Patents by Inventor Michael Sotirios Malamas

Michael Sotirios Malamas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino-pyridines As Inhibitors Of Beta-secretase
    Publication number: 20100204245
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: April 20, 2010
    Publication date: August 12, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, JR., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Imidazole Amines As Inhibitors Of Beta-secretase
    Publication number: 20100168091
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated 3-amyloid deposits or 3-amyloid levels in a patient.
    Type: Application
    Filed: March 5, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Keith Douglas Barnes, Matthew Robert Johnson
  • Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone Compounds For The Inhibition Of Beta-secretase
    Publication number: 20100168194
    Abstract: The present invention provides compounds and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: March 10, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, Koi Michele Morris, William R. Solvibile, Ji-In Kim, Schuyler Adam Antane
  • Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation
    Publication number: 20100168106
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-pyridines as inhibitors of ?-secretase
    Patent number: 7732457
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: June 8, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, Jr., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of beta-secretase
    Patent number: 7723368
    Abstract: The present invention provides compounds and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: May 25, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, Koi Michele Morris, William R. Solvibile, Ji-In Kim, Schuyler Adam Antane
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7705030
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: April 27, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Imidazole amines as inhibitors of ?-secretase
    Patent number: 7700606
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Grant
    Filed: August 16, 2007
    Date of Patent: April 20, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Keith Douglas Barnes, Matthew Robert Johnson
  • AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090253716
    Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 8, 2009
    Inventors: Michael Sotirios Malamas, James Joseph Erdei, Iwan Suwandi Gunawan, Pawel Wojciech Nowak, Boyd Lynn Harrison
  • Diphenylimidazopyrimidines as inhibitors of ?-secretase
    Patent number: 7563796
    Abstract: The present invention provides an amino-imidazolone compound of formula I Also provided are compositions and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: July 21, 2009
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, James Joseph Erdei, Iwan Suwandi Gunawan, Pawel Wojciech Nowak, Boyd Lynn Harrison
  • AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090048320
    Abstract: The present invention provides compounds and methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: March 21, 2008
    Publication date: February 19, 2009
    Applicant: WYETH
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, Koi Michele Morris, William R. Solvibile, Ji-In Kim
  • AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION
    Publication number: 20090042908
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: October 10, 2008
    Publication date: February 12, 2009
    Applicant: Wyeth
    Inventors: Ping Zhou, Michael Sotirios Malamas, Yanfang Li, Albert Jean Robichaud, Dominick Anthony Quagliato
  • AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS
    Publication number: 20090042964
    Abstract: The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: March 20, 2008
    Publication date: February 12, 2009
    Applicant: Wyeth
    Inventors: Michael Sotirios Malamas, Albert Jean Robichaud, Alexander Michael Porte, William R. Solvibile, Koi Michele Morris, Schuyler Adam Antane, Ji-In Kim, Robert Emmett McDevitt
  • AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090012139
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: August 29, 2008
    Publication date: January 8, 2009
    Applicant: Wyeth
    Inventors: Michael Sotirios MALAMAS, James Joseph ERDEI, William Floyd FOBARE, Dominick Anthony QUAGLIATO, Schuyler Adam ANTANE, Albert Jean ROBICHAUD
  • AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION
    Publication number: 20080306091
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: July 28, 2008
    Publication date: December 11, 2008
    Applicant: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7452885
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: November 18, 2008
    Assignee: Wyeth
    Inventors: Ping Zhou, Michael Sotirios Malamas, Yanfang Li, Albert Jean Robichaud, Dominick Anthony Quagliato
  • Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of ?-secretase
    Patent number: 7423158
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: September 9, 2008
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, James Joseph Erdei, William Floyd Fobare, Dominick Anthony Quagliato, Schuyler Adam Antane, Albert Jean Robichaud
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7417047
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 26, 2008
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Substituted oxadiazolidinediones
    Patent number: 7351726
    Abstract: The present invention relates generally to substituted oxadiazolidinediones and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: April 1, 2008
    Assignee: Wyeth
    Inventors: Hassan Mahmoud Elokdah, Michael Sotirios Malamas
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Patent number: 7022716
    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael Sotirios Malamas