Patents by Inventor Michael W. Rey

Michael W. Rey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7186513
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: March 6, 2007
    Assignee: Novozymes, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
  • Patent number: 7172891
    Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 6, 2007
    Assignee: Novozymes, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
  • Patent number: 7098001
    Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: August 29, 2006
    Assignee: Novozymes, Inc.
    Inventors: Alexandeer Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
  • Patent number: 7033811
    Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: April 25, 2006
    Assignee: Novozymes, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
  • Patent number: 6902887
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: June 7, 2005
    Assignees: Novozymes Biotech, Inc., Novozymes A/S
    Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
  • Patent number: 6893839
    Abstract: The present invention relates to methods for producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the heterologous polypeptide, wherein (i) the mutant cell comprises a nucleic acid sequence encoding the heterologous polypeptide and (ii) the mutant produces less of the cyclohexadepsipeptide than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the heterologous polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated cyclohexadepsipeptide synthetases and isolated nucleic acid sequences encoding the cyclohexadepsipeptide synthetases.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: May 17, 2005
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Wendy T. Yoder
  • Publication number: 20040229367
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
    Type: Application
    Filed: August 29, 2003
    Publication date: November 18, 2004
    Applicants: Novozymes Biotech, Inc., Novozymes A/S, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
  • Publication number: 20040171104
    Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: November 25, 2003
    Publication date: September 2, 2004
    Applicant: Novozymes Biotech, Inc.
    Inventors: Alexander Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
  • Patent number: 6756220
    Abstract: The present invention relates to isolated polypeptides having lactonohydrolase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. The present invention further relates to methods for preventing microbial biofilm development.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: June 29, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey
  • Patent number: 6730346
    Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: May 4, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler
  • Publication number: 20040067569
    Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: April 18, 2003
    Publication date: April 8, 2004
    Applicant: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
  • Patent number: 6692940
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO. 1, nucleotides 1 to 938 of SEQ ID NO. 2, and nucleotides 1 to 3060 of SEQ ID NO. 3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: February 17, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
  • Patent number: 6686189
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: February 3, 2004
    Assignee: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Patent number: 6682922
    Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: January 27, 2004
    Assignees: Novozymes Biotech, Inc., Novozymes Bioindustry, Ltd.
    Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
  • Patent number: 6667169
    Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 23, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Patent number: 6664092
    Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: December 16, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Alexander Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
  • Publication number: 20030180418
    Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.
    Type: Application
    Filed: May 5, 2003
    Publication date: September 25, 2003
    Applicants: Novozymes Biotech, Inc., Novozymes A/S
    Inventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler
  • Publication number: 20030148452
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO. 1, nucleotides 1 to 938 of SEQ ID NO. 2, and nucleotides 1 to 3060 of SEQ ID NO. 3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Application
    Filed: October 28, 2002
    Publication date: August 7, 2003
    Applicant: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
  • Publication number: 20030100092
    Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: October 2, 2002
    Publication date: May 29, 2003
    Applicant: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
  • Patent number: 6558715
    Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: May 6, 2003
    Assignees: Novozymes Biotech, Inc., Novozymes A/S
    Inventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler