Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Disclosed herein is a system for storing gas at almost constant pressure, which involves the injection and withdrawal of a liquid in a process known as hydraulic compensation. This disclosure teaches a way to minimize that dissolution by ensuring that, as the gas containment is charged up, the hydraulic compensation liquid emerges from the containment at the gas storage pressure and the pressure of that liquid is caused to fall in a number of discrete steps with settling volumes present at the nodes between these steps. These settling volumes enable some gas to come out of solution at each node having lost relatively small amounts of pressure. The gas is compressed back up to storage pressure and re-injected into the main storage containment without significant use of energy.

Abstract: Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Abstract: Disclosed herein is an automated process of identifying shut-in parameters of a hydraulic fracturing operation from hydraulic fracturing treatment (HF) data. Also disclosed is a system and computer program product for automatically determining shut-in parameters from HF data. The HF data can be collected in real time during a HF from various sensors, equipment, or systems typically used in HFs or present at a well site. In one example, a method for automatically determining hydraulic fracturing parameters includes: (1) obtaining HF data, (2) determining a Rate Shut-In (RSI) time from the HF data, (3) determining a Well Shut-In (WSI) time using the RSI, and (4) calculating an Instantaneous Shut-In Pressure (ISIP) value based upon both the RSI and the WSI times, wherein determining the RSI time, the WSI time and calculating the ISIP value are automatically performed by one or more processors.

Abstract: There is described an apparatus for heating aerosolizable material to volatilize at least one component of the aerosolizable material. The apparatus includes a heating chamber for containing aerosolizable material and a first heater arrangement for heating aerosolizable material contained in use within the heating chamber. The first heater arrangement is arranged to heat at least two sides of the aerosolizable material in the heating chamber. There is further provided an air flow channel outside of the heating chamber that runs alongside the first heater arrangement and is arranged such that, in use, when a user draws on a device comprising the apparatus, air flows into the apparatus and through the air flow channel so as to be preheated in the air flow channel by the first heater arrangement before flowing into the heating chamber and through the aerosolizable material.

Abstract: An electronic pharmacy adjudication system and associated method and computer program product for performing adjudication service for a healthcare insurance claim is provided. The system includes an interface layer, an orchestration layer and a service and rules engine layer configured for receiving, processing and releasing an adjudication decision. The orchestration layer processes the healthcare insurance claim to generate a sequence of service calls to the service and rules engine layer to derive a sequence of partial decision results, which are derived by processing a set of parameters identified by the service call according to a corresponding subset of decisions rules in a rules repository. The sequence of partial decision results is then processed to derive the adjudication decision corresponding to the healthcare insurance claim.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Compounds and compositions that deliver both uridine and ketoleucine are useful in treating disorders characterized by diminished muscle strength or diminished muscle lean mass. One such a compound is 5?-O-ketoleucyl-2?,3?-di-O-acetyluridine.

Abstract: Disclosed herein is a system for storing gas at almost constant pressure, which involves the injection and withdrawal of a liquid in a process known as hydraulic compensation. This disclosure teaches a way to minimize that dissolution by ensuring that, as the gas containment is charged up, the hydraulic compensation liquid emerges from the containment at the gas storage pressure and the pressure of that liquid is caused to fall in a number of discrete steps with settling volumes present at the nodes between these steps. These settling volumes enable some gas to come out of solution at each node having lost relatively small amounts of pressure. The gas is compressed back up to storage pressure and re-injected into the main storage containment without significant use of energy.

Abstract: Disclosed herein is an automated process of identifying shut-in parameters of a hydraulic fracturing operation from hydraulic fracturing treatment (HF) data. Also disclosed is a system and computer program product for automatically determining shut-in parameters from HF data. The HF data can be collected in real time during a HF from various sensors, equipment, or systems typically used in HFs or present at a well site. In one example, a method for automatically determining hydraulic fracturing parameters includes: (1) obtaining HF data, (2) determining a Rate Shut-In (RSI) time from the HF data, (3) determining a Well Shut-In (WSI) time using the RSI, and (4) calculating an Instantaneous Shut-In Pressure (ISIP) value based upon both the RSI and the WSI times, wherein determining the RSI time, the WSI time and calculating the ISIP value are automatically performed by one or more processors.

Abstract: An electronic pharmacy adjudication system and associated method and computer program product for performing adjudication service for a healthcare insurance claim is provided. The system includes an interface layer, an orchestration layer and a service and rules engine layer configured for receiving, processing and releasing an adjudication decision. The orchestration layer processes the healthcare insurance claim to generate a sequence of service calls to the service and rules engine layer to derive a sequence of partial decision results, which are derived by processing a set of parameters identified by the service call according to a corresponding subset of decisions rules in a rules repository. The sequence of partial decision results is then processed to derive the adjudication decision corresponding to the healthcare insurance claim.

Abstract: 5?-O-Phenylacetyluridine effectively delivers both phenylacetate and uridine to a subject. It can be used to treat hepatic encephalopathy and genetic disorders of the hepatic nitrogen cycle.

Abstract: An imidazoquinoline compound having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer is described.

Abstract: Anti-fogging apparatus and methods for protective eyewear which use air flow directed by designed nozzles to the surface of the lens of the protective eyewear are described. The established flow into the mask reduces or eliminates fogging on a lens of the mask. In some examples, air is directed into the interior protective area using nozzles that are positioned at particular angles relative to the lens. Said apparatus operates under particular configurations and with described methodology to improve anti-fogging ability while creating minimal disruption to the user's eyes.

Abstract: An electronic pharmacy adjudication system and associated method and computer program product for performing adjudication service for a healthcare insurance claim is provided. The system includes an interface layer, an orchestration layer and a service and rules engine layer configured for receiving, processing and releasing an adjudication decision. The orchestration layer processes the healthcare insurance claim to generate a sequence of service calls to the service and rules engine layer to derive a sequence of partial decision results, which are derived by processing a set of parameters identified by the service call according to a corresponding subset of decisions rules in a rules repository. The sequence of partial decision results is then processed to derive the adjudication decision corresponding to the healthcare insurance claim.

Abstract: A smoking article filter includes a recess to receive a filter insert unit. The filter insert unit is secured to the filter once inserted. The filter and the filter insert unit may include additives such as flavourants, colourants or sorbents.

Abstract: A smoking article filter includes a recess to receive a filter insert unit. The filter insert unit is secured to the filter once inserted. The filter and the filter insert unit may include additives such as flavourants, colourants or sorbents.

Abstract: A translating actuator acting between two extreme positions defined by mechanical stops is described. Said actuator comprises: an armature mass movable relative to the armature body, a stiff armature spring set such that the natural resting position of the armature mass is close to the centre of travel between the two extreme positions and pair of latches with sufficient holding force that the armature mass can be held at either extreme position against the restoring force of the spring and can be released quickly relative to the natural period of vibration determined by the armature mass on the armature spring.

Abstract: A system for power conversion and energy storage is described. In an embodiment the system comprise a DC rotating electrical machine (1) comprising a DC rotor; an AC rotating electrical machine (2) comprising an AC rotor; and a (thermo-) mechanical energy storage system (known as a TMESS) (3). The TMESS comprises a central shaft, said central shaft charged and discharged with shaft power and selectively mechanically coupled to the DC rotor and to the AC rotor via clutch (4) to form a shaft train. Some source of DC generation such as photovoltaic cells (5) feeds electrical power into the DC electrical machine (1). There may also be local DC loads (8) supported by the system. The AC electrical machine (2) may deliver power to local AC loads (6), or draw power from the AC electrical grid (7).