Patent number: 6699896
Abstract: This invention provides compounds having the structure
wherein
A is OR5, or
R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl,
R2 is H, alkyl, or aryl; R3 and R4 are halo, H, alkyl, aryl, trifluoromethyl, alkoxyaryl, nitro, amino, carboalkoxy, carbamide, carbamate, urea, alkylsulfonamide, —NR7(CH2)mCO2H, arylsulfonamide, cycloalkyl, or a heterocycle; R5 is H, alkyl, —CH(R8)R9, —CH2(CH2)nCO2R10, —C(CH3)2CO2R10, —CH(R8)(CH2)nCO2R10, —CH(R8)C6H4CO2R10, or —CH2-tetrazole; R6 is H, alkyl, halo, alkoxy, trifluoroalkyl or trifluoroalkoxy; R7 is H or alkyl; R8 is H, alkyl, aryl, arylalkyl, cycloalkyl, phthalic acid,
R9 is CO2R12, CONHR12, tetrazole, or PO3R12; R10 is H, alkyl, aryl, or aralkyl;
R11 is alkyl; R12 is H, alkyl, aryl, or aralkyl; X is O, or S; Y is O, N, or S; Z is C, or N;
Q is O, N, or S; m=1-3; n=1-6, or a pharmaceutically acceptable salt thereof, which
Type:
Grant
Filed:
May 10, 1999
Date of Patent:
March 2, 2004
Assignee:
Wyeth
Inventor:
Michael S. Malamas