Patents by Inventor Michael W. Rey
Michael W. Rey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7186513Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: August 29, 2003Date of Patent: March 6, 2007Assignee: Novozymes, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 7172891Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: December 6, 2005Date of Patent: February 6, 2007Assignee: Novozymes, Inc.Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
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Patent number: 7098001Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: November 25, 2003Date of Patent: August 29, 2006Assignee: Novozymes, Inc.Inventors: Alexandeer Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
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Patent number: 7033811Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: April 18, 2003Date of Patent: April 25, 2006Assignee: Novozymes, Inc.Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
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Patent number: 6902887Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: March 22, 2000Date of Patent: June 7, 2005Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 6893839Abstract: The present invention relates to methods for producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the heterologous polypeptide, wherein (i) the mutant cell comprises a nucleic acid sequence encoding the heterologous polypeptide and (ii) the mutant produces less of the cyclohexadepsipeptide than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the heterologous polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated cyclohexadepsipeptide synthetases and isolated nucleic acid sequences encoding the cyclohexadepsipeptide synthetases.Type: GrantFiled: January 13, 2000Date of Patent: May 17, 2005Assignee: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Wendy T. Yoder
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Publication number: 20040229367Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: ApplicationFiled: August 29, 2003Publication date: November 18, 2004Applicants: Novozymes Biotech, Inc., Novozymes A/S, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Publication number: 20040171104Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: ApplicationFiled: November 25, 2003Publication date: September 2, 2004Applicant: Novozymes Biotech, Inc.Inventors: Alexander Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
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Patent number: 6756220Abstract: The present invention relates to isolated polypeptides having lactonohydrolase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. The present invention further relates to methods for preventing microbial biofilm development.Type: GrantFiled: April 19, 2002Date of Patent: June 29, 2004Assignee: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey
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Patent number: 6730346Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.Type: GrantFiled: May 5, 2003Date of Patent: May 4, 2004Assignee: Novozymes Biotech, Inc.Inventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler
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Publication number: 20040067569Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: ApplicationFiled: April 18, 2003Publication date: April 8, 2004Applicant: Novozymes Biotech, Inc.Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
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Patent number: 6692940Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO. 1, nucleotides 1 to 938 of SEQ ID NO. 2, and nucleotides 1 to 3060 of SEQ ID NO. 3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.Type: GrantFiled: October 28, 2002Date of Patent: February 17, 2004Assignee: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
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Patent number: 6686189Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: June 12, 2002Date of Patent: February 3, 2004Assignee: Novozymes Biotech, Inc.Inventors: Michael W. Rey, Elizabeth J. Golightly
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Patent number: 6682922Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: October 2, 2002Date of Patent: January 27, 2004Assignees: Novozymes Biotech, Inc., Novozymes Bioindustry, Ltd.Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
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Patent number: 6667169Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: September 19, 2001Date of Patent: December 23, 2003Assignee: Novozymes Biotech, Inc.Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
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Patent number: 6664092Abstract: The present invention relates to isolated polypeptides having dipeptidyl aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: GrantFiled: May 15, 1998Date of Patent: December 16, 2003Assignee: Novozymes Biotech, Inc.Inventors: Alexander Blinkovsky, Kimberly Brown, Michael W. Rey, Alan Klotz, Tony Byun
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Publication number: 20030180418Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.Type: ApplicationFiled: May 5, 2003Publication date: September 25, 2003Applicants: Novozymes Biotech, Inc., Novozymes A/SInventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler
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Publication number: 20030148452Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO. 1, nucleotides 1 to 938 of SEQ ID NO. 2, and nucleotides 1 to 3060 of SEQ ID NO. 3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.Type: ApplicationFiled: October 28, 2002Publication date: August 7, 2003Applicant: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
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Publication number: 20030100092Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.Type: ApplicationFiled: October 2, 2002Publication date: May 29, 2003Applicant: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
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Patent number: 6558715Abstract: The present invention relates to methods for preparing a dough, comprising incorporating into the dough a composition comprising an effective amount of a lipase which improves one or more properties of the dough or a baked product obtained from the dough. The present invention also relates to methods for preparing a baked product. The present invention also relates to compositions comprising an effective amount of such a lipase for improving one or more properties of a dough and/or a baked product obtained from the dough. The present invention further relates to doughs or baked products and to pre-mixes for a dough.Type: GrantFiled: October 31, 2000Date of Patent: May 6, 2003Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Michael W. Rey, Elizabeth J. Golightly, Tina Spendler