Abstract: Peptide nucleic acids, compositions containing the peptide nucleic acids, and methods utilizing the peptide nucleic acids are described. The peptide nucleic acids, compositions, and methods are designed to inhibit global regulatory bacterial genes and useful for preventing biofilm formation on biotic and abiotic surfaces. The PNAs are designed to account for nuanced interspecies variations in these regulatory genes, thus allowing for simultaneous inhibition of multiple bacterial species as well as polymicrobial biofilms. The disclosure outlines the composition of wide range PNAs (wrPNAs) and applications for delivery.

Abstract: An optical element held in a holder has a first optical surface which has no rotational symmetry with regard to its imaging axis. The holder has at least one reference element, which defines a position and/or orientation of the holder in a predefined coordinate system which compensates for a difference between an actual pose of the first optical surface and a target pose of the first optical surface in the holder at least in one degree of freedom. The reference element defines at least one specific azimuthal position of the holder. Also provided is a method for adjusting the holder of an optical element that has at least a first optical surface, which has no rotational symmetry with regard to its imaging axis, to a difference between an actual pose of the first optical surface and a target pose of the first optical surface in the holder.

Abstract: A method for monitoring a machine state of a machine system, in particular a wind power plant, may include the steps of providing a time series of measured natural vibration spectra of the machine system, detecting a deformation parameter in at least one monitoring time interval, wherein the deformation parameter is characteristic of a deviation of the measured natural vibration spectra from a reference natural vibration spectrum of at least one reference machine system, detecting a noise parameter at the at least one monitoring time interval, wherein the noise parameter is characteristic of a noise of the measured natural vibration spectra, and determining the machine state from the deformation parameter and the noise parameter. A monitoring apparatus for monitoring a machine state of a machine system, in particular a wind power plant, is also described.

Abstract: Methods and systems for organizing and conducting a computer-implemented simulation to support an exercise are disclosed. The method includes a processor receiving, via a first GUI prior to the simulation, configuration data representing at least: (a) organizational nodes, (b) organizational pathways, (c) interorganizational relationships, and (d) one or more first events that change the interorganizational relationships.

Abstract: An X-ray laser apparatus (100) for generating X-rays (1) comprises an excitation laser device (10) arranged to generate re) driving laser pulses (2), and a converter material source device (20) arranged to provide a droplet-shaped converter material, which is capable of generating X-rays (1) by non-linear frequency conversion in response to an irradiation with the driving laser pulses (2), wherein the excitation laser device (10) is arranged for a focused irradiation of the droplet-shaped converter material and the converter material source device (20) is configured to provide superfluid Helium droplets (3), which provide the converter material. Furthermore, a method for generating X-rays (1) is described, wherein superfluid Helium droplets (3) are utilized as a converter material.

Abstract: Methods and systems for organizing and conducting a computer-implemented simulation to support an exercise are disclosed. The method includes a processor receiving, via a first GUI prior to the simulation, configuration data representing at least: (a) organizational nodes, (b) organizational pathways, (c) interorganizational relationships, and (d) one or more first events that change the interorganizational relationships.

Abstract: Computer-implemented methods of enabling an on-the-fly generation of at least one user-defined montage from EEG electrodes positioned in a patient's brain, on the patient's brain and/or on the patient's scalp. The methods includes generating a graphical interface to display a view of the patient's brain and/or scalp overlaid with the EEG electrodes, each of which is uniquely identified with reference to its position in the patient's brain, on the patient's brain and/or on the patient's scalp, displaying a tool within the graphical interface for selecting at least one electrode from the displayed EEG electrodes, indicating a reference electrode corresponding to the selected electrode, accessing EEG signals corresponding to the electrode and the reference electrode, and generating another graphical interface to display an EEG trace indicative of a comparison of EEG signals of the electrode and the reference electrode.

Abstract: Computer-implemented methods of enabling an on-the-fly generation of at least one user-defined montage from EEG electrodes positioned in a patient's brain, on the patient's brain and/or on the patient's scalp. The methods includes generating a graphical interface to display a view of the patient's brain and/or scalp overlaid with the EEG electrodes, each of which is uniquely identified with reference to its position in the patient's brain, on the patient's brain and/or on the patient's scalp, displaying a tool within the graphical interface for selecting at least one electrode from the displayed EEG electrodes, indicating a reference electrode corresponding to the selected electrode, accessing EEG signals corresponding to the electrode and the reference electrode, and generating another graphical interface to display an EEG trace indicative of a comparison of EEG signals of the electrode and the reference electrode.

Abstract: An apparatus and a method for controlling the output of driver information to a driver of a vehicle, with the objective of entertaining the driver and/or the passengers of the vehicle and/or increasing the driver attentiveness of the driver. A database of points of interest or objects of general interest, a database of topographic information, a device for determining the whereabouts of the vehicle, and an evaluation device to which these information items are delivered, are provided. The evaluation device ascertains, from the current whereabouts of the vehicle and from the topographic information, which points of interest or objects of general interest are present in the driver's field of view, and outputs via an output device the driver information regarding the point of interest or the object of general interest which has been ascertained by the evaluation device to be located in the driver's field of view.

Abstract: An optical element held in a holder has a first optical surface which has no rotational symmetry with regard to its imaging axis. The holder has at least one reference element, which defines a position and/or orientation of the holder in a predefined coordinate system which compensates for a difference between an actual pose of the first optical surface and a target pose of the first optical surface in the holder at least in one degree of freedom. The reference element defines at least one specific azimuthal position of the holder. Also provided is a method for adjusting the holder of an optical element that has at least a first optical surface, which has no rotational symmetry with regard to its imaging axis, to a difference between an actual pose of the first optical surface and a target pose of the first optical surface in the holder.

Abstract: An apparatus and a method for controlling the output of driver information to a driver of a vehicle, with the objective of entertaining the driver and/or the passengers of the vehicle and/or increasing the driver attentiveness of the driver. A database of points of interest or objects of general interest, a database of topographic information, a device for determining the whereabouts of the vehicle, and an evaluation device to which these information items are delivered, are provided. The evaluation device ascertains, from the current whereabouts of the vehicle and from the topographic information, which points of interest or objects of general interest are present in the driver's field of view, and outputs via an output device the driver information regarding the point of interest or the object of general interest which has been ascertained by the evaluation device to be located in the driver's field of view.

Abstract: An actuator for adjusting an element to be moved in a beam path of an optical arrangement contains the element to be moved, a carrier and at least one SM element, the SM element being connected to the element to be moved and designed such that it is supported on the carrier, so that when the dimension of the SM element changes, a directed force effect is produced between the element to be moved and the carrier.

Abstract: A method for operating a vehicle having a driver assistance system intervening in a transverse dynamics of the vehicle, comprising the steps: detecting a driver intervention in a driving behavior of the vehicle due to an intervention of at least one actuator triggered by the driver assistance system; interpreting the driver intervention as an override of the intervention of the actuator; and reducing in a defined manner the intervention of the actuator as a function of the interpretation of the driver intervention in such a way that a driving task is returned to the driver in a controlled and defined manner.

Abstract: Computer-implemented methods of enabling an on-the-fly generation of at least one user-defined montage from EEG electrodes positioned in a patient's brain, on the patient's brain and/or on the patient's scalp. The methods includes generating a graphical interface to display a view of the patient's brain and/or scalp overlaid with the EEG electrodes, each of which is uniquely identified with reference to its position in the patient's brain, on the patient's brain and/or on the patient's scalp, displaying a tool within the graphical interface for selecting at least one electrode from the displayed EEG electrodes, indicating a reference electrode corresponding to the selected electrode, accessing EEG signals corresponding to the electrode and the reference electrode, and generating another graphical interface to display an EEG trace indicative of a comparison of EEG signals of the electrode and the reference electrode.

Abstract: A method and device for the optical scanning of a chromatographic sample (3), where a sample plate (2) holding the sample (3) is illuminated with light from a first illumination device (13) and the light emitted by the sample plate (2) is detected by an optical detector device (15) which detects in cell form or area form, a second illumination device (14) is preferably firstly activated in a preparation step. The sample plate (2) is displaced in a first displacement direction relative to the detector device (15), illuminated by the first illumination device (13) and a first measurement image is recorded. The sample plate (2) is displaced in a second displacement direction relative to the detector device (15), illuminated by the second illumination device (14), and a second measurement image is recorded.

Abstract: The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the ?-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the ?-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: An annular clamping nut which is provided for being placed onto the end of a tie bar, in order to brace the latter, and which has in addition to a central recess for receiving the tie bar parallel to a longitudinal direction passages at uniform radial spacings in the ring circumferential direction which are directed parallel to the longitudinal direction of the central recess and are provided for receiving clamping screws. An external thread is provided on the outer surface of the clamping nut, which outer surface is arranged on a side which lies substantially opposite the wall of the central recess, which external thread runs substantially in the ring circumferential direction of the outer surface.

Abstract: An actuator for adjusting an element to be moved in a beam path of an optical arrangement contains the element to be moved, a carrier and at least one SM element, the SM element being connected to the element to be moved and designed such that it is supported on the carrier, so that when the dimension of the SM element changes, a directed force effect is produced between the element to be moved and the carrier.