Abstract: Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.

Abstract: A cellular wheel sluice for bulk material comprises a housing (2) having an interior (3), an extraction side cover (18) releasably fastened to the housing (2), a cellular wheel (8) which is arranged in an operational position in the housing (2) so that it can be driven in rotation about a longitudinal axis (7) and which is held on the extraction side cover (18), an extraction device (20) for displacing the cellular wheel (8) between the operational position and an extracted position, wherein the extraction device (20) has a guide unit (21) for guided displacement of the cellular wheel (8) along an extraction direction (41) parallel to the longitudinal axis (7), and an extraction drive (34) arranged fixed to the housing and coupled to the extraction side cover (18) for automatically driven displacement of the extraction side cover (18) with the cellular wheel (8).

Abstract: A multiple-firing clip device includes a hollow shaft defining a lateral opening communicating with an environment and a distal shaft portion between the lateral opening and a distal end opening. A shuttle longitudinally moves on the shaft and comprises a shuttle body defining a lumen surrounding the shaft, a snare, and a snare-extender slide defining a snare track to form a snare travel path in which the snare is disposed from the body and through the track and a portion of the body. The slide moves along a given extent defining a slide distance and a distal end and movement of the slide to the distal end shortens the snare travel path to extend the snare portion through the lateral opening, through the distal shaft portion, and distally out from a distal side of the body longer than the given extent to secure a suture with the snare.

Abstract: A build powder characterization system for an additive manufacturing (AM) machine includes a build powder collection system, a build powder analyzer, and a controller. The build powder collection system configured to collect build powder during an AM machine build campaign. The build powder analyzer configured to receive from the build powder collection system the collected build powder, to analyze selected build powder properties, and to communicate to a controller data reflecting properties of the collected build powder. The controller is configured to process data, received from the build powder analyzer, reflecting properties of the collected build powder.

Abstract: A powder bed fusion (PBF) additive manufacturing (AM) machine includes a build plate configured to function as a platform to support one or more parts built using the PBF AM machine. The build plate further includes a thermal history indicator positioned on the build plate, attached to the build plate, or physically integrated with the build plate such that the thermal history indicator experiences the same temperature as the build plate. The thermal history indicator is configured to display a durable visual indication of achievement of a temperature associated with a post-processing step performed after the one or more parts are built on the build platform.

Abstract: Some embodiments are directed to a cryptographic encrypted computation method (400). The method involves performing a blind rotation of a ciphertext according to a test polynomial. The blind rotation results in an encrypted polynomial product of the test polynomial and a bootstrapping monomial represents the plaintext value as an exponent, modulo a modulus (q) and modulo a quotient polynomial (p(X)). The quotient polynomial p(X) divides an NTT polynomial XM?1 that allows a number-theoretic transform modulo the modulus q, e.g., q is a power of two and p(X)=XN+XN/2+1. The blind rotation is made more efficient by using the NTT, while the test polynomial is defined in such a way that the polynomial product is programmed to have desired output values for respective plaintext values as a fixed coefficient.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: A recapturable external LAA exclusion clip system includes a clip comprising first and second clip struts, at least one of the struts having a connector interface comprising a first portion of a lock, and a delivery device comprising a handle and an end effector. The handle comprises jaw and lock controls. The end effector is connected to the handle and comprises a clevis and first and second jaws. The jaws are connected to the clevis and operatively connected to the jaw control to actively articulate at least one of the jaws with respect to the other. At least one of the jaws has a connector comprising a second portion of the lock operatively connected to the lock control to removably lock with the first portion of the lock. The first and second portions of the lock have a locked state and are configured to unlock the locked state upon actuation of the lock control.

Abstract: A heat exchanger for a refrigerant circuit of an air conditioning system, with a heat exchanger block with a first fluid channel for the flow of refrigerant and with a second fluid channel for the flow of a fluid. The first fluid channel and the second fluid channel are in thermal contact for the exchange of heat. The heat exchanger also includes a third fluid channel having a refrigerant inlet and a refrigerant outlet for the flow of the refrigerant. The first fluid channel is in direct thermal contact with the third fluid channel for the exchange of heat between the refrigerant in the first fluid channel and the refrigerant in the third fluid channel.

Abstract: A ground traversing, electrically driven drone travels along a preprogrammed path that corresponds to pass catcher's travel path during a play, matching the pass catcher's speed and run cuts. The play is wirelessly communicated to the drone by a handheld electronic device located remote of the drone. A target is located on the drone so that a quarterback can throw a football at the target in order to refine the quarterback's timing and accuracy for the play. Sensors onboard the drone track both the football's and quarterback's speed and travel trajectories so that such data can be collected, along with the drone's travel path, and stored onboard the drone's control unit and eventually fed into 3-D reconstruction software for analysis by the quarterback and coaching staff. The target rotates so that the target either faces in a fixed direction or constantly faces the quarterback during execution of drone's maneuvers.

Abstract: The present disclosure provides a multivitamin specifically formulated for patients undergoing CFTR modulator therapy. The multivitamin includes, in various embodiments, pro-vitamin A, vitamin E, a solubilizer, a bile fluid secretion stimulator, vitamin C and a probiotic formulation.

Abstract: Described are various embodiments of a method for managing crop irrigation, and system using same.

Abstract: A method for treating a usable agricultural area by means of a preferably liquid medium or spraying agent. In the method: when the usable area is driven over, the usable area to be treated is recorded transversely to a travel direction of a recording and spraying device by means of a plurality of image-capturing sensor units which each have a recording range; the image information from a sensor unit is processed by means of a local control unit assigned to the sensor unit; when it is necessary to actuate at least one metering valve for the medium or spraying agent, which metering valve is assigned to the particular recording range, information is transmitted between the local control unit and a main control unit on at least one CAN bus system.

Abstract: Described are various embodiments of a method for managing crop irrigation, and system using same.

Abstract: Chromogenic compositions and devices are described herein which, in some embodiments, permit facile and environmentally friendly production while exhibiting efficient and reversible electrochromic activity. In some embodiments, a composite composition comprises one or more chromogenic thiazolothiazoles contained in an aqueous-based polyelectrolyte matrix. The one or more chromogenic thiazolothiazoles can be soluble in the aqueous-based polyelectrolyte matrix, in some embodiments. Moreover, the chromogenic thiazolothiazoles can comprise at least two pyridinium moieties. In some embodiments, the chromogenic thiazolothiazoles undergo a first color change in response to a first electron reduction, and a second color change in response to a second electron reduction.

Abstract: A recapturable external LAA exclusion clip system includes a clip comprising first and second clip struts, at least one of the struts having a connector interface comprising a first portion of a lock, and a delivery device comprising a handle and an end effector. The handle comprises jaw and lock controls. The end effector is connected to the handle and comprises a clevis and first and second jaws. The jaws are connected to the clevis and operatively connected to the jaw control to actively articulate at least one of the jaws with respect to the other. At least one of the jaws has a connector comprising a second portion of the lock operatively connected to the lock control to removably lock with the first portion of the lock. The first and second portions of the lock have a locked state and are configured to unlock the locked state upon actuation of the lock control.

Abstract: The invention relates to a method on a radar measuring system for determining a uniform speed, in which method two antenna pairs, each consisting of a transmitting antenna and a receiving antenna, are mapped to the same position within a virtual antenna arrangement.

Abstract: The application provides a method, system and device for managing pest treatment and crop growth based on pheno logical model, the system comprising one or more network-interfacing sensors configured to acquire and communicate sensed data associated with the one or more crop locations, a digital data storage component for storing, over time, in association with the one or more crop locations, the sensed data, pest treatment application data, crop outcome data, and the pheno logical model for the one or more crop locations that provides pest treatment application suggestions in connection with the sensed data, and a digital data processor in network communication with the digital data storage component and operable to calculate a correlation between said crop outcome data and the pest treatment application data for the one or more crop locations.