Abstract: A folding knife is provided with a deflectable pivot that provides a varying bias force as the blade is rotated between the closed and open positions. Specifically, the pivot secures the blade to bias members of a handle, and the bias members deform relative to other parts of the handle to allow the pivot to move and to provide the varying bias force. A cam surface on the tang of the blade operatively engages a pin of the handle to control the deflection of the pivot and the bias members. The cam surface and the resulting bias force are arranged to locate and keep the blade in the open or closed positions like a detent mechanism to reduce the likelihood of an unintentional opening or closing of the blade and to improve the safety of the folding knife.

Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Abstract: A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye wherein the ocular benefit composition comprises at least 5 wt % of one or more lipid and/or lipid derived compounds.

Abstract: A coupled cavity traveling wave tube has periodic permanent magnet (PPM) RF cavity structures, each of which has a plurality of permanent magnets placed substantially equidistant from a central axis, and which are outside the extent of a plurality of electron beam tunnels arranged substantially equidistant from the central axis and within the extents of the plurality of permanent magnets. Each coupled cavity RF structure is formed by adjacent ferrous polepieces and a cylindrical wall which is beyond the extent of one or more coupling apertures which couple RF energy from one coupled cavity structure to an adjacent RF cavity.

Abstract: Phenotyping of cells involves loading a biological sample into a microfluidic device (1, 100) comprising cell compartments (20, 120) to capture biological material, including target cells, in the sample in the cell compartments (20, 120). A subset (20A) of the cell compartments (20, 120) is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments (20, 120) prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (20A) of the cell compartments (20, 120). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Abstract: A compact wheel loader having a hydrostatic transmission and two modes of operation. In a normal mode, a demand lever is used to set the engine speed, and displacement of the swash plate of the hydraulic pump of the transmission is set by a hydraulic pilot pressure (Ps) that increases with engine speed, so that the transmission ratio automatically decreases as the engine speed increased. In a creeper mode, the engine is set to operate at a high speed to meet the demand of powered implements of the loader, and the wheel speed is controlled by the demand lever setting the transmission ratio by varying the hydraulic pilot pressure (Ps).

Abstract: A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye wherein the ocular benefit composition comprises at least 5 wt % of one or more lipid and/or lipid derived compounds.

Abstract: A compact wheel loader having a hydrostatic transmission and two modes of operation. In a normal mode, a demand lever is used to set the engine speed, and displacement of the swash plate of the hydraulic pump of the transmission is set by a hydraulic pilot pressure (Ps) that increases with engine speed, so that the transmission ratio automatically decreases as the engine speed increased. In a creeper mode, the engine is set to operate at a high speed to meet the demand of powered implements of the loader, and the wheel speed is controlled by the demand lever setting the transmission ratio by varying the hydraulic pilot pressure (Ps).

Abstract: A periodic permanent magnet (PPM) klystron has beam transport structures and RF cavity structures, each of which has permanent magnets placed substantially equidistant from a beam tunnel formed about the central axis, and which are also outside the extent of a cooling chamber. The RF cavity sections also have permanent magnets which are placed substantially equidistant from the beam tunnel, but which include an RF cavity coupling to the beam tunnel for enhancement of RF carried by an electron beam in the beam tunnel.

Abstract: In one or more embodiments, the present disclosure provides for a process for preparing a dispersion of starch particles in an aqueous liquid. In one or more embodiments, the process includes introducing a feed starch and the aqueous liquid into a rotor stator mixer, maintaining the feed starch and the aqueous liquid in the rotor stator mixer at a temperature ranging from a gelation temperature to less than a solubilization temperature, and shearing the feed starch into starch particles with the rotor stator mixer to form the dispersion of starch particles in the aqueous liquid. In one or more embodiments, the starch particles produced by this process have an average particle size diameter of no larger than 2 micrometers and the dispersion has 20 to 65 weight percent of the starch particles based on a total weight of the dispersion.

Abstract: A multi-beam electron gun provides a plurality N of cathode assemblies comprising a cathode, anode, and focus electrode, each cathode assembly having a local cathode axis and also a central cathode point defined by the intersection of the local cathode axis with the emitting surface of the cathode. Each cathode is arranged with its central point positioned in a plane orthogonal to a device central axis, with each cathode central point an equal distance from the device axis and with an included angle of 360/N between each cathode central point.

Abstract: Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.

Abstract: Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.

Abstract: A nozzle chip (3) for ejecting a liquid such as in an electrospray device is built from a substrate chip having grooves (5, 7) on a top surface. A lid (25) is attached to the top surface closing the grooves to form channels one of which has an open outlet end (9). At the outlet end a nozzle is formed at or attached and it has an outlet opening from which the liquid is to be ejected. Alignment recesses (13, 15) are made at edges of the substrate chip and they are accurately positioned in relation to the outlet opening, the alignment recesses allowing an accurate mounting of nozzle chip giving the outlet opening of the nozzle a reproducible position in the device where it is to be used. At the outlet end a recess (17) in the substrate chip can be provided and the nozzle can then be located in the recess to mechanically protect it.

Abstract: The invention provides novel lipid soluble forms of tricyclic antineoplastic compounds. These forms include salts, co-crystals, and solvates of the tricyclic antineoplastic compounds. The invention also provides novel pharmaceutical compositions comprising these novel lipid soluble forms and related methods of treatment. Compositions and methods of the invention are useful in the treatment of neoplasms, including MRP-1-related resistant neoplasms.

Abstract: Engine speed data (N) and engine fueling data (MFDES) are processed to develop rate-of change data values for both engine fueling (FUELING_DIFFERENCE_FILTERED) and engine speed (ENGINE SPEED_DIFFERENCE_FILTERED). The latter are processed according to a look-up table (30) to select a data value for an adder (ENGINE SPEED/FUELING_ROC_ADDER). The adder data value is added to the data value of a control parameter, such as engine fueling (MFDES), to compensate for engine transients.

Abstract: The invention relates to polymers derived from macrocyclic oligomers containing organo clay fillers. The invention also relates to processes for preparing such compositions. Furthermore, the invention relates to articles prepared from organoclay filled polymer compositions.

Abstract: Manufacturing of miniaturised three-dimensional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro-replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.

Abstract: A method of forming a branch-off seal between a heat-shrinkable sleeve and at least two spaced-apart elongate substrates, which comprises the steps of:(a) positioning the substrates within the heat-shrinkable sleeve;(b) positioning between the substrates and within the sleeve at an open end thereof a plug having a larger cross-sectional size at a first position away from said open end and a smaller cross-sectional size at a second position towards said open end;(c) positioning a heat-activatable sealing material at the first position;(d) shrinkable conduits in the sleeve by positioning one or more clips at the open end of the sleeve such that the substrates and the plug are in respective conduits; and(e) while the clip remains on the sleeve, applying heat so as to affect shrinkage of the sleeve to activate the sealant, and form the desired seal.