Patents by Inventor Michael Spaid
Michael Spaid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080143906Abstract: A transparent conductor including a conductive layer coated on a substrate is described. More specifically, the conductive layer comprises a network of nanowires that may be embedded in a matrix. The conductive layer is optically clear, patternable and is suitable as a transparent electrode in visual display devices such as touch screens, liquid crystal displays, plasma display panels and the like.Type: ApplicationFiled: October 12, 2007Publication date: June 19, 2008Applicant: CAMBRIOS TECHNOLOGIES CORPORATIONInventors: Pierre-Marc Allemand, Haixia Dai, Shuo Na, Hash Pakbaz, Florian Pschenitzka, Xina Quan, Jelena Sepa, Michael A. Spaid
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Publication number: 20080090244Abstract: Methods are provided for detecting low copy nucleic acids of interest in a sample. In one method, a sample comprising a nucleic acid of interest is aliquotted into a plurality of reaction mixtures, at least two of which are single-copy reaction mixtures. The reaction mixtures are subjected to one or more amplification reactions while flowing through a channel of a microfluidic device. At least one of the reaction mixtures is formulated in an aqueous phase of an emulsion comprising aqueous droplets suspended in an immiscible liquid. The nucleic acid of interest is present as a single copy in at least one aqueous droplet of the aqueous phase prior to performing the amplification reaction(s). Amplification is performed on the reaction mixture when it is formulated in the emulsion. The nucleic acid is continuously flowed during a plurality of steps of the method.Type: ApplicationFiled: October 17, 2007Publication date: April 17, 2008Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Michael Knapp, Jill Baker, Andrea Chow, Anne Kopf-Sill, Michael Spaid
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Publication number: 20080085521Abstract: Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.Type: ApplicationFiled: October 4, 2007Publication date: April 10, 2008Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Michael Knapp, Jill Baker, Andrea Chow, Anne Kopf-Sill, Michael Spaid
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Publication number: 20070261479Abstract: The present invention relates to novel methods and systems for determining the interaction of molecules using the phenomenon of Taylor-Aris dispersion present in fluid flow in conduits. The method involves relating a change in dispersion of molecules to their level of interaction. The present invention also relates to an assay method using Taylor-Aris dispersion in a microfluidic system in order to examine molecular interactions in a variety of chemical and biochemical systems.Type: ApplicationFiled: May 18, 2007Publication date: November 15, 2007Applicant: Caliper Technologies, Corp.Inventors: Michael Spaid, Jeffrey Wolk
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Publication number: 20070154895Abstract: This invention provides systems and methods of running multiple different analyses on a microfluidic device.Type: ApplicationFiled: December 30, 2005Publication date: July 5, 2007Applicant: Caliper Life Sciences, Inc.Inventors: Michael Spaid, Anne Kopf-Sill, Cheryl Cathey
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Publication number: 20070151852Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: ApplicationFiled: November 7, 2006Publication date: July 5, 2007Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Ring-Ling Chien, J. Parce, Michael Spaid
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Publication number: 20070074316Abstract: A transparent conductor including a conductive layer coated on a substrate is described. More specifically, the conductive layer comprises a network of nanowires which may be embedded in a matrix. The conductive layer is optically transparent and flexible. It can be coated or laminated onto a variety of substrates, including flexible and rigid substrates.Type: ApplicationFiled: August 14, 2006Publication date: March 29, 2007Applicant: Cambrios Technologies CorporationInventors: Jonathan Alden, Haixia Dai, Michael Knapp, Shuo Na, Hash Pakbaz, Florian Pschenitzka, Xina Quan, Michael Spaid, Adrian Winoto, Jeffrey Wolk
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Patent number: 7160423Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: GrantFiled: March 4, 2003Date of Patent: January 9, 2007Assignee: Caliper Life Sciences, Inc.Inventors: Ring-Ling Chien, J. Wallace Parce, Michael Spaid
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Publication number: 20060254503Abstract: A seed layer is formed on a substrate using a first biological agent. The seed layer may comprise densified nanoparticles which are bound to the biological agent. The seed layer is then used for a deposition of a metal layer, such as a barrier layer, an interconnect layer, a cap layer and/or a bus line for a solid state device.Type: ApplicationFiled: May 15, 2006Publication date: November 16, 2006Inventors: Haixia Dai, Khashayar Pakbaz, Michael Spaid, Theo Nikiforov
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Publication number: 20060254502Abstract: Improved methods and articles providing conformal coatings for a variety of devices including electronic, semiconductor, and liquid crystal display devices. Peptide formulations which bind to nanoparticles and substrates, including substrates with trenches and vias, to provide conformal coverage as a seed layer. The seed layer can be further enhanced with use of metallic films deposited on the seed layer. Seed layers can be characterized by AFM measurements and improved seed layers provide for better enhancement layers including lower resistivity in the enhancement layer. Peptides can be identified by phage display.Type: ApplicationFiled: November 16, 2005Publication date: November 16, 2006Applicant: Cambrios Technologies CorporationInventors: Philip Garrou, Michael Knapp, Hash Pakbaz, Florian Pschenitzka, Xina Quan, Michael Spaid
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Publication number: 20060254504Abstract: An aqueous substrate surface treatment composition includes cysteine and an acidic solution having a pH of about 7 or less. The composition enables a selective deposition of a metal ion sensitizer and a subsequent selective plating of a metallic cap layer. Various CoWP plating bath compositions are also provided which may be used to form the cap layer.Type: ApplicationFiled: May 15, 2006Publication date: November 16, 2006Inventors: Haixia Dai, Khashayar Pakbaz, Michael Spaid, Theo Nikiforov
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Patent number: 7101467Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated (and can be concentrated) by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: GrantFiled: December 22, 2003Date of Patent: September 5, 2006Assignee: Caliper Life Sciences, Inc.Inventor: Michael A. Spaid
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Publication number: 20060188979Abstract: A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperature of the fluid within the microchannels is controlled in various ways including the use of electrical resistive heating elements and by providing zones located in contact with the top and bottom layers of the microfluidic device for circulating heat transfer of fluid therein.Type: ApplicationFiled: December 30, 2005Publication date: August 24, 2006Applicant: Caliper Life Sciences, Inc.Inventors: Michael Spaid, Andrea Chow, Yevgeny Yurkovetsky, Seth Stern, Allen Boronkay, Morten Jensen, Carlton Brooks, Ken Swartz
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Patent number: 7040144Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures, other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: GrantFiled: July 26, 2002Date of Patent: May 9, 2006Assignee: Caliper Life Sciences, Inc.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill, Josh Molho, Anubhav Tripathi, Matthew B. Kerby
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Patent number: 6990851Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: GrantFiled: December 5, 2003Date of Patent: January 31, 2006Assignee: Caliper Life Sciences, Inc.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
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Publication number: 20050135655Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: ApplicationFiled: January 13, 2005Publication date: June 23, 2005Applicant: Caliper Life Sciences, Inc.Inventors: Anne Kopf-Sill, Andrea Chow, Peter Jann, Morten Jensen, Michael Spaid, Colin Kennedy, Michael Kennedy
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Publication number: 20050133370Abstract: This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,Type: ApplicationFiled: June 12, 2004Publication date: June 23, 2005Applicants: Caliper Life Sciences, Inc., Wako Pure Chemical Industries, Ltd.Inventors: Charles Park, Persefoni Kechagia, Michael Spaid, Morten Jensen, Irina Kazakova, Josh Molho, Tomohisa Kawabata, Mitsuo Watanabe
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Publication number: 20050121324Abstract: This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.Type: ApplicationFiled: September 7, 2004Publication date: June 9, 2005Applicant: Caliper Life Sciences, Inc.Inventors: Charles Park, Persefoni Kechagia, Michael Spaid, Morten Jensen, Irina Kazakova, Josh Molho
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Patent number: 6881312Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: GrantFiled: December 13, 2002Date of Patent: April 19, 2005Assignee: Caliper Life Sciences, Inc.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael J. Kennedy
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Publication number: 20050042639Abstract: Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.Type: ApplicationFiled: May 14, 2004Publication date: February 24, 2005Applicant: Caliper Life Sciences, Inc.Inventors: Michael Knapp, Jill Baker, Andrea Chow, Anne Kopf-Sill, Michael Spaid