Abstract: At a managed control plane service, constituent services and operational requirements of an application are identified. In response to an end-user request directed to the application, contents of an inter-service request are generated at a resource selected by the managed control plane service for a first constituent service, and a response to the message is generated at another resource selected for a second constituent service. Tasks to be performed for the operational requirements are initiated by the managed control plane service.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.

Abstract: In certain instances, a data management application (software application) that manages moving data files, and the like, from a primary high-speed storage system. An end-user can configure the data management application for particular files via management policies. Based on the management policies, after a file is migrated from the primary storage system to a targeted secondary storage system, a breadcrumb pointing to a webpage for the migrated file is left behind in the primary storage system. The webpage can be used to manage the migrated file, such as moving the migrated file back to the primary storage system.

Abstract: A database management engine provides a user interface that allows users to access and modify employee information in a database. The database includes entries for employees, and each database entry includes identifying information about the associated employee. A user can request to modify data within database entries, for instance in order to update information associated with an employee. Responsive to the request, the database management engine identifies liabilities associated with the database modification stemming from associated tax laws. Based on the identified tax liabilities, the engine computes the aggregate tax liability owed by the employer and/or employee. Before modifying a database entry, the engine modifies the user interface to include interface elements detailing the computed aggregate tax liability. The user explicitly can be required to confirm the database modification in view of the aggregate tax liability.

Abstract: Proxied multi-factor authentication using credential and authentication management in scalable data networks is described, including initiating a request by an extension to authenticate a browser to access a data network, the request being associated with an address and transmitted over HTTP, receiving at a proxy browser a first message from the data network in response to the request, the first message comprising authentication data, the authentication data being forwarded to a server in data communication with the proxy browser and the browser, sending a second message from the server to the extension, the second message comprising the authentication data, and transferring authentication data to the data network from the browser and the extension in response to an query from the data network.

Abstract: In certain instances, a data management application (software application) that manages moving data files, and the like, from a primary high-speed storage system. An end-user can configure the data management application for particular files via management policies. Based on the management policies, after a file is migrated from the primary storage system to a targeted secondary storage system, a breadcrumb pointing to a webpage for the migrated file is left behind in the primary storage system. The webpage can be used to manage the migrated file, such as moving the migrated file back to the primary storage system.

Abstract: The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.

Abstract: A recapturable external LAA exclusion clip system includes a clip comprising first and second clip struts, at least one of the struts having a connector interface comprising a first portion of a lock, and a delivery device comprising a handle and an end effector. The handle comprises jaw and lock controls. The end effector is connected to the handle and comprises a clevis and first and second jaws. The jaws are connected to the clevis and operatively connected to the jaw control to actively articulate at least one of the jaws with respect to the other. At least one of the jaws has a connector comprising a second portion of the lock operatively connected to the lock control to removably lock with the first portion of the lock. The first and second portions of the lock have a locked state and are configured to unlock the locked state upon actuation of the lock control.

Abstract: The invention relates to a method on a radar measuring system for determining a uniform speed, in which method two antenna pairs, each consisting of a transmitting antenna and a receiving antenna, are mapped to the same position within a virtual antenna arrangement.

Abstract: The application provides a method, system and device for managing pest treatment and crop growth based on pheno logical model, the system comprising one or more network-interfacing sensors configured to acquire and communicate sensed data associated with the one or more crop locations, a digital data storage component for storing, over time, in association with the one or more crop locations, the sensed data, pest treatment application data, crop outcome data, and the pheno logical model for the one or more crop locations that provides pest treatment application suggestions in connection with the sensed data, and a digital data processor in network communication with the digital data storage component and operable to calculate a correlation between said crop outcome data and the pest treatment application data for the one or more crop locations.

Abstract: The present disclosure provides a multivitamin specifically formulated with an amended non-staining beta-carotene, or pro-vitamin A. In another aspect, the present disclosure provides a multivitamin for patients undergoing CFTR modulator therapy. The multivitamin includes, in various embodiments, pro-vitamin A, vitamin E, a solubilizer, a bile fluid secretion stimulator, vitamin C and a probiotic formulation.

Abstract: Techniques for modifying intonations in audio files are disclosed. A first audio waveform and a second audio waveform are accessed. A first intonation in the first audio waveform is identified, and a second intonation in the second audio waveform is identified. The first and second intonations correspond to the same unit of pronunciation. The first intonation is modified until it sufficiently matches the second intonation.

Abstract: A U-shaped clamp to attach or snap a conduit or pipe to a slotted structural member. The U-shaped clamp includes a bottom portion, a first side having a first wing connected to the bottom portion; a second side having a second wing connected to the bottom portion thereby forming a U-shaped structure with the first and second sides. The at least one wing snaps into a strut ledge or a rolled edge of the structural member when in an engaged position. The structural member may be a strut or a receiver. The wings engage and snap into curled ends or lips on sides of the strut and thus may adapt the pipe clamp to the strut. Alternatively, the U-shaped clamp may snap into suitably sized strut ledges or a rolled edges on the structural member.

Abstract: A surgical clip delivery device end effector that is configured to implant a clip having a pair of opposing clip struts each having a proximal end and a distal end includes a clevis, a pair of jaws connected to the clevis, and a pair of clip-connecting ends configured to removably connect respectively to the pair of clip struts, at least one of the pair of clip-connecting ends connected to at least one of the pair of jaws with two angular degrees of freedom such that, responsive to connection of the clip struts of the clip to the clip-connecting ends, a movement of the jaws in an initial opening action separates the proximal ends of the clip struts before separating the distal ends of the clip struts.

Abstract: A prosthetic heart valve can comprise a stent frame radially movable between a contracted configuration and a maximum expanded configuration. The stent assembly can comprise a plurality of longitudinally extending jack strut assemblies, wherein each jack strut assembly comprises a proximal jack strut comprising a distal surface, a distal jack strut comprising a proximal surface, and a jack screw connecting the proximal jack strut and the distal jack strut. The proximal surface of each distal jack strut does not contact the distal surface of each respective proximal jack strut when the stent assembly is in the contracted configuration. The proximal surface of each distal jack strut contacts the distal surface of each respective proximal jack strut when the stent assembly is in the maximum expanded configuration.

Abstract: A recapturable external LAA exclusion clip system includes a clip comprising first and second clip struts, at least one of the struts having a connector interface comprising a first portion of a lock, and a delivery device comprising a handle and an end effector. The handle comprises jaw and lock controls. The end effector is connected to the handle and comprises a clevis and first and second jaws. The jaws are connected to the clevis and operatively connected to the jaw control to actively articulate at least one of the jaws with respect to the other. At least one of the jaws has a connector comprising a second portion of the lock operatively connected to the lock control to removably lock with the first portion of the lock. The first and second portions of the lock have a locked state and are configured to unlock the locked state upon actuation of the lock control.

Abstract: An evaluation device for obtaining a segmentation of an environment from a radar recording of the environment, that has an input interface configured to obtain initial training data, where the initial training data comprise radar data of the radar recording and initial characteristics of objects located in the environment recorded with a radar sensor that generates the radar recordings, and where the evaluation device is configured to forward propagate an artificial neural network with the initial training data to obtain second characteristics of the objects determined with the artificial neural network in the forward propagation, and to obtain weighting factors for neural connections of the artificial neural network through backward propagation of the artificial neural network with the differences between the second characteristics and the initial characteristics, in order to obtain the segmentation of the environment through renewed forward propagation with these radar data.

Abstract: Control and/or regulating system (200) for an agricultural working machine (100)—in particular, a distribution machine for spreading material over an agricultural area—comprising a plurality of actuating elements (103) that can be controlled individually and/or in groups, at least one control unit associated with the actuating elements (103), which control unit is designed to receive and/or send switching commands for the purpose of controlling the actuating elements (103), wherein the switching commands have at least one setting parameter (22, 23) suitable for setting and/or configuring the actuating elements (103), and at least one signal line, by way of which the at least two actuating elements (103) are connected to the control unit for the purpose of signal transmission.

Abstract: A display system comprises a continuous flexible display and two main display supports being hingeably connected with respect to each other between a closed storage position and a planar open position for fixing the flexible display in an open position. Each of the supports is structurally configured to support respectively a first and a second portion of the flexible display, a segment of the flexible display is located between the said respective portions of the flexible display in the open position. The display system comprises a spring force biased mechanism operative in either the open or closed position or both the open and closed positions of the flexible display, biasing said segment of the flexible display in the respective position.