Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

Abstract: A circuit for generating an output current includes a control signal generating circuit that is configured to generate a control signal. The control signal is a function of a level of an analog input voltage signal, and a level of the output current is a function of a level of an analog input current signal and the level of the analog input voltage signal.

Abstract: An outer joint member for a joint assembly configured to receive an inner joint includes a wall forming a hollow chamber having a closed end and an open end. A plurality of restrictors are coupled to the hollow chamber each having a portion thereof extending outwardly from the inner surface of the wall of the hollow chamber. The plurality of restrictors extending from the inner surface of the wall proximate the open end of the hollow chamber.

Abstract: A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic DNA with a plurality of Cas9-gRNA complexes, wherein the Cas9-gRNA complexes comprise a Cas9 protein and a set of at least 10 Cas9-associated guide RNAs that are complementary to different, pre-defined, sites in a genome, to produce a reaction mixture; and (b) incubating the reaction mixture to produce at least 5 fragments of the genomic DNA. Also provided is a composition comprising at least 100 Cas9-associated guide RNAs that are each complementary to a different, pre-defined, site in a genome. Kits for performing the method are also provided. In addition, other methods, compositions and kits for manipulating nucleic acids are also provided.

Abstract: Migrating objects from a source service to a target service includes with a migrating system, generating a migration list, the migration list includes a number of objects to migrate from a source service to a target service, loading a number of object migration jobs into a network-accessible work queue, the object migration jobs representing tasks that define how the objects are to migrate, retrieving, from the network-accessible work queue, the object migration jobs via a number of workers, loading the objects from the source service into the target service via the number of workers, and validating file checksums of the objects to ensure data integrity of the objects.

Abstract: Sealable and repositionable implant devices are provided with features that increase the ability of implants such as endovascular grafts and valves to be precisely deployed or re-deployed, with better in situ accommodation to the local anatomy of the targeted recipient anatomic site, and/or with the ability for post-deployment adjustment to accommodate anatomic changes that might compromise the efficacy of the implant. A surgical implant includes an implant body and a selectively adjustable assembly attached to the implant body, the assembly having adjustable elements and being operable to cause a configuration change in a portion of the implant body and, thereby, permit implantation of the implant body within an anatomic orifice to effect a seal therein under normal physiological conditions.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: A fastener clip includes a base plate and a first and second pair of laterally offset legs extending from the base plate. At least one first wing extends from the first pair of laterally offset legs. The at least one first wing has an engagement region. At least one second wing extends from the second pair of laterally offset legs. The at least one second wing also has an engagement region. A first joined portion extends from the first pair of legs and a second joined portion extends from the second pair of legs with the first joined portion and the second joined portion extending and overlapping over and under each other. First locking tabs extend sideways from the first joined portion folded over against the overlapping second portion, and second locking tabs extend sideways from the second joined portion folded over against the overlapping first portion.

Abstract: According to one embodiment, a fastener comprises a first side and a second side opposite the first side. The first side is connected to the second side thereby forming a U-shaped structure. The fastener further comprises a bottom portion wherein the first side and the second side are connected, and a top portion opposite the bottom portion. The first side comprises a first engagement spring. The first engagement spring is connected to the first side in the vicinity of the bottom portion. The engagement springs have inward facing gussets connected to the bottom portion. The second side comprises a second engagement spring. The second engagement spring is connected to the second side in the vicinity of the bottom portion. A cavity is formed between the first side and the second side as will be described below. The engagement springs include an engagement region operable to adapt to variations or movement of a slot.

Abstract: A circuit for generating an output current includes a control signal generating circuit that is configured to generate a control signal. The control signal is a function of a level of an analog input voltage signal, and a level of the output current is a function of a level of an analog input current signal and the level of the analog input voltage signal.

Abstract: A magnetic fastener clip includes a cup having at least one injection hole, an overmold attached to the cup and a magnet is attached to the overmold. The overmold has: a cup cover attached to an outside portion of the cup, and an inner ring attached to an inside portion of the cup. The inner ring is attached to the cup cover via the at least one injection hole. The magnet operably attaches into the inner ring. According to one embodiment, the cup cover and the inner ring are injection molded over at least one part of the cup. An optional coupler for attachment to a body panel is attached to the cup cover and is operative to flex. The magnetic fastener clip adapts to different surface curvatures and thicknesses. The magnetic fastener clip is operative for blind attachment into a structure, such as a vehicle chassis.

Abstract: A magnetic bracket includes a base and at least two posts at opposite ends of the base. The posts bend upwards from the base such that at least two clips are operable to attach at the posts at opposite ends of the base. The posts have a notch between the base and ends of the posts to permit the clips to hook onto the posts. The magnetic bracket may be clipped into a vehicle chassis by removably inserting the clips into a slot of the vehicle chassis. A body panel such as a headliner having a magnetic fastener attached to the body panel may then be magnetically self-aligned and removably attached to the base having a magnetic portion. The magnetic fastener is operable to be removably attached to the magnetic portion. The magnetic bracket is attached to a non-magnetic part of a vehicle chassis.

Abstract: A power conversion circuit includes a voltage boost circuit including a boost inductor configured to generate an output voltage in response to an input voltage, and a boost controller configured to control operation of the voltage boost circuit. The boost controller is configured to control operation of the voltage boost circuit in response to a level of current in the boost inductor.

Abstract: A fastener clip includes a base plate and a first and second pair of laterally offset legs extending from the base plate. At least one first wing extends from the first pair of laterally offset legs. The at least one first wing has an engagement region. At least one second wing extends from the second pair of laterally offset legs. The at least one second wing also has an engagement region. The engagement regions include a depressed portion operable to adapt to variations or movement of a slot.

Abstract: A fire suppression and annunciation system using a flexible conduit and a wire rope is provided. The wire rope may be connected to a knob assembly at a universal pull station and to a release mechanism of the fire suppression system. An operator may pull a handle of the knob assembly at the universal pull station, thereby activating the release mechanism to release fire suppression agent. A flexible conduit may house the wire rope along at least a part of the connection from the universal pull station to the release mechanism. A material on the liner of the flexible conduit and/or on the wire rope may be used to reduce the coefficient of friction of wire rope in the flexible conduit. The fire suppression system may further include a pulley block system connected to the universal pull station. The pulley block system may comprise bearings, and may lower the force necessary to activate the release mechanism.

Abstract: A method and apparatus for forming a bonded joint on a composite structure is presented. An apparatus carrying a first workpiece is positioned relative to a second workpiece. A vacuum is applied to the first workpiece and a portion of the second workpiece. A bladder on a first surface of a housing of the apparatus is deflated. Deflating the bladder positions the first workpiece such that adhesive having a desired thickness is positioned between the first workpiece and the second workpiece. The adhesive positioned between the first workpiece and the second workpiece is cured.

Abstract: A liquid alkylbenzene sulfonate composition comprising a salt of alkylbenzene sulfonate (preferably a calcium or DMAPA salt) and a liquid alcohol alkoxylate is disclosed. This composition is useful as an emulsifier. It is solvent-free and non-flammable and has low odor.

Abstract: A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location.

Abstract: A pole bracket magnetically attaches a magnetic cable fastener to a magnetic object such as a building structure such as a frame, electrical box, conduit, truss, I-beam, car body, vehicle chassis or any suitable object. For example, the pole bracket removably attaches to and holds the magnetic cable fastener to hold a cable to the building structure. The pole bracket has a base having a pole attachment portion to attach to a pole. The pole bracket also has a magnetic clip holder section coupled to the base. The magnetic clip holder section includes a snap stem portion operable to removably hold the magnetic cable fastener. As the magnetic fastener is positioned as desired via the pole bracket, the magnetic fastener is magnetically self-aligned with and removably attached to the building structure.

Abstract: A fire suppression and annunciation system using a flexible conduit and a wire rope is provided. The wire rope may be connected to a knob assembly at a universal pull station and to a release mechanism of the fire suppression system. An operator may pull a handle of the knob assembly at the universal pull station, thereby activating the release mechanism to release fire suppression agent. A flexible conduit may house the wire rope along at least a part of the connection from the universal pull station to the release mechanism. A material on the liner of the flexible conduit and/or on the wire rope may be used to reduce the coefficient of friction of wire rope in the flexible conduit. The fire suppression system may further include a pulley block system connected to the universal pull station. The pulley block system may comprise bearings, and may lower the force necessary to activate the release mechanism.