Abstract: The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogs, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.

Abstract: A polymer composition that comprises an aromatic polyester, a laser activatable additive, and a mineral filler is provided. The mineral filler has a median size of about 35 micrometers or less and the laser activatable additive has a mean size of about 1000 nanometers or less.

Abstract: A clamping body for an electrical conductor includes a clamping body pocket. The clamping body pocket forms a receiving space for receiving the electrical conductor. The clamping body pocket is formed from a copper zinc alloy that has a lead content of less than 0.1 percent by weight, a tensile strength that is at least 640 Newtons per square millimeter, and an elongation A10 at rupture that is at least 5 percent. The clamping body also includes a threaded bore for receiving a screw, the threaded bore being formed in a side wall of the clamping body pocket.

Abstract: A flap device for an internal combustion engine or an electric vehicle includes a flap body comprising a receiving opening, a duct housing configured to rotate arranged in the flap body, an actuator, a first bearing, a stub shaft arranged to project from the actuator through the duct housing to the flap body, a slide bearing arranged in the receiving opening of the flap body, and an axial pin arranged so as to be fixed in the duct housing on a side of the flap body opposite to the stub shaft. The stub shaft is supported in the duct housing via the first bearing. The axial pin supports the flap body via the slide bearing and projects into the receiving opening.

Abstract: The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.

Abstract: A polymer composition formed from a polyarylene sulfide matrix that constitutes a majority of the polymer content of the composition is provided. Although polyarylene sulfides are not typically capable of laser activation, particularly at such a high content of the polymer composition, the present inventor has nevertheless discovered that the resulting composition can still be readily activated with one or more conductive elements using a laser direct structuring process. This is accomplished, in part, by dispersing a combination of a condensation polymer and laser activatable additive within the polyarylene sulfide matrix.

Abstract: A clamping body for an electrical conductor includes a clamping body pocket. The clamping body pocket forms a receiving space for receiving the electrical conductor. The clamping body pocket is formed from a copper zinc alloy that has a lead content of less than 0.1 percent by weight, a tensile strength that is at least 640 Newtons per square millimeter, and an elongation A10 at rupture that is at least 5 percent. The clamping body also includes a threaded bore for receiving a screw, the threaded bore being formed in a side wall of the clamping body pocket.

Abstract: The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

Abstract: An RFID transponder antenna has a carrier substrate and an auxiliary substrate. The carrier substrate is provided with a contact point for a first connection to an integrated circuit, and a first conductor path including at least two coil turns. A first end of the path forms a contact terminal for a second connection to the integrated circuit. The other end forms a connection point for an electrical connection to a second conductor path. The second path on the auxiliary substrate forms a bridge over the coil turns. The second conductor path has one end connected to the contact point, and another end connected to the connection point providing a permanent connection between the auxiliary substrate and/or the first conductor path, and the carrier substrate and/or second conductor path; the permanent connection being formed at least at one point lying between both ends of the auxiliary substrate.

Abstract: A clamping body for an electric conductor, comprising a clamping body pocket that forms a receiving space for receiving the electric conductor. A threaded bore is formed in a lateral wall of the clamping body pocket in order to receive a screw. The aim of the invention is to devise a solution in which the clamping body substantially has the properties of a clamping body that is made of art alloy containing brass and simultaneously complies with the EU guidelines and regulations prohibiting certain materials. This is achieved in that the clamping body pocket is formed from an alloy containing aluminium, said alloy having a tensile strength of 380 N/mm2 to 480 N/mm2.

Abstract: The present invention relates to bicyclic labdane diterpenes for use in the treatment of a disease associated with activation of transient receptor potential cation channel 6 (TRPC6), preferably a pulmonary or a renal disease. In one aspect the invention relates to the use of a bicyclic labdane diterpene for blocking calcium transport via TRPC6. Another aspect of the invention is a bicyclic labdane diterpene according to formula (1) for use as a medicament wherein R1 is selected from hydrogen and C1 to C4 acyl, wherein the bicyclic labdane diterpene optionally comprises at least one double bond between the carbon atoms at positions 1 and 2, 2 and 3, 5 and 6, 6 and 7 and/or 14 and 15, wherein the carbon atoms at positions 1, 2, 3, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 are connected to hydrogen atoms or comprise at least one substitution.

Abstract: An actuating apparatus includes a housing, an actuating unit, a receiver element, and a transmitter element. The actuating unit comprises a first end with a circular arc-shaped contour whose circular arc central axis is configured to act as a first pivot axis. The actuating unit is configured to be moved via an actuator and to undertake a translational main movement and a pivoting movement. The translational main movement is superimposed by the pivoting movement. The receiver element is fixedly arranged in the housing. The transmitter element comprises a magnetic field. The transmitter element is configured to be translationally movable, to be biased so as to bear against the first end of the actuating unit, and to cooperate with the receiver element.

Abstract: The invention relates to an assembly for a brake actuator which is provided, for example, for an electromechanically operated parking brake. The assembly comprises a drive device and a gear device for generating and transmitting a torque to a brake device, a carrier element having a first mounting device to which the drive device and the gear device are mechanically secured, and a housing having a housing lower portion which has a second mounting device, on which the carrier element together with the drive device and gear device is arranged in a self-supporting manner by means of the first mounting device.

Abstract: The present invention relates to novel compounds of formulae (I) and (II) which are useful in the prevention, treatment and diagnosis, in vivo diagnosis of diseases or disorders related to S1P receptors, in particular, in diseases which are connected to the regulatory function of sphingosine-1-phosphate (S1P) and its analogues, such as inflammation, pain, autoimmune diseases and cardiovascular diseases.

Abstract: Frameworks for providing modular computer program code and automated configuration of server-based gaming environments are disclosed. One or more “pluggable” modular gaming modifier can be provided for the modular computer program code without requiring the replacement of the entire computer program code for the game. Typically, the pluggable” modular gaming modifier can be added to or can replace one or more gaming modules or sub-modules, thereby requiring less time and effort for effectively modifying game presentation. In addition, configuration data can be generated and stored as configurations templates which can be used to configure one or more gaming machines in an automated manner. The configuration templates can be generated based on gaming modules and/or sub-modules provided for modular computer program code.

Abstract: A high-voltage connector component for a high-voltage cable comprises an insulator made of a polymer material which surrounds a cable end portion of the high-voltage cable, wherein the insulator is received in a housing and is made of an elastomer material, wherein the elastomer material is filled, cast or injected into the housing in order to form the insulator. The connector component is designed such that upon connection to a corresponding connector component a basically closed pressure chamber is formed between the housing, the corresponding connector component and the cable end portion, wherein the pressure chamber is basically provided for being completely occupied by the insulator.

Abstract: The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical use and to medicaments comprising them.

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.