Patents by Inventor Michael W. Rey

Michael W. Rey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides having lipase activity and nucleic acids encoding same
    Publication number: 20030040450
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: June 12, 2002
    Publication date: February 27, 2003
    Applicant: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Promoters for expressing genes in a fungal cell
    Patent number: 6518044
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO:1, nucleotides 1 to 938 of SEQ ID NO:2, and nucleotides 1 to 3060 of SEQ ID NO:3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: February 11, 2003
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
  • Polypeptides having lactonohydrolase activity and nucleic acids encoding same
    Publication number: 20030027310
    Abstract: The present invention relates to isolated polypeptides having lactonohydrolase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. The present invention further relates to methods for preventing microbial biofilm development.
    Type: Application
    Filed: April 19, 2002
    Publication date: February 6, 2003
    Applicant: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey
  • Polypeptides having lysophospholipase activity and nucleic acids encoding same
    Patent number: 6489154
    Abstract: The present invention relates to isolated polypeptides having lysophospholipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: December 3, 2002
    Assignees: Novozymes Biotech, Inc., Novozymes Bioindustry, Ltd.
    Inventors: Randy M. Berka, Michael W. Rey, Tony Byun, Ryoko Itami, Noriko Tsutsumi, Alan Klotz
  • Polypeptides having acid phosphatase activity and nucleic acids encoding same
    Publication number: 20020164753
    Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: September 19, 2001
    Publication date: November 7, 2002
    Applicant: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having lipase activity and nucleic acids encoding same
    Patent number: 6432898
    Abstract: The present invention relates to isolated polypeptides having lipase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: August 13, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Polypeptides having lactonohydrolase activity and nucleic acids encoding same
    Patent number: 6395529
    Abstract: The present invention relates to isolated polypeptides having lactonohydrolase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides. The present invention further relates to methods for preventing microbial biofilm development.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: May 28, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey
  • Promoters for expressing genes in a fungal cell
    Patent number: 6361973
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO:1, nucleotides 1 to 938 of SEQ ID NO:2, and nucleotides 1 to 3060 of SEQ ID NO:3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: March 26, 2002
    Assignee: Novozymes Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Kimberly Brown, Stephen H. Brown
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6320103
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: November 20, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having acid phosphatase activity and nucleic acids encoding same
    Patent number: 6309869
    Abstract: The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 30, 2001
    Assignee: Novozymes Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having glucoamylase activity and nucleic acids encoding same
    Patent number: 6309872
    Abstract: The present invention relates to isolated polypeptides having glucoamylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: October 30, 2001
    Assignee: Novozymes Biotech, Inc
    Inventors: Michael W. Rey, Elizabeth J. Golightly
  • Polypeptides having galactose oxidase activity and nucleic acids encoding same
    Patent number: 6277612
    Abstract: The present invention relates to isolated polypeptides having galactose oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: August 21, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Elizabeth Golightly, Randy M. Berka, Michael W. Rey
  • Polypeptides having phytase activity and nucleic acids encoding same
    Patent number: 6221644
    Abstract: The present invention relates to isolated polypeptides having phytase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to composite feeds and methods of reducing phytate levels.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: April 24, 2001
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Alan V. Klotz
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6146864
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptide from Fusarium venenatum. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: November 14, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Debbie Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having galactose oxidase activity and nucleic acids encoding same
    Patent number: 6090604
    Abstract: The present invention relates to isolated polypeptides having galactose oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: July 18, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Elizabeth Golightly, Randy M. Berka, Michael W. Rey
  • Polypeptides having choline oxidase activity and nucleic acids encoding same
    Patent number: 6063607
    Abstract: The present invention relates to isolated polypeptides having choline oxidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: May 16, 2000
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Debbie S. Yaver, Randy M. Berka, Michael W. Rey
  • Polypeptides having 3g6-phytase activity from thermomyces and nucleic acids encoding same
    Patent number: 5866118
    Abstract: The present invention relates to isolated polypeptides having phytase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to composite feeds and methods of reducing phytate levels.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Alan V. Klotz
  • Gene sequence encoding Aspergillus niger catalase-R
    Patent number: 5360901
    Abstract: The invention discloses the application of genetic engineering techniques to create novel strains of A. niger which produce high levels of catalase (catR gene product, catalase-R) while generating minimal sodium gluconate waste material.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: November 1, 1994
    Assignee: Genencor International, Inc.
    Inventors: Randy M. Berka, Timothy Fowler, Michael W. Rey
  • Production of Aspergillus niger catalase-R
    Patent number: 5360732
    Abstract: The invention discloses the application of genetic engineering techniques to create novel strains of A. niger which produce high levels of catalase (catR gene product, catalase-R) while generating minimal sodium gluconate waste material.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: November 1, 1994
    Assignee: Genecor International, Inc.
    Inventors: Randy M. Berka, Timothy Fowler, Michael W. Rey
  • Secretion of heterologous proteins
    Patent number: 4963495
    Abstract: Direct linkage of DNA encoding prokaryotic signals such as E. coli enterotoxin with DNA encoding mature eukaryotic proteins followed by transformation and culture of bacterial hosts characterized by a periplasmic space, yields substantial amounts of periplasmic mature protein.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: October 16, 1990
    Assignee: Genentech, Inc.
    Inventors: Chung N. Chang, Gregory L. Gray, Herbert L. Heyneker, Michael W. Rey