Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: An ironing system includes a ram, a sensor system, and a punch nose. The ram includes a ram body and a ram nose, and the ram includes an inner surface that defines an inner chamber. The punch nose is connected to the ram nose via the sensor, and the sensor is configured to detect a force on the punch nose during an ironing process. An adaptor may be coupled to the inner surface of the ram, and the adaptor may support the sensor on the ram body.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A can redraw and ironing system includes a ram, a punch, and a sensor system. The ram includes a ram body and a ram nose. The punch is supported on the ram nose and is configured to engage a metal blank during an ironing process. The sensor system includes a first sensor that detects a total force on the ram and a second sensor that detects a force on the ram nose.

Abstract: A method and system for micro-betting. One or more micro-bets can be electronically placed with respect to one or more micro-events associated with an event during a round of micro-betting. One or more wages with respect to the micro-bet(s) can be managed and controlled during the round of micro-betting. The wager(s) can be managed and controlled remote from electronically placing the micro-bet(s) during the round of micro-betting. Additionally, a portion of a profit can be automatically obtained with respect to the round of micro-bets in exchange for the aforementioned managing and controlling of the wager(s) with respect to the micro-bet(s) during the round of micro-betting.

Abstract: A method and system for micro-betting. One or more micro-bets can be electronically placed with respect to one or more micro-events associated with an event during a round of micro-betting. One or more wages with respect to the micro-bet(s) can be managed and controlled during the round of micro-betting. The wager(s) can be managed and controlled remote from electronically placing the micro-bet(s) during the round of micro-betting. Additionally, a portion of a profit can be automatically obtained with respect to the round of micro-bets in exchange for the aforementioned managing and controlling of the wager(s) with respect to the micro-bet(s) during the round of micro-betting.

Abstract: A modular rolling mill has a mill pass line along which products roll. The rolling mill comprises first gear units arranged along a first line parallel to the mill pass line. Each first gear unit is driven individually by a motor and has a pair of mechanically interconnected first shafts. Second gear units are arranged along a second line between and parallel to the first line and the mill pass line. Each second gear unit has a pair of mechanically interconnected second shafts. Rolling units are arranged along the mill pass line, which are driven by an input shaft and has a pair of roll shafts carrying work rolls. First couplings connect the first shafts of each first gear unit to second shafts of two successive gear units, and second couplings releasably connect the second shafts of the second gear units to the input shafts of two successive rolling units.

Abstract: In a rolling mill in which hot rolled product is formed into rings by a laying head and the rings are transported in an overlapping pattern to a reforming station where the rings are gathered into coils, a method of increasing the time gap between billet lengths of product delivered to the reforming station by advancing the rings of a front end of one billet along said conveyor at a one speed while advancing the rings of a tail end of a preceding billet at another speed greater than said one speed.

Abstract: An apparatus for slitting a hot rolled process section having parallel bars connected to together along at least one of their lengthwise edges, while the process section is moving longitudinally along a rolling line. The apparatus comprises first and second pairs of upper and lower rotatably driven slitting rollers positioned sequentially along the rolling line, with the slitting rollers of each pair being and arranged to engage opposite sides of the process section. The slitting rollers of the first pair have profiles configured to break the connection between at least some of the bars of the process section while allowing the connections between other bars of the process section to remain intact, and the slitting rollers of the second pair have profiles configured to break the remaining intact connections between the other bars of the process section.

Abstract: In a rolling mill in which hot rolled product is formed into rings by a laying head and the rings are transported in an overlapping pattern to a reforming station where the rings are gathered into coils, a method of increasing the time gap between billet lengths of product delivered to the reforming station by advancing the rings of a front end of one billet along said conveyor at a one speed while advancing the rings of a tail end of a preceding billet at another speed greater than said one speed.

Abstract: An apparatus for bundling bars comprises an accumulator rotatable about a horizontal axis. The accumulator has a plurality of notches spaced angularly around its axis. A drive rotates the accumulator about its axis to sequentially locate the notches at a first station at which long bars are received in the notches and accumulated into batches; a second station at which the batches are tied into bundles; and a third station at which the bundles are delivered from the notches to a bundle collector.

Abstract: A modular rolling mill has a mill pass line along which products roll. The rolling mill comprises first gear units arranged along a first line parallel to the mill pass line. Each first gear unit is driven individually by a motor and has a pair of mechanically interconnected first shafts. Second gear units are arranged along a second line between and parallel to the first line and the mill pass line. Each second gear unit has a pair of mechanically interconnected second shafts. Rolling units are arranged along the mill pass line, which are driven by an input shaft and has a pair of roll shafts carrying work rolls. First couplings connect the first shafts of each first gear unit to second shafts of two successive gear units, and second couplings releasable connect the second shafts of the second gear units to the input shafts of two successive rolling units.

Abstract: A method for operating an apparatus for decelerating and temporarily accumulating a hot rolled long product. The product is deposited on a rotating drum in the form of a helix, and is simultaneously unwound from the drum to a receiving guide movable incrementally along a path parallel to the rotational axis of the drum. Immediately upon entry of the product front end into the receiving guide, the incremental movement of the receiving guide is preceded by an initial rapid shifting through a distance adequate to prevent subsequent product convolutions of the helix from buckling and overlapping.

Abstract: A feed product is rolled into different sized finished products in a rolling mill finishing section which comprises a plurality of modular rolling units arranged along the mill pass line. Each rolling unit includes two roll stands with work rolls configured to define successive oval and round roll passes. The roll stands are designed to effect specific area reductions on products rolled through their respective oval and round roll passes. Feed products having the same entry size are rolled into finished products having different reduced sizes by providing altered rolling sequences in which a selected rolling unit is replaced along the pass line with rolling units having roll stands designed to effect area reductions that differ from those of the roll stands of the replaced rolling unit. Rolling units downstream from the replaced rolling unit are removed from the pass line. The roll stands of rolling units upstream from the replaced rolling unit remain unchanged.

Abstract: A method for operating an apparatus for decelerating and temporarily accumulating a hot rolled long product. The product is deposited on a rotating drum in the form of a helix, and is simultaneously unwound from the drum to a receiving guide movable incrementally along a path parallel to the rotational axis of the drum. Immediately upon entry of the product front end into the receiving guide, the incremental movement of the receiving guide is preceded by an initial rapid shifting through a distance adequate to prevent subsequent product convolutions of the helix from budding and overlapping.

Abstract: A modular rolling mill has a mill pass line along which products are rolled in a rolling direction. The rolling mill comprises first gear units arranged along a first line parallel to the mill pass mill line. Each first gear unit is driven individually by a motor and has a pair of mechanically interconnected output shafts. Second gear units are arranged along a second line between and parallel to both the first line and the mill pass line. Each second gear unit has a pair of mechanically interconnected input shafts driving a pair of output shafts. Rolling units are arranged in succession along the mill pass line. Each rolling unit is driven by an input shaft and has a pair of mechanically interconnected roll shafts carrying work rolls. First couplings connect the output shafts of each first gear unit to input shafts of two successive gear units, and second couplings releasably connect the output shafts of the second gear units to the input shafts of two successive rolling units.

Abstract: A pouring reel for forming a long product moving at an incoming velocity into an annular coil comprises a central mast lying on a vertical axis. A cylindrical tub surrounds and cooperates with the mast to form an annular chamber, the bottom of which is closed by a coil plate. An entry pipe is arranged to deliver the product downwardly for accumulation in the chamber as a series of superimposed rings forming the annular coil. A first drive mechanism rotates the tub about the vertical axis, and a second drive mechanism rotates the mast about the same axis. The first and second drive mechanisms are operable independently of each other to thereby permit the tub and the mast to be rotated at surface velocities substantially matching the incoming velocity of the product.