Abstract: An implant system comprising at least one staple, a cage and a coupling mechanism is disclosed. The implant system is secured to the bone by moving the staple with the coupling mechanism whereby the staple frictionally and mechanically engages or embeds itself in the bone. In some embodiments, the coupling mechanism includes a keyway mechanism to constrain the movement of the staple. In some embodiments the staple comprises two staples. The implant system may be configured for use as an interbody or intrabody implant system. In some embodiments, the cage comprises multiple cage sections. Some embodiments of the implant system are configured to be positioned from one of a posterior approach trajectory, a posterior lateral approach trajectory, or a posterior oblique approach trajectory. Some embodiments of the implant system are configured for use in a posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion (TLIF) procedure.

Abstract: An implant system comprising one or more staple and a cage is disclosed. The implant system is secured to a bone by moving the staple whereby tines of the staple frictionally and mechanically engage or embed themselves in the bone sidewalls. In some embodiments, the staple comprises a first staple and a second staple. In some embodiments, the staples are positioned transverse to an approach trajectory of positioning of the implant system. The implant system may be configured for use as an interbody or intrabody implant system. The implant system may further comprise tools for positioning the implant system. Some embodiments of the implant device are configured to be positioned from an anterior trajectory, an anterior lateral approach trajectory, or an anterior oblique approach trajectory relative to the bone. Some embodiments of the implant device are configured to be used in an anterior lumbar interbody fusion (ALIF) procedure.

Abstract: Systems and methods are provided for robotically assisted disc prosthesis selection and implantation. The system includes a 3D modeling system for creating a 3D model of first and second vertebra adjacent the intended surgical site and identifying and storing data for the positions of the first and second vertebrae. A computing system for stores and processes the 3D model and the position data. A robot connected to the computing system attaches to a plurality of instruments including sizing templates, trials, cutters or placement instruments for intervertebral disc prostheses. An interface on the computing system allows the surgeon to sequentially deliver the plurality of instruments with the robot to a registration position to improve the speed and accuracy of the surgical procedure.

Abstract: Systems and methods for robotically preparing a disc space are provided for implantation of an intervertebral prosthetic disc. The system includes three-dimensional modeling to identify positions of vertebrae adjacent a surgical site and a disc selection interface in a computing system to allow the surgeon to select an intervertebral disc prosthesis for implantation. A bone cutting interface allows the surgeon to determine a bone cutting pattern tailored to both the three-dimensional positions of the vertebrae and the selected intervertebral disc. A robot controls a cutting device or guides a cutting device to cut the vertebral bone in the bone cutting pattern.

Abstract: Systems and methods are provided for robotically assisted disc prosthesis selection and implantation. The system includes a 3D modeling system for creating a 3D model of first and second vertebra adjacent the intended surgical site and identifying and storing data for the positions of the first and second vertebrae. A computing system for stores and processes the 3D model and the position data. A robot connected to the computing system attaches to a plurality of instruments including sizing templates, trials, cutters or placement instruments for intervertebral disc prostheses. An interface on the computing system allows the surgeon to sequentially deliver the plurality of instruments with the robot to a registration position to improve the speed and accuracy of the surgical procedure.

Abstract: Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cytokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 compositions are useful for prophylaxis and treatment of inflammatory diseases and related methods. In certain embodiments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syndrome, type 2 diabetes, fat liver, inflammatory bowel disease, chronic pancreatitis, asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), osteoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative diseases (ALS, Parkinson, Alzheimer's, Huntington disease), depression, schizophrenia, gout, asbestosis and silicosis.

Abstract: Systems and methods for robotically preparing a disc space are provided for implantation of an intervertebral prosthetic disc. The system includes three-dimensional modeling to identify positions of vertebrae adjacent a surgical site and a disc selection interface in a computing system to allow the surgeon to select an intervertebral disc prosthesis for implantation. A bone cutting interface allows the surgeon to determine a bone cutting pattern tailored to both the three-dimensional positions of the vertebrae and the selected intervertebral disc. A robot controls a cutting device or guides a cutting device to cut the vertebral bone in the bone cutting pattern.

Abstract: The insertion instrument 10 for inserting a modular intervertebral fusion device or components thereof into an intervertebral space comprises at least one superior arm 16, 18 mounted on a superior support 12 such that the at least one superior arm extends from the superior support. The insertion instrument further comprises at least one inferior arm 20, 22 mounted on an inferior support 14 such that the at least one inferior arm extends from the inferior support.

Abstract: An elevator tool for preparing a surgical site for an implant device is disclosed. The elevator tool comprises a distal paddle coupled to a paddle handle assembly and a positioning grip. The paddle handle assembly influences movement of the distal paddle and the positioning grip influences position of the distal paddle. The paddle handle assembly is coupled to the distal paddle with an inner shaft extending through the receiving grip whereby the distal paddle can be placed on the contralateral side of a bone and can be moved by the paddle handle assembly oriented on the ipsilateral side of the bone. The distal paddle comprises an elongated member having at least one arm configured to be rotated at least about 90 degrees by the paddle handle assembly to remove obstructions on the contralateral side of the vertebral body from a position oriented on the ipsilateral side of the vertebral body.

Abstract: An implant system comprising a staple and a cage is disclosed. The implant system is secured to the bone by moving the staple rotationally and longitudinally whereby tines of the staple and opposing tines frictionally and mechanically engage or embed themselves in the bone side walls. For vertebral applications, the cage defines an upper surface plane, a lower surface plane and a cage surface angle between these two planes whereby the cage surface angle may alter an endplate surface plane of one or more vertebral body when the cage is implanted in a vertebral body. Implant systems may be configured for use as an interbody or intrabody implant system. The implant system may also be configured for use in arthrodesis procedures with other joints within the body. The implant system may further comprise an anchor frame or plate to further secure the cage and staple to the anatomy.

Abstract: The insertion instrument (10) for inserting a modular intervertebral fusion device or components thereof into an inter-vertebral space comprises at least one superior (arm 16), (18) mounted on a superior support (12) such that the at least one superior arm extends from the superior support. The insertion instrument further comprises at least one inferior arm (20), (22) mounted on an inferior support (14) such that the at least one inferior arm extends from the inferior support.

Abstract: Systems and methods for tibial plateau leveling osteotomy (TPLO) are disclosed. According to some embodiments, an osteotomy method may include cutting a tibia with an arcuate cut to separate a tibial plateau of the tibia from a tibial base of the tibia, rotating the tibial plateau relative to the tibial base from a first orientation to a second orientation, and, with the tibial plateau in the second orientation relative to the tibial base, securing an implant to the tibia to secure the tibial plateau to the tibial base. Securing the implant to the tibia may include embedding a first leg of the implant into the tibial base, and embedding a second leg of the implant into the tibial plateau such that the first and second legs apply compression urging the tibial plateau toward the tibial base.

Abstract: An assembly for determining height and angle of an intervertebral device to be implanted in an intervertebral space. The assembly comprises a sizing instrument (12) comprising a support (18) attached to first and second arms (20), (22) which extend in generally a same direction from the support. The assembly also comprises superior and inferior endplates (14), (16) of the intervertebral device to be implanted. One of the superior and inferior endplates (14), (16) engages with a distal end of the first arm (20) and the other of the superior and inferior endplates (14), (16) engages with a distal end of the second arm (22), the superior and inferior endplates opposing each other when they are engaged with their respective arms.

Abstract: An implant system comprising a staple and a cage is disclosed. The implant system is secured to the bone by moving the staple rotationally and longitudinally whereby tines of the staple and opposing tines frictionally and mechanically engage or embed themselves in the bone side walls. For vertebral applications, the cage defines an upper surface plane, a lower surface plane and a cage surface angle between these two planes whereby the cage surface angle may alter an endplate surface plane of one or more vertebral body when the cage is implanted in a vertebral body. Implant systems may be configured for use as an interbody or intrabody implant system. The implant system may also be configured for use in arthrodesis procedures with other joints within the body. The implant system may further comprise an anchor frame or plate to further secure the cage and staple to the anatomy.

Abstract: An implant system comprising a staple and a cage is disclosed. The implant system is secured to the bone by moving the staple rotationally and longitudinally whereby tines of the staple and opposing tines frictionally and mechanically engage or embed themselves in the bone side walls. For vertebral applications, the cage defines an upper surface plane, a lower surface plane and a cage surface angle between these two planes whereby the cage surface angle may alter an endplate surface plane of one or more vertebral body when the cage is implanted in a vertebral body. Implant systems may be configured for use as an interbody or intrabody implant system. The implant system may also be configured for use in arthrodesis procedures with other joints within the body. The implant system may further comprise an anchor frame or plate to further secure the cage and staple to the anatomy.

Abstract: The present invention concerns generally with a device for reeling in fishing tackle in a more efficient and convenient way by increasing the rotational speed of reeling in via the proposed pull lever mechanism.

Abstract: Provided herein is a scaffold for growing bone, comprising a randomized porosity pattern typical of native trabecular bone. The present disclosure also provides a medical device comprising a scaffold disclosed herein.

Abstract: Systems and methods are provided for robotically assisted disc prosthesis selection and implantation. The system includes a 3D modeling system for creating a 3D model of first and second vertebra adjacent the intended surgical site and identifying and storing data for the positions of the first and second vertebrae. A computing system for stores and processes the 3D model and the position data. A robot connected to the computing system attaches to a plurality of instruments including sizing templates, trials, cutters or placement instruments for intervertebral disc prostheses. An interface on the computing system allows the surgeon to sequentially deliver the plurality of instruments with the robot to a registration position to improve the speed and accuracy of the surgical procedure.

Abstract: Systems and methods for robotically distracting a disc space are provided for implantation of an intervertebral prosthetic disc. The system includes a 3D modeling system for creating a 3D model of first and second vertebra adjacent the disc space and identifying positions of the first and second vertebrae and generating and storing position data for the positions of the first and second vertebrae. A robotic distractor determines a size of an intervertebral disc prosthesis to be implanted between the first and second vertebrae and precisely opens the disc space just large enough to receive a selected intervertebral disc. A computing system stores and processes the 3D model and the positions of the first and second vertebrae before and after distraction.

Abstract: Systems, devices, and methods for linking orders to develop a consolidated audit trail (CAT) are configured to receive event data for one or more orders based on one or more order characteristics; determine linkages between the one or more orders based on parent relationships of the one or more orders; verify the linkages between the one or more orders based on the event data; and determine order lifecycles based on the linkages between the one or more orders.