Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the ?-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: A plumbing system includes a tub having a drain fixture lodged within a floor drain opening. The drain fixture comprises a body member beneath the floor and a drain cap member inserted into an exposed open inlet of the body member. The body member has a passageway extending between the open inlet and a downstream open outlet in communication with a sewer. A pipe connected to the body member between the inlet and outlet has one end in communication with the passageway and another end in communication with an overflow opening in the tub above the drain opening to vent the passageway. The drain cap member moves between a first position allowing liquid to flow through the passageway and a second position preventing the flow of liquid through the passageway.

Abstract: An annular clamping nut which is provided for being placed onto the end of a tie bar, in order to brace the latter, and which has in addition to a central recess for receiving the tie bar parallel to a longitudinal direction passages at uniform radial spacings in the ring circumferential direction which are directed parallel to the longitudinal direction of the central recess and are provided for receiving clamping screws. An external thread is provided on the outer surface of the clamping nut, which outer surface is arranged on a side which lies substantially opposite the wall of the central recess, which external thread runs substantially in the ring circumferential direction of the outer surface.

Abstract: The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

Abstract: A torque measurement system for measuring a torque acting on a rotatable shaft is provided. The torque measurement system includes a first housing portion having a first end adapted to be fixedly coupled to the rotatable shaft and a second end. The torque measurement system includes a second housing portion having a first end spaced apart from the second end of the first housing portion so as to define a gap between the first housing portion and the second housing portion. The second housing portion is adapted to be fixedly coupled to the rotatable shaft. The torque measurement system includes at least one sensor that observes at least one of the second end of the first housing portion, the first end of the second housing portion and the gap and generates sensor signals based on the observation. The sensor signals are indicative of a torque acting on the rotatable shaft.

Abstract: The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

Abstract: A method operates a railway safety system having at least one trackside device while taking into account a measured velocity value recorded when the rail vehicle drives into a switch-on section of the railway safety system. In order to minimize the closing times for a level crossing by such a method, the measured velocity value is used as the basis for checking whether a correction time for forwarding a signal from the one trackside device to an associated railway safety assembly is to be set according to the measured velocity value when the rail vehicle drives into the switch-on section. Thereafter, a set correction time is checked to determine if the set correction time should remain effective according to at least one further influencing variable of the rail vehicle that determines the travel time. A railway safety system for carrying out the method is also provided.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, L1 and G1 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the ?-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Abstract: Olefin metathesis between an acrylate monomer and a polyene comprising molecule or polymer is employed as a method of cross-metathesizing or depolymerizing the molecule. The metathesis reaction forms a telechelic acrylate molecule that is a monomer, oligomer or polymer. The telechelic acrylate molecule can be employed as a monomer for condensation polymerization.

Abstract: The invention concerns a tool for machining of materials, specifically a grinding tool, which has a substantially rotationally symmetrical shape with respect to a rotation axis (R), the tool comprising an outer shell centred about the rotation axis and defining an internal space therein, wherein at least a part of a surface of the outer shell is provided with an abrasive coating or component, wherein the outer shell encases an internal skeleton structure in the internal space, the internal skeleton being integral with the outer shell and defining void volumes in the internal space thereby establishing material and void volumes of the internal space, and wherein the material to void ratio M/V is distributed substantially identically along each radius (r) centred around the rotation axis (R) and its corresponding symmetrical radius (r?). The invention also concerns a method for producing such tool.

Abstract: A laser pulse shaper device includes shaper unit including first dispersive element for spatially separating spectral components of laser pulses, second dispersive element for parallelizing and deflecting spectral components into Fourier plane of dispersive elements, and mirror for back-reflecting of laser pulses via dispersive elements, and light modulator in Fourier plane of dispersive elements, which is capable of modulating spectral components of laser pulses, wherein beam path of shaper unit includes forward beam path from first dispersive element via second dispersive element to mirror and return beam path from mirror via second dispersive element to first dispersive element, and focusing device is arranged at input side of forward beam path before first dispersive element for focusing spatially separated spectral components of laser pulses to Fourier plane of dispersive elements. Furthermore, a method for stretching or compressing laser pulses is described.

Abstract: The present invention relates to a thin-layer chromatography plate at least consisting of a support and a sorbent layer, where the sorbent layer comprises at least one siloxane oligomer, to a process for the production thereof, and to a method for carrying out a thin-layer chromatographic separation using said thin-layer chromatography plate.

Abstract: A circuit arrangement for transferring energy includes an energy source, a control device and an energy distribution network. The energy distribution network has a base element and at least one load element. The base element includes a first intermediate circuit energy storage element which can be electrically connected to or disconnected from the energy source via two first controllable switching elements by way of the control device to form a first energy circuit. The at least one load element includes an energy consumer which can be electrically connected to or disconnected from the connections of the first intermediate circuit energy storage element via two second controllable switching elements by way of the control device to form a second energy circuit.

Abstract: The invention relates to a method for carrying out thin-layer chromatography in which a liquid sample is applied to a separating layer (14), in which a mobile phase is subsequently applied to the separating layer (14) and brought into contact with the sample, and in which, after a development phase, a thin-layer chromatogram is produced, the liquid sample is taken up from a sample storage container (11, 12, 13) with the aid of an autopipette (4) using a new pipette tip (8, 9) for each sample application operation and applied to the separating layer (14). The invention further relates to a device (5) which is suitable for carrying out the method.

Abstract: A plumbing system includes a tub having a drain fixture lodged within a floor drain opening. The drain fixture comprises a body member beneath the floor and a drain cap member inserted into an exposed open inlet of the body member. The body member has a passageway extending between the open inlet and a downstream open outlet in communication with a sewer. A pipe connected to the body member between the inlet and outlet has one end in communication with the passageway and another end in communication with an overflow opening in the tub above the drain opening to vent the passageway. The drain cap member moves between a first position allowing liquid to flow through the passageway and a second position preventing the flow of liquid through the passageway.

Abstract: Method and apparatus for the electrodeposition of a contact metal layer on contact areas of semiconductor components in a wafer assemblage. The method comprises: a) providing a wafer having components having at least one pn junction; b) arranging a non-conductive homogenizing device with respect to the first surfaces of the components, and an electrical contact device at a second surface of the wafer; c) introducing the wafer into an electroplating bath having an electrode, wherein the surface thereof consists at least partly of a first contact metal, and wherein the first surface of the components is in contact with the electroplating bath; d) applying a voltage to the electrode and to the contact device, as a result of which current flows between the electrode and the contact device, through the electroplating bath and the component and contact metal is thus deposited at the first contact areas of the components.

Abstract: A laser pulse shaper device includes shaper unit including first dispersive element for spatially separating spectral components of laser pulses, second dispersive element for parallelizing and deflecting spectral components into Fourier plane of dispersive elements, and mirror for back-reflecting of laser pulses via dispersive elements, and light modulator in Fourier plane of dispersive elements, which is capable of modulating spectral components of laser pulses, wherein beam path of shaper unit includes forward beam path from first dispersive element via second dispersive element to mirror and return beam path from mirror via second dispersive element to first dispersive element, and focusing device is arranged at input side of forward beam path before first dispersive element for focusing spatially separated spectral components of laser pulses to Fourier plane of dispersive elements. Furthermore, a method for stretching or compressing laser pulses is described.