Patents by Inventor Michael Stocks

Michael Stocks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING
    Publication number: 20250129092
    Abstract: Compounds of the general formula (I) as described and defined herein, methods for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds and pharmaceutical compositions for the treatment or prevention of diseases, in particular cancer or conditions with dysregulated immune functions, or other conditions associated with aberrant AhR signalling, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: August 31, 2022
    Publication date: April 24, 2025
    Inventors: Michael STOCKS, Mark GRAHAM, James HITCHIN, Tom MCINALLY, Vincenzo CILIBRASI, Sandy COMPAIN, Davide SBRAVATI
  • PYRIDOPYRIMIDINE DERIVATIVES USEFUL IN MODULATION OF AHR SIGNALLING
    Publication number: 20230279000
    Abstract: The present disclosure relates to compounds of formula (I). Compounds of formula (II), Compounds of formula (III), Compounds of formula (IV), Compounds of formula (V), Compounds of formula (VI), Compounds of formula (VII), in particular inhibitors if AhR, pharmaceutical formulation comprising any one of the same, use of said compounds or compositions in treatment, in particular treatment of cancer.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 7, 2023
    Inventors: Mark GRAHAM, James HITCHIN, Sarah MAJOR, Michael STOCKS, Wendy TOMLINSON
  • Novel Benzothiazolone Derivatives
    Publication number: 20100210688
    Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: April 27, 2010
    Publication date: August 19, 2010
    Inventors: Roger Bonnert, Alice Flaherty, Garry Pairaudeau, Michael Stocks
  • Benzothiazolone derivatives
    Patent number: 7709511
    Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: May 4, 2010
    Assignee: AstraZeneca AB
    Inventors: Roger Bonnert, Alice Flaherty, Garry Pairaudeau, Michael Stocks
  • N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES
    Publication number: 20100081670
    Abstract: The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
    Type: Application
    Filed: May 5, 2009
    Publication date: April 1, 2010
    Inventors: Andrew Baxter, Timothy Johnson, Nicholas Kindon, Bryan Roberts, Michael Stocks
  • N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases
    Patent number: 7662825
    Abstract: The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: February 16, 2010
    Assignee: AstraZeneca AB
    Inventors: Andrew Baxter, Timothy Johnson, Nicholas Kindon, Bryan Roberts, Michael Stocks
  • Alkyl Esters Of Cyclic Amino Alcohols With Muscarinic M3 Receptor Antagonist Activity, Useful For Treating E.G. Chronic Bronchial Obstruction, Asthma And Overactive Bladder
    Publication number: 20090233965
    Abstract: The invention provides compounds of formula (I), wherein R1, R2, R3, R4, R5 and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions and their use in therapy (I).
    Type: Application
    Filed: April 23, 2007
    Publication date: September 17, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Andrew Bailey, Antonio Mete, Garry Pairaudeau, Michael Stocks, Mark Wenlock
  • 7-(2-amino-1-hydroxy-ethyl)-4-hydroxybenzothiazol-2(3H)-one-derivatives as beta2 adrenoreceptor agonists
    Publication number: 20090221653
    Abstract: The present invention provides compounds of formula (I) wherein the variables are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 28, 2006
    Publication date: September 3, 2009
    Applicant: AstraZeneca AB
    Inventors: Andrew Bailey, Roger Bonnert, Stephen Connolly, Anthony Ingall, Garry Pairaudeau, Michael Stocks
  • 7-(2-amino-1-hydroxy-ethyl)-4-hydroxybenzothiazol-2(3H)-one-derivatives as beta2 adrenoreceptor agonists
    Publication number: 20090203753
    Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4?, R5?, R6, R7, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 28, 2006
    Publication date: August 13, 2009
    Applicant: AstraZeneca AB
    Inventors: Andrew Bailey, Roger Bonnert, Alice Flaherty, Garry Pairaudeau, Michael Stocks
  • PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS
    Publication number: 20090029958
    Abstract: The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.
    Type: Application
    Filed: March 6, 2007
    Publication date: January 29, 2009
    Inventors: Lilian Alcaraz, Andrew Bailey, Rhona Cox, Premji Meghani, Garry Pairaudeau, Michael Stocks
  • Novel Adamantane Derivatives
    Publication number: 20090018133
    Abstract: The invention provides compounds of formula (I), in which m, A, R1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 15, 2009
    Inventors: Rhonan Ford, Frederic Leroux, Michael Stocks
  • Novel Benzothiazolone Derivatives
    Publication number: 20080300275
    Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: August 3, 2006
    Publication date: December 4, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Roger Bonnert, Alice Flaherty, Garry Pairaudeau, Michael Stocks
  • Compounds
    Patent number: 7410972
    Abstract: The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: August 12, 2008
    Assignee: AstraZeneca AB
    Inventors: Andrew Baxter, Timothy Johnson, Nicholas Kindon, Bryan Roberts, John Steele, Michael Stocks, Nicholas Tomkinson
  • Novel condensed n-pyrazinyl-sulphonamides and their use in the treament of chemokine mediated diseases
    Publication number: 20070093491
    Abstract: The invention provides novel condensed N-pyrazinyl-sulphonamides of formula (I) and their use in the treatment of chemokine mediated diseases.
    Type: Application
    Filed: August 25, 2004
    Publication date: April 26, 2007
    Inventors: Andrew Baxter, Nicholas Kindon, Michael Stocks
  • N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation
    Patent number: 7129246
    Abstract: The invention provides compounds of general formula (I) in which m, A, R1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: October 31, 2006
    Assignee: AstraZeneca AB
    Inventors: Lilian Alcaraz, Timothy Johnson, Michael Stocks
  • N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases
    Publication number: 20060025423
    Abstract: The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
    Type: Application
    Filed: January 14, 2003
    Publication date: February 2, 2006
    Inventors: Andrew Baxter, Timothy Johnson, Nicholas Kindon, Bryan Roberts, Michael Stocks
  • Novel adamantane derivatives
    Publication number: 20050090524
    Abstract: The invention provides compounds of formula, in which m, A, R?1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
    Type: Application
    Filed: March 24, 2003
    Publication date: April 28, 2005
    Inventors: Rhonan Ford, Frederic Leroux, Michael Stocks
  • Novel compounds
    Publication number: 20050075346
    Abstract: The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
    Type: Application
    Filed: December 17, 2002
    Publication date: April 7, 2005
    Inventors: Andrew Baxter, Timothy Johnson, Nicholas Kindon, Bryan Roberts, John Steele, Michael Stocks, Nicholas Tomkinson
  • N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation
    Publication number: 20050010052
    Abstract: The invention provides compounds of general formula (I) in which m, A, R1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
    Type: Application
    Filed: November 12, 2002
    Publication date: January 13, 2005
    Inventors: Lilian Alcaraz, Timothy Johnson, Michael Stocks
  • Pyridine derivatives and pharmaceutical compositions containing them
    Patent number: 6300352
    Abstract: The invention relates to novel pyridyl derivatives, their use as medicaments, pharmaceutical formulations containing them and methods for their preparation.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: October 9, 2001
    Assignee: AstraZeneca AB
    Inventors: David Cheshire, David Cladingboel, Simon Hirst, Carol Manners, Michael Stocks