Patents by Inventor Michael Sotirios Malamas

Michael Sotirios Malamas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Patent number: 6743787
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Publication number: 20030144326
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: December 27, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael Sotirios Malamas
  • Azolidines as beta-3 adrenergic receptor agonists
    Patent number: 6569873
    Abstract: This invention provides compounds of Formula I having the structure wherein, A, X, Y, Z, W, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: May 27, 2003
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, Elwood Eugene Largis, Iwan Gunawan, Zenan Li
  • Azolidines as beta-3 adrenergic receptor agonists
    Publication number: 20030055079
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: August 23, 2002
    Publication date: March 20, 2003
    Applicant: Wyeth
    Inventors: Michael Sotirios Malamas, Elwood Eugene Largis, Iwan Gunawan, Zenan Li
  • N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Publication number: 20030027795
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 25, 2002
    Publication date: February 6, 2003
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Azolidines as &bgr;3 adrenergic receptor agonists
    Patent number: 6465501
    Abstract: This invention provides compounds of Formula I having the structure wherein, A, X, Y, Z, W, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: October 15, 2002
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, Elwood Eugene Largis, Iwan Gunawan, Zenan Li
  • N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Patent number: 6444685
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: September 3, 2002
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas