Abstract: A single-cell transition signature is accessed that represents differential cellular-component expression between a first and altered cell state. The altered state occurs through cellular transition from the first to altered cell state. The transition signature comprises an identification of a plurality of cellular-components and, for each such cellular-component, a corresponding first significance score quantifying an association between a change in expression of the respective cellular-component and a change in cell state between the first and altered cell state. The transition signature is compared to a perturbation signature representing differential cellular-component expression between unperturbed cells and perturbed cells exposed to the perturbation.

Abstract: An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.

Abstract: The present invention may be used for pressing product and draining liquid from canned food such as tuna, drain liquids from canned food such as fruit and vegetables and press out a meat patty such as hamburger and sausage. A cap may have a press attached through a center top hole to the cap. The cap may have a width and height to fit most size canned food. The cap may have a top side drain hole. The press may have a top and a bottom piece that may attach together through center top hole of the cap.

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Abstract: Embodiments of the disclosed technologies include a method of capturing, using a mobile device, a best-focused image of a skin surface of a subject, the method including: setting a camera of the mobile device to a fixed focal length; capturing, using the camera, a current image of a plurality of images of the skin surface, the plurality of images having a sequence and including a first previous image captured, using the camera, previously to the current image and a second previous image captured, using the camera, previously to the first previous image; producing a modified image from the current image; transforming the modified image, using a Laplacian pyramid, to produce a plurality of first luminance values from the modified image and a plurality of second luminance values from the plurality of first luminance values; averaging a plurality of first squared values, each including a square of a corresponding first luminance value of the plurality of first luminance values, to produce a first energy value; av

Abstract: Device logic in a mobile device configures a processor to capture a series of images, such as a video, using a consumer-grade camera, and to analyze the images to determine the best-focused image, of the series of images, that captures a region of interest. The images may be of a textured surface, such as facial skin of a mobile device user. The processor sets a focal length of the camera to a fixed position for collecting the images. The processor may guide the user to position the mobile device for capturing the images, using audible cues. For each image, the processor crops the image to the region of interest, extracts luminance information, and determines one or more energy levels of the luminance via a Laplacian pyramid. The energy levels may be filtered, and then are compared to energy levels of the other images to determine the best-focused image.

Abstract: A sizing forceps is provided for fixing a nerve in place, measuring the diameter of the nerve, and providing an efficient way to resect the nerve. A sizing forceps can have an upper and lower jaw with one or more aligned notches that form apertures for holding a nerve. The apertures can have predetermined sizes that can be used to measure the diameter of a nerve. A slicing slot in the upper and lower jaw allows a nerve within an aperture to be severed to obtain a non-frayed end.

Abstract: A pressure relief valve flap includes an attachment portion, a main portion, and a hinge portion. The attachment portion is configured to be attached to the housing. The main portion has a lip and at least one damping feature. The lip extends around at least a portion of a periphery of the main portion. The hinge portion is disposed between and connects the main portion and the attachment portion. When the attachment portion is attached to the housing, the main portion is configured to move between a closed position and an opened position. When the main portion moves from the opened position to the closed position, the at least one damping feature is configured to engage the housing prior to the lip of the main portion and thereby dampen noise created when the lip of the main portion engages the housing.

Abstract: A linear encoder may be used to accurately determine a number of cartridges within a magazine. Further, using a set of magnetic sensors within a buffer tube of a firearm, it is possible to determine whether a cartridge is loaded within a chamber of the weapon and/or whether the firearm is jammed. The determination of cartridges within the magazine in conjunction with the determination of whether a cartridge is in a chamber of a firearm can give a user an accurate ammunition count. Further, the use of the linear encoder makes it possible to accurately determine the cartridge count when different cartridges are loaded into the magazine or when the magazine degrades in quality over time. Moreover, the ability for magazines to communicate with a firearm enables a user to determine a total available ammunition to the user in a single display without individually checking each magazine.

Abstract: A pressure relief assembly (100) includes a housing (102) including an air passage chamber (104) having a flap barrier (122) surrounding at least one airflow passage. A membrane flap is secured within the air passage chamber. The membrane flap covers the airflow passage(s) in a closed position. A portion of the membrane flap is configured to move off the airflow passage(s) into an open position. A noise-dampening seal (120) formed of a noise-dampening material is proximate to at least a portion of the flap barrier. The noise-dampening seal is configured to reduce noise generated by movement of the membrane flap as the membrane flap moves from the open position to the closed position. The noise-dampening seal provides a sealing interface with the membrane flap in the closed position.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract: A method of converting a standard toner printer to a security toner printer, comprising the steps: providing a standard toner printer; removing one or more of the toner printing cartridges from the standard toner printer, such that at least one printing cartridge position is empty and there is at least one removed toner printing cartridge; providing one or more empty replacement toner printing cartridges; filling at least one of the one or more empty replacement toner printing cartridges with a mixture of a toner and a taggant, such that one or more security replacement toner printing cartridges are created; wherein the taggant is configured to be detected by a security reader; and installing the one or more security replacement toner printing cartridges into the at least one empty printing cartridge position.

Abstract: A vaporizing apparatus includes a mouthpiece, battery and a reservoir housing an intake tube forming an air passage and vaporizing chamber proximal the battery. The vaporizing chamber also includes an inlet and vaporizing element completing an electric circuit with the battery for heating. A vapor outlet tube extends through the air passage, terminating in the vaporizing chamber adjacent the vaporizing element, and an air intake proximal the mouthpiece allows suction from the mouthpiece to urge air from the air intake through the air passage to join a vaporizable material urged through the inlet in the vaporizing chamber, vaporizing the vaporizable material with vapor exiting the mouthpiece through the vapor outlet tube.

Abstract: An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.

Abstract: A system and method serve to a user a login menu that is executed on a computing device, wherein the login menu is programmed to acquire from a user a set of parameters for access to a facility computing environment. In response to receiving credentials corresponding to the user, displaying, using the computing device, at least one graphical user interface that allows the user to participate in at least one activity corresponding to the facility, wherein the at least one activity is based in part on the credentials and one or more tasks available at the facility, and wherein the one or more tasks are verified for the user. The system and method generate, using the computing device, one or more points in real-time or near real-time for the user, during execution of the at least one activity at the computing device, wherein the at least one point is based on at least one achievement corresponding to the activity.

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: Systems, Methods, and Apparatuses for an image sensor and a control system to cooperate with each photodiode in individual pixels to allow multiple pixels in a set of pixels to operate in a different imaging-mode of operation simultaneously within multiple window regions of the image. The image sensor has multiple window regions each capable of operating in different operating modes. Each pixel contains multiple photodiodes. The imager is fabricated with an additional semiconductor layer containing one or more metallization layers for interconnections and providing active CMOS circuits for control.

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract: A method of converting a CMYK color toner printer to a CMYX color toner printer for under print printing in a single pass, comprising the steps: providing a color toner printer with four toner printing cartridges: a cyan toner printing cartridge, a magenta toner printing cartridge, a yellow toner printing cartridge, and a black toner printing cartridge; wherein the black toner printing cartridge is in a first toner cartridge position; removing the back toner printing cartridge from the first toner cartridge position; providing a non-standard toner printing cartridge; installing the non-standard toner printing cartridge into the first toner cartridge position; providing a raster image processor software; wherein the raster image processor software is configured to remap the four toner printing cartridges of the color toner printer and allows the color toner printer to print a layer of non-standard toner under an image in a single pass; and wherein the image is printed from at least one of a cyan toner, a yello

Abstract: A system and method for measuring noise parameters of a linear device-under-test is provided. The system includes a noise source, an impedance generator, a receiver for measuring noise power of the device-under-test, and a processor and memory. The impedance generator has a plurality of impedance generator settings to generate a plurality of driving-port impedances over a plurality of frequencies. The processor is configured for identifying a plurality of stable driving-port impedances, calculating an aggregate driving-port impedance for each of the stable driving-port impedances, identifying a minimal set of impedance generator settings for a user-selected frequency range, and calculating the noise parameters of the device-under-test based on the noise power measured by the receiver. The minimal set of impedance generator settings provide at least one aggregate driving-port impedance located within each of four linearly independent regions of a Smith Chart over the user-selected frequency range.