5, 2020
    Inventors: Michael Vernon Fedewa, Michael Randall Esco