Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Abstract: A cover for transmission levers for vehicles that are pivotally mounted at one end and the distal end includes a handle. A sac assembly with a double liner covers the handle and with an engagement assembly at the opening of the sac assembly it is removably mounted over the handle. Another embodiment includes an engagement assembly that uses a threaded tubular member that is removably mounted to the threaded distal end of the lever. In both embodiments a compartment is provided with granular material contained therein. A relatively soft object results with still sufficient rigid characteristics to transmit the force applied by a user to shift the gears. The sac assembly also provides desirable gripping qualities to permit a user to dissipate his anxiety and stress.