Patents by Inventor Michael Schwarm

Michael Schwarm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10017712
    Abstract: The present disclosure relates generally to a process for manufacturing products enriched in the content of at least one vitamin E component, preferably tocotrienol, using solvent extraction and membrane filtration.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: July 10, 2018
    Assignee: Evonik Degussa GmbH
    Inventors: Andrew Boam, Yuri Bouwhuis, Velichka Yordanova Koleva, Maria Ines Fontes Rocha, Michael Schwarm
  • Publication number: 20170367394
    Abstract: A processes for increasing the stability of a composition containing polyunsaturated an omega-6 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-6 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting a resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from the polyunsaturated omega-6 fatty acid; the product composition exhibiting a solvent content SC selected from the following; SC<5 wt %, SC<3 wt %, SC<1 wt %, or <0.5 wt %.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 28, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM
  • Publication number: 20170360072
    Abstract: A process for increasing the stability of a composition containing a polyunsaturated omega-3 fatty acid against oxidation proceeds by (i) providing a starting composition containing at least one polyunsaturated omega-3 fatty acid component; (ii) providing a lysine composition; (iii) admixing an aqueous, an aqueous-alcoholic or an alcoholic solution of starting composition and lysine composition, and subjecting resulting admixture to spray drying conditions subsequently, thus forming a solid product composition containing at least one salt of a cation derived from lysine with an anion derived from a polyunsaturated omega-3 fatty acid; the product composition exhibiting a solvent content SC selected from the following: SC<5 wt %, SC<3 wt %, SC<1 wt %, or SC<0.5 wt %.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 21, 2017
    Applicant: Evonik Degussa GmbH
    Inventors: Guenter KNAUP, Milan LATINOVIC, Michael SCHWARM
  • Publication number: 20170166837
    Abstract: The present disclosure relates generally to a process for manufacturing products enriched in the content of at least one vitamin E component, preferably tocotrienol, using solvent extraction and membrane filtration.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 15, 2017
    Inventors: Andrew Boam, Yuri Bouwhius, Velichka Yordanova Koleva, Maria Ines Fontes Rocha, Michael Schwarm
  • Patent number: 9194009
    Abstract: Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: November 24, 2015
    Assignee: EVONIK DEGUSSA GmbH
    Inventors: Oliver May, Stefan Buchholz, Michael Schwarm, Karlheinz Drauz, Robert J. Turner, Ian Fotheringham
  • Publication number: 20090203091
    Abstract: The present invention relates to specific Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.
    Type: Application
    Filed: January 21, 2009
    Publication date: August 13, 2009
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Oliver MAY, Stefan Buchholz, Michael Schwarm, Karlheinz Drauz, Robert J. Turner, Ian Fotheringham
  • Patent number: 7427691
    Abstract: The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: September 23, 2008
    Assignee: Degussa GmbH
    Inventors: Dieter Most, Kai Rossen, Michael Schwarm
  • Publication number: 20080064897
    Abstract: The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents.
    Type: Application
    Filed: July 6, 2005
    Publication date: March 13, 2008
    Applicant: Gegussa AG
    Inventors: Dieter Most, Kai Rossen, Michael Schwarm
  • Publication number: 20060228787
    Abstract: The present invention relates to specific E. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids.
    Type: Application
    Filed: October 15, 2003
    Publication date: October 12, 2006
    Inventors: Oliver May, Stefan Buchholz, Karlheinz Drauz, Michael Schwarm, Robert Turner, Ian Fotheringham
  • Publication number: 20050171360
    Abstract: A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2-thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.
    Type: Application
    Filed: January 30, 2003
    Publication date: August 4, 2005
    Inventors: Dietmar Reichert, Juan Almena Perea, Michael Schwarm, Karlheinz Drauz, Hans-Peter Krimmer
  • Publication number: 20040198974
    Abstract: The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is performed for industrial scale production of pure enantiomers of deemed amino acids which are useful intermediates in organic synthesis.
    Type: Application
    Filed: February 13, 2004
    Publication date: October 7, 2004
    Inventors: Kurt Guenther, Stefan Merget, Karlheinz Drauz, Hans-Peter Krimmer, Michael Schwarm
  • Patent number: 6492541
    Abstract: The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II which can be prepared from the intermediate compounds V.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: December 10, 2002
    Assignee: Degussa-Huls Aktiengesellschaft
    Inventors: Karlheinz Drauz, Günter Knaup, Michael Schwarm
  • Publication number: 20020045763
    Abstract: The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I 1
    Type: Application
    Filed: December 7, 2001
    Publication date: April 18, 2002
    Applicant: Degussa-Huls Aktiengensellschaft
    Inventors: Karlheinz Drauz, Gunter Knaup, Michael Schwarm
  • Patent number: 6333176
    Abstract: A plant peptide amidase from the flavedo of oranges is known; this can be obtained only in small quantities and is seasonal. The proposed new enzymes are microbial peptide amidases which can be obtained from micro-organisms recovered from soil samples in a “double screening” and grown. These microbial peptide amidases are particularly useful for (a) the production of peptides and N-terminal-protected amino acids, (b) racemate splitting of N-protected amino acid amides, (c) obtaining non-proteinogenous D-amino acids, and (d) obtaining new N&agr;-protected D-amino acid amides.
    Type: Grant
    Filed: August 25, 1999
    Date of Patent: December 25, 2001
    Assignee: Degussa Aktiengesellschaft
    Inventors: Ursula Stelkes-Ritter, Maria-Regina Kula, Klaudia Wyzgol, Andreas Bommarius, Michael Schwarm, Karlheinz Drauz
  • Publication number: 20010025109
    Abstract: The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I 1
    Type: Application
    Filed: May 21, 2001
    Publication date: September 27, 2001
    Applicant: Degussa-Huls Aktiengensellschaft
    Inventors: Karlheinz Drauz, Gunter Knaup, Michael Schwarm
  • Patent number: 6281364
    Abstract: The present invention relates to a process for the preparation of &ggr;-lactams of the general formula I The invention relates also to novel advantageous intermediates of the general formulae V, IV and II and their salts and their use. The compounds of the general formula I are obtained by cyclising compounds of the general formula II which can be prepared from the intermediate compounds V.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 28, 2001
    Assignee: Degussa-Huls AG
    Inventors: Karlheinz Drauz, Günter Knaup, Michael Schwarm
  • Patent number: 5985632
    Abstract: A plant peptide amidase from the flavedo of oranges is known; this can be obtained only in small quantities and is seasonal. The proposed new enzymes are microbial peptide amidases which can be obtained from micro-organisms recovered from soil samples in a "double screening" and grown. These microbial peptide amidases are particularly useful for (a) the production of peptides and N-terminal-protected amino acids, (b) racemate splitting of N-protected amino acid amides, (c) obtaining non-proteinogenous D-amino acids, and (d) obtaining new N.sub..alpha. -protected D-amino acid amides.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: November 16, 1999
    Assignee: Degussa Aktiengesellschaft
    Inventors: Ursula Stelkes-Ritter, Maria-Regina Kula, Klaudia Wyzgol, Andreas Bommarius, Michael Schwarm, Karlheinz Drauz
  • Patent number: 5874121
    Abstract: The invention concerns a method of producing L-aspartyl-D-alanine-N-(thietane-3-yl) amides of general formula I by reacting D-alanine-thietane amides of general formula II with oxazolidinone compounds of general formula III in an inert organic solvent, wherein R.sup.1 stands for H or a selectively separable protective group, R.sup.2 -R.sup.5 independently of one another, are identical or different and stand for H or linear or branched C.sub.1 -C.sub.4 -alkyl, and R.sup.6 and R.sup.7, independently of each other, are identical or different and stand for H, linear or branched C.sub.1 -C.sub.4 -alkyl, aryl or a group which activates the carbonyl group.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: February 23, 1999
    Assignee: Degussa AG
    Inventors: Karlheinz Drauz, Gunter Knaup, Stefan Retzow, Michael Schwarm, Christoph Weckbecker
  • Patent number: 5723667
    Abstract: A method of producing optically active tert-leucinol (formula I) of high enantiomeric purity ##STR1## by converting racemic (RS)-tert-leucinol into a diastereomeric salt pair by reaction with an optically active acid, removing the salt pair from solution by fractionated crystallization and separating therefrom the optically active acid to release the optically active tert-leucinol from the salt. The optically active acid used is an N-acylated tert-leucine of general formula VIII: ##STR2## in which R can be hydrogen or an alkyl-, arylalkyl- or aryl group with up to 20 C atoms and * signifies a chirality center.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: March 3, 1998
    Assignee: Degussa Aktiengesellschaft
    Inventors: Karlheinz Drauz, Wilfried Jahn, Michael Schwarm
  • Patent number: 5672753
    Abstract: .alpha.-oximino carboxylic acids or their esters are reduced with an alkali boron hydride and hydrogen chloride or sulfuric acid to yield racemic amino alcohols (e.g. (RS)-tert-leucinol).
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: September 30, 1997
    Assignee: Degussa Aktiengesellschaft
    Inventors: Karlheinz Drauz, Wilfried Jahn, Michael Schwarm