Abstract: A reference architecture embodies a common, consistent, known best practice base reference architecture and configuration that may then be used for cloning out for the base of every customer environment. Given this base, the service provider is able to control the full functionality solution layer to provide the platform for consistent monitoring, patching, upgrading, etc. Accordingly, the service provider's application solution is an integrated appliance that can contain whatever is necessary at the solution layer to allow the service provider to remotely (or within the hosting center) support, maintain and gather key system metrics to promote optimal customer performance, decrease cost of implementation/support/ownership and vastly increase service offering base.

Abstract: A plenum for guiding a flow of cooling air through the interior of a computer is designed to maximize the airflow over those electrical components within the computer which are most sensitive to temperature, and/or which require the greatest amount of cooling. The plenum is designed to be mounted over top of a computer motherboard which includes a plurality of electrical components mounted thereon. One or more apertures are formed in the lower wall of the plenum so that electrical components mounted on the computer motherboard can protrude through the apertures and into the interior of the plenum. The lower surface of the plenum is designed to prevent the flow of cooling air passing through the plenum from escaping through the apertures on the lower wall. Also, upper and lower protrusions on the plenum can extend into the interior of the plenum to concentrate the flow of cooling air onto the electrical components which are protruding through the apertures and into plenum.

Abstract: A method, system and computer program product to detect and indicating TFR zone violations, potential TFR zone violations or TFR zones in vicinity of an aircraft and indicating measures to avoid or exit a TFR zone are provided. TFR zone information and an aircraft's position information are received. The aircraft's position information is processed to determine the aircraft's current heading. A TFR zone violation is determined based on the aircraft's current position. A potential TFR violation is determined based on whether the aircraft's current heading intersects a TFR zone. The presence of a TFR zone in the vicinity of the aircraft is determined based on the aircraft's current position and heading. Indicators of a TFR violation, potential TFR violation, no TFR violation or TFR zones in the vicinity are provided. If a TFR violation, or possible TFR violation or TFR zone in the vicinity are found, measures are indicated to exit the TFR zone or change the aircraft's current heading to avoid the TFR zone.

Abstract: A process for the production of a valuable compound, comprising the steps of a) fermentation of a filamentous bacterial or fungal strain (e.g. a Streptomyces strain or an Aspergillus strain) in a fermentation medium wherein a carbohydrate during fermentation is added in a cyclic pulse dosing/pause way, wherein the pulse dosing time is shorter than the pause time and b) recovery of the valuable compound from the fermentation broth.

Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.

Abstract: The invention provides N-pyrazinyl-phenyl-sulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.

Abstract: A method, system and computer program product to detect and indicating TFR zone violations, potential TFR zone violations or TFR zones in vicinity of an aircraft and indicating measures to avoid or exit a TFR zone are provided. TFR zone information and an aircraft's position information are received. The aircraft's position information is processed to determine the aircraft's current heading. A TFR zone violation is determined based on the aircraft's current position. A potential TFR violation is determined based on whether the aircraft's current heading intersects a TFR zone. The presence of a TFR zone in the vicinity of the aircraft is determined based on the aircraft's current position and heading. Indicators of a TFR violation, potential TFR violation, no TFR violation or TFR zones in the vicinity are provided. If a TFR violation, or possible TFR violation or TFR zone in the vicinity are found, measures are indicated to exit the TFR zone or change the aircraft's current heading to avoid the TFR zone.

Abstract: The invention provides compounds of formula (I), wherein R1, R2, R3, R4, R5 and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions and their use in therapy (I).

Abstract: The present invention provides compounds of formula (I) wherein the variables are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4?, R5?, R6, R7, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.

Abstract: The invention provides compounds of formula (I), in which m, A, R1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

Abstract: The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases.

Abstract: An offset lithographic printing press combined with a gapped or seamed cylindrical offset printing blanket having pre-made blanket material mounted on a cylindrical sleeve is disclosed, wherein conventional, manufactured blanket material in flat form is adhered to a cylindrical sleeve to economically produce a cylindrical sleeved blanket. The leading and trailing ends of the flat blanket material are joined in close proximity such that a small gap is formed. A seam may be made with a filler material that fills the remaining gap resulting in a seamed sleeved blanket. In use, the blanket's printing surface, which excludes the gap or seam, is aligned with the printing plate's image-bearing surface. Consequently, no loss of print length results from the gap or seam.

Abstract: A projectile according exemplary embodiments generally includes a body. The body has a generally cylindrical proximal portion and an ogival distal portion terminating at a distal rim. The ogival distal portion includes a distal-facing aperture extending inwardly from the distal rim into the body. The projectile also includes a nose element. The nose element has a proximal section extending at least partially into the distal-facing aperture, and an ogival distal section external to the distal-facing aperture. At least a portion of the nose element is at least partially light transmissive through which at least some ambient light is transmissible and visually perceptible to an observer.

Abstract: A projectile according to exemplary embodiments generally includes a jacket with nose, middle, and heel portions. The nose portion includes a forward cavity. The heel portion includes a rearward cavity having sidewalls. A dense core is within the rearward cavity and bonded to the sidewalls. Upon upset of the projectile, the portion of the jacket forming the forward cavity peels generally back toward the heel portion thereby forming petals, and the sidewalls and the dense core axially compress and radially expand to define a bulge portion, with the jacket material substantially covering the dense core material thereby inhibiting exposure of the dense core material to the upset media.

Abstract: A laser scanning microscope comprises at least one selectively switchable micro-mirror arrangement (DMD) in the illumination beam path and/or detection beam path which is used for the wavelength selection of dispersively divided illumination and/or object light such as reflection, fluorescence.