Abstract: A vehicle component and method of forming a vehicle component. The vehicle component includes an additively-manufactured (AM) structure with a first end and a second end opposing the first end. The AM structure includes a pathway from the first end to the second end and a non-AM structure that passes along the pathway from the first end to the second end. The non-AM structure and the AM structure are fixedly connected to one another at a connection.

Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a glycol or sugar alcohol, optionally an alkali or alkaline salt and an amino acid; and formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar of at least 150 mg/ml, a carrier, and optionally an alkali or alkaline salt and an amino acid.

Abstract: Aspects are provided for additively manufacturing a build piece using tile-based printing with dynamic beam shaping. An apparatus may include a powder bed depositor that deposits a layer of powder material in a powder bed, a laser beam source configured to produce a laser beam, a beam shaping component configured to adjust an energy profile of the laser beam to obtain a beam energy profile, and a controller. The controller can be configured to obtain information of the layer of powder material and control the beam shaping component to adjust a beam energy profile of the laser beam to correspond to tile energy profiles associated with a plurality of tiles in the layer. Further, the controller can be configured to apply a pulse of the laser beam to the plurality of tiles to fuse portions of the build piece corresponding to respective tiles.

Abstract: Alloyed metals, and techniques for creating parts from alloyed metals, are disclosed. An apparatus in accordance with an aspect of the present disclosure comprises an alloy. An additive manufacturing alloy in accordance with the present disclosure may comprise magnesium (Mg) that is between 2.0 and 5.3% by weight, manganese (Mn) that is between 0.01 and 4.0% by weight, silicon (Si) that is between 0.1 and 1.5% by weight, zirconium (Zr) that is between 0.01 and 2.0% by weight, and aluminum (Al). In some cases, the alloy such as described in the previous sentence might not include Mg.

Abstract: A system and method are provided for compensating for thermal drift of a probe device. The method includes monitoring a first temperature of a laser source in a sensor head that receives output electrical signals from a DUT and outputs corresponding optical signals; monitoring a second temperature of a photoreceiver in a probe interface that converts the optical signals to electrical test signals to input to the test instrument; calculating a first value of a first bias voltage using the first temperature; applying the first value of the first bias voltage to the laser source to compensate for thermal drift when the first temperature is within a first predefined temperature range; calculating a second value of a second bias voltage for the photoreceiver using the second temperature; and applying the second value of the second bias voltage to the photoreceiver to compensate for thermal drift when the second temperature is within a second predefined temperature range.

Abstract: A rotor lock assembly for locking a rotor of a wind turbine. The rotor lock assembly has at least one relocatable rotor lock. The relocatable rotor lock has a housing, a bushing element, a pin shaft position within the bushing element, and a locking mechanism. The housing includes a mounting portion adapted for mounting to a bearing housing adjacent to a rotor lock plate of the rotor.

Abstract: Embodiments relate to a system and method for managing energy consumption of one or more processor cores in a multicore processing device. The method includes establishing a temporal interval that includes a plurality of temporal periods and an interval energy target for one or more processor cores. The method also includes determining for each temporal period a period energy target for the processor cores and determining a processor core throttling state for the processor cores. The method further includes adjusting the respective period energy target and the respective processor core throttling state at the beginning of each successive temporal period. The method also includes converging, subject to the adjusting, as each respective temporal period of the plurality of temporal periods is concluded, a total period energy consumption of the processor cores with the interval energy target.

Abstract: A container may include a generally hollow body configured for holding a liquid and including a spout. A spout cap may be configured for removable engagement with the spout. The spout cap may include an inner boss and an outer boss in fluid communication with the inner boss. The inner boss may include an annular skirt disposed within an interior space of the spout cap. The outer boss may be configured to receive a connector of a hose assembly. A filter may have a connecting portion configured for removable insertion into the inner boss. The filter and the spout cap may form a fluid flow path from the body through the spout. Related filters, hose assemblies, and kits are also described.

Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

Abstract: An iron-air battery including an iron electrode in contact with an anode current collector, wherein the iron electrode includes a plurality of channels; an oxygen reduction reaction electrode having a first surface facing the plurality of channels and an opposing second surface in contact with air; an oxygen evolution reaction electrode interdigitated with the plurality of channels of the iron electrode, wherein at least a portion of the oxygen evolution reaction electrode is disposed within the plurality of channels in a direction perpendicular to a plane of the oxygen reduction reaction electrode; and an electrolyte in contact with the iron electrode, the first surface of the oxygen reduction reaction electrode, the plurality of channels, and the oxygen evolution reaction electrode.

Abstract: A power flow control system is disclosed. The system includes impedance injection modules (IIMs) distributed along and connected in series to one or more power transmission lines. The system further includes dual-ring fiber optic networks, with each dual-ring fiber optic network including a pair of fiber rings that provide data flow in opposite directions. The system further includes redundant power line coordinators in communication with the IIMs through the dual-ring fiber optic networks.

Abstract: A machine learning approach is herein provided for preparing a model for assessing the progression of a lung disease, comprises receiving a first set of segmented images of lungs from different patients with the lung disease. The first set of images is segmented and used to train the model. The trained model is applied to a set of unsegmented images to generate a second set of segmented images. The model is updated with the second set of segmented segmentation. From the model, at least one result associated with progression of the lung disease is outputted.

Abstract: A vessel rinsing apparatus including a mounting base, a fluid discharge member including a plurality of nozzles, a valve member operably coupled to the fluid discharge member and configured to control water flow through the nozzles, and an escutcheon supported by the mounting base.

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

Abstract: Systems and methods for generating a shared collaborative channel for collaboration are provided. In particular, a computing device may receive a request, from an originating member of an organization, to create the shared collaborative channel, the request including an invitee to be added to the shared collaborative channel. In response to receipt of the request, the computing device may provision a substrate group by creating a container associate with the shared collaborative channel including a substrate database associated with the shared collaborative channel, generate an invitation including a custom link to the shared collaborative channel for the invitee, and determine whether the invitee belongs to an originating collaboration team associated with the originating member based on the substrate database. If the invitee belongs to the originating collaboration team, the computing device may further update the substrate group to add the invitee as a new member of the shared collaborative channel.

Abstract: Systems and methods of forming and removing support structures formed in a powder bed fusion (PBF) system are provided. The support structures are formed with designated failure zones that are designed to fail in a controlled fashion when resonated by one or more resonation devices.

Abstract: Audio splicing is rendered more effective by the use of one or more truncation unit packets inserted into the audio data stream so as to indicate to an audio decoder, for a predetermined access unit, an end portion of an audio frame with which the predetermined access unit is associated, as to be discarded in playout.

Abstract: An optical waveguide adapter assembly comprises a solid core optical waveguide extending between a free end and a coupled end and having a solid waveguiding core with an associated first optical mode field size; a hollow core optical waveguide extending between a free end and a coupled end and having a hollow waveguiding core with an associated second optical mode field size; and an optical mode field adapter extending between a first end and a second end and having a waveguiding core configured to change an optical mode field of a waveguided optical signal substantially between the first optical mode field size at the first end of the optical mode field adapter and the second optical mode field size at the second end of the optical mode field adapter, the first end of the optical mode field adapter joined to the coupled end of the solid core optical waveguide to provide optical coupling between the waveguiding core of the solid core optical waveguide and the waveguiding core of the optical mode field adapter

Abstract: Herein is reported a method for determining the binding interaction with a multimeric antigen of an antibody of the human IgG1 subclass that has at least two binding sites specifically binding to the antigen comprising the steps of 1) determining the binding affinity of the antibody for the multimeric antigen, and 2) incubating a mixture comprising the antibody and a polypeptide that is derived from lysine-gingipain of Porphyromonas gingivalis under conditions and for a time sufficient to cleave the antibody into Fabs and Fc-region, and determining the binding affinity of the Fabs of the antibody for the multimeric, whereby the binding affinity of the antibody to the multimeric antigen to be affinity-driven if the binding affinity determined in both steps are comparable and to be avidity-driven if the binding affinity determined in both steps are different.

Abstract: The present invention discloses a process for engineering a host cell comprising the steps of; a) integrating a first polynucleotide cassette including a first selection marker flanked by a first pair of recombination sites; b) removing the first selection marker by the action of a recombinase which recognises the first pair of recombination sites; c) integrating a second polynucleotide cassette including a second selection marker flanked by a second pair of recombination sites; and d) removing the second selection marker by the action of a recombinase which recognises the second pair of recombination sites. Also disclosed is a host cell genome polynucleotide comprising a first recombinantly engineered region and a second recombinantly engineered region, wherein a first single recombination site is adjacent to the first recombinantly engineered region, and a second single recombination site is adjacent to the second recombinantly engineered region.