Abstract: Alpha-amino boronic acid derivatives are useful for selectively inhibiting the activity of immunoproteasome subunit LMP7 and for the treatment of medical conditions affected by immunoproteasome activity such as blood disorders and solid tumors, which are defined by specific genetic alterations and/or inadequate responsiveness to other therapeutic treatments. In particular, the compounds disclosed herein are selective LMP7 inhibitors, which may be useful alone or in combination for the treatment of blood disorders, such as multiple myeloma, and certain solid tumors.

Abstract: This disclosure details cooling systems for cooling electric components, such as electric machines, within electrified vehicles. Exemplary cooling systems may include a spray bar positioned relative to a rear face of a stator of the electric machine. In some embodiments, the spray bar may be positioned axially between the rear face of the stator and a torque converter housing. One or more nozzles of the spray bar are configured to direct a coolant between adjacent back irons of the stator, onto end windings of the stator, or both. Actively cooling the stator allows the electric machine to operate at higher torques and speeds, thereby increasing performance.

Abstract: Methods and systems for an electric motor-generator in a vehicle are provided. In one example, an electric motor-generator is provided that includes an engine interface configured to rotationally couple to a first engine, a transmission interface configured to rotationally couple to a first transmission of the first engine, and a rotor with a plurality of magnets at least partially surrounding a stator including a plurality of coils. The rotor is rotationally coupled to the engine interface and the transmission interface.

Abstract: Methods and systems are provided for a coolant pump. In one example, the coolant pump may be a dual-volute coolant pump with an impeller driving circulation of coolant through the pump and a seal disposed around a shaft of the impeller. A set of anti-vortex structures may be arranged within an inner chamber of the pump, the structures generating a pressure differential in the inner chamber that drives a cross-flow of coolant, thereby convectively cooling the seal.

Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: Methods and systems for an electric motor-generator in a vehicle are provided. In one example, an electric motor-generator is provided that includes an engine interface configured to rotationally couple to a first engine, a transmission interface configured to rotationally couple to a first transmission of the first engine, and a rotor with a plurality of magnets at least partially surrounding a stator including a plurality of coils. The rotor is rotationally coupled to the engine interface and the transmission interface.

Abstract: This disclosure details cooling systems for cooling electric components, such as electric machines, within electrified vehicles. Exemplary cooling systems may include a spray bar positioned relative to a rear face of a stator of the electric machine. In some embodiments, the spray bar may be positioned axially between the rear face of the stator and a torque converter housing. One or more nozzles of the spray bar are configured to direct a coolant between adjacent back irons of the stator, onto end windings of the stator, or both. Actively cooling the stator allows the electric machine to operate at higher torques and speeds, thereby increasing performance.

Abstract: This disclosure details transmission systems for electrified vehicles. Exemplary transmission systems may include a crankshaft integrated starter-generator. The crankshaft integrated starter-generator may include an electric machine and an integrated rotor carrier/input shaft assembly. The integrated rotor carrier/input shaft assembly is configured to support the electric machine and provide an interface for mounting the crankshaft integrated starter-generator relative to a torque converter. The torque converter may be mounted to a flange of the integrated rotor carrier/input shaft assembly that is inside the diameter of a rotor of the electric machine.

Abstract: A pump is provided with a pump housing defining a volute chamber positioned between a central inlet and an impeller face, with the housing defining a recess intersecting the face and surrounding an aperture, and the housing defining sequentially first and second ramps, a wall section, and a protrusion extending into the recess. An impeller is positioned within the chamber adjacent to the face, with the impeller connected to a drive shaft extending through the aperture. A method is provided for cooling a drive shaft sealing member by controlling fluid flow through the pump.

Abstract: This disclosure details cooling systems for cooling electric components, such as electric machines, within electrified vehicles. Exemplary cooling systems may include a spray bar positioned relative to a rear face of a stator of the electric machine. In some embodiments, the spray bar may be positioned axially between the rear face of the stator and a torque converter housing. One or more nozzles of the spray bar are configured to direct a coolant between adjacent back irons of the stator, onto end windings of the stator, or both. Actively cooling the stator allows the electric machine to operate at higher torques and speeds, thereby increasing performance.

Abstract: This disclosure details transmission systems for electrified vehicles. Exemplary transmission systems may include a crankshaft integrated starter-generator. The crankshaft integrated starter-generator may include an electric machine and an integrated rotor carrier/input shaft assembly. The integrated rotor carrier/input shaft assembly is configured to support the electric machine and provide an interface for mounting the crankshaft integrated starter-generator relative to a torque converter. The torque converter may be mounted to a flange of the integrated rotor carrier/input shaft assembly that is inside the diameter of a rotor of the electric machine.

Abstract: Methods and systems are provided for a coolant pump. In one example, the coolant pump may be a dual-volute coolant pump with an impeller driving circulation of coolant through the pump and a seal disposed around a shaft of the impeller. A set of anti-vortex structures may be arranged within an inner chamber of the pump, the structures generating a pressure differential in the inner chamber that drives a cross-flow of coolant, thereby convectively cooling the seal.

Abstract: A micro flushing toilet to use 0.0625 GPF (gallons per flush) and flush automatically as needed when the solid human waste is accumulated within the toilet and will break the waste up as the waste travels down the sewer pipe reducing water used to move the human waste to the sewer or septic tank.

Abstract: This disclosure details cooling systems for cooling electric components, such as electric machines, within electrified vehicles. Exemplary cooling systems may include a spray bar positioned relative to a rear face of a stator of the electric machine. In some embodiments, the spray bar may be positioned axially between the rear face of the stator and a torque converter housing. One or more nozzles of the spray bar are configured to direct a coolant between adjacent back irons of the stator, onto end windings of the stator, or both. Actively cooling the stator allows the electric machine to operate at higher torques and speeds, thereby increasing performance.

Abstract: The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A pump is provided with a pump housing defining a volute chamber positioned between a central inlet and an impeller face, with the housing defining a recess intersecting the face and surrounding an aperture, and the housing defining sequentially first and second ramps, a wall section, and a protrusion extending into the recess. An impeller is positioned within the chamber adjacent to the face, with the impeller connected to a drive shaft extending through the aperture. A method is provided for cooling a drive shaft sealing member by controlling fluid flow through the pump.

Abstract: A transmission is provided. The transmission may include a planetary gearset. The transmission may also include a thrust hub that may be fixed to the planetary gearset and engaged with a thrust bearing. A clutch hub may be connected with and spaced away from the thrust hub such that the thrust and clutch hubs are not in contact with each other to reduce vibration transfer between the thrust and clutch hubs.

Abstract: A transmission is provided. The transmission may include a planetary gearset. The transmission may also include a thrust hub that may be fixed to the planetary gearset and engaged with a thrust bearing. A clutch hub may be connected with and spaced away from the thrust hub such that the thrust and clutch hubs are not in contact with each other to reduce vibration transfer between the thrust and clutch hubs.

Abstract: A fixed content server stores electronic content for delivery to a nomadic server on a vehicle. A schedule for arrival and departure of the vehicle transporting the nomadic server at a destination location is obtained, and a destination content server is identified. An electronic package is generated to contain an identifier for the vehicle and an identifier for the destination content server. Delivery of the electronic package to the destination content server at the destination location is initiated based on the schedule for arrival of the vehicle transporting the nomadic server to the destination location so delivery of the electronic package is initiated while the vehicle is traveling to the destination location. A time is determined to upload the electronic package from the destination content server to the nomadic server of the vehicle. Quality of service that a network uses to deliver the electronic package is provisioned based thereon.

Abstract: A vehicle fluid line for transporting high and low pressure fluids of an engine includes a rigid pipe having opposing ends configured to fixedly couple with the engine. An adjustable joint divides a length of the rigid tube into first and second segments. The adjustable joint has a cylindrical housing coupled with the first segment and having an inner diameter. A stop feature protrudes from an outer diameter of the second segment and interfaces with the cylindrical housing to prevent disengagement of the second segment from the housing. An elastomeric grommet is seated between the inner and outer diameters and is configured to maintain a fluid seal that allows the second segment to rotate axially, pivot radially, and slide longitudinally within the cylindrical housing.