Abstract: A wing panel assembly system includes a wing build station, a stringer staging station, and an overhead gantry sub-system including stringer lifting assemblies having lifting mechanisms and end effectors. The end effector has a stringer holder engaging and holding a stringer. The end effector has an actuator operable to move the stringer holder in at least one direction relative to the lifting mechanism. Each stringer lifting assembly is configured to move the stringer from the stringer staging station to the wing build station located relative to a surface of a skin of the wing panel to place the stringer onto the skin of the wing panel in a determined location.

Abstract: A container for holding product therein during shipment and being returned for reuse has at least one track supported by each side of the container. The container has at least one lockable crossbar assembly extending between opposed tracks. Each lockable crossbar assembly has one or more locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks.

Abstract: A container for holding product therein during shipment and for reuse has tracks supported by each side of the container. Opposed linear tracks are supported by each side of the container. At least one lockable crossbar assembly travels along corresponding tracks at the same level. At least one lockable crossbar assembly has locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks and keep product inside the container during shipment.

Abstract: A container for holding product therein during shipment and for reuse has tracks supported by each side of the container. Opposed linear tracks are supported by each side of the container. At least one lockable crossbar assembly travels along corresponding tracks at the same level. At least one lockable crossbar assembly has locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks and keep product inside the container during shipment.

Abstract: A container for holding product therein during shipment and being returned for reuse has at least one track supported by each side of the container. The container has at least one lockable crossbar assembly extending between opposed tracks. Each lockable crossbar assembly has one or more locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks.

Abstract: A wing panel assembly system includes a wing build station, a stringer staging station, and an overhead gantry sub-system including stringer lifting assemblies having lifting mechanisms and end effectors. The end effector has a stringer holder engaging and holding a stringer. The end effector has an actuator operable to move the stringer holder in at least one direction relative to the lifting mechanism. Each stringer lifting assembly is configured to move the stringer from the stringer staging station to the wing build station located relative to a surface of a skin of the wing panel to place the stringer onto the skin of the wing panel in a determined location.

Abstract: A clamping means in the type of an outer clamping means or an inner clamping means for fixed-clamping of work pieces, for the purpose of rotative processing. For achieving a radial displaceability of the clamping segments thereof, an inclined guide surface of a clamping sleeve or of a clamping mandrel with correspondingly inclined slide surfaces on the clamping segments are used. For the application of force into the clamping segments, at least one coupling element is provided on the housing or on the actuation member. The clamping element is axially fixed to the housing or to the actuation member and engages with at least one clamping segment axially in a form-fit manner in a coupling region between an in axial direction distal guide surface region of the guide surface and an in axial direction proximal guide surface region of the guide surface.

Abstract: A weapon loading system includes a handgun that has a slide and a magazine. A panel is provided and the panel may be worn. A holder is hingedly coupled to the panel and the magazine is removably coupled to the holder. The handgun is selectively positioned on the magazine to facilitate loading the magazine into the handgun with one hand. A block is coupled to the panel. The handgun selectively engages the block when the magazine is loaded into the handgun. The block engages the slide such that the slide is racked when the handgun engages the block. Thus, the handgun may be cocked with one hand.

Abstract: A computer system, a computer-implemented method, and a computer program product for dynamic website instantiation. The system includes an interface component which is configured to receive from a first code reader device a first read notification indicating that a unique code is read for the very first time wherein the unique code includes a reference to a URL portion in combination with an identifier number; and to further receive from the first reader device location data indicating a particular physical location which is associated with the first read notification. Further, a generator component of the computer system is configured to generate, based on the unique code, a particular URL in relation to the particular physical location, the particular URL instantiating a website for the particular physical location. A data storage component of the computer system is configured to persist an association of the unique code with the received location data.

Abstract: A clamping means in the type of an outer clamping means or an inner clamping means for fixed-clamping of work pieces, for the purpose of rotative processing. For achieving a radial displaceability of the clamping segments thereof, an inclined guide surface of a clamping sleeve or of a clamping mandrel with correspondingly inclined slide surfaces on the clamping segments are used. For the application of force into the clamping segments, at least one coupling element is provided on the housing or on the actuation member. The clamping element is axially fixed to the housing or to the actuation member and engages with at least one clamping segment axially in a form-fit manner in a coupling region between an in axial direction distal guide surface region of the guide surface and an in axial direction proximal guide surface region of the guide surface.

Abstract: A clamping device has several clamping element receptacles each with a clamping element held by the clamping element receptacle. The clamping element receptacles have an inclination running obliquely to a clamping direction of the clamping device and by means of which the clamping element is guided. The clamping element has a clamping jaw support and the clamping jaw is connectable to the clamping jaw support. The clamping jaw engages in an undercut provided on the clamping jaw support and is additionally fixed by means of a positive fixing means to the clamping jaw support when it is connected to the clamping jaw support.

Abstract: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.

Abstract: A chuck (10) has a chuck body (12), which is provided with three guide devices (24), on each of which is received a radially movable clamping holder (34) for fixing a workpiece to chuck body (12), the guide device (24) being constructed separately from the chuck body (12). Guide device (24) is integrally joined by a polymer concrete filling (46) to the chuck body (12) for a force transfer between guide device (24) and chuck body (12). There is no need for a particularly precise manufacture of the outer contour of guide device (24) and the recess (20) in chuck body (12), because the polymer concrete (46) is able to compensate tolerances.

Abstract: A chuck body for a clamping chuck for clamping a workpiece has a substantially rotationally symmetrically formed basic body, provided on which is a receiving opening, which is formed as a portion of a cone and is formed for receiving a clamping head in such a way as to transmit force. Attached to the basic body is a deformation sensor, for example as a strain gauge, which is intended and designed for determining a deformation of the basic body in a circumferential direction. In this way, the condition and state of wear of the clamping chuck can be determined.

Abstract: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.

Abstract: A clamping device has several clamping element receptacles each with a clamping element held by the clamping element receptacle. The clamping element receptacles have an inclination running obliquely to a clamping direction of the clamping device and by means of which the clamping element is guided. The clamping element has a clamping jaw support and the clamping jaw is connectable to the clamping jaw support. The clamping jaw engages in an undercut provided on the clamping jaw support and is additionally fixed by means of a positive fixing means to the clamping jaw support when it is connected to the clamping jaw support.

Abstract: A chuck for accommodating a collet chuck, comprising a housing and a chucking tool seat that is assigned to the housing. The chucking tool seat is embedded in the housing as a separate part via an intermediate filling that is made of polymer concrete for connecting the chucking tool seat and the housing. This design has improved properties regarding damping and the total weight while flat sub-areas that are composed of individual guiding plates can additionally be used as clamping areas of the chucking tool seat. Thus a pyramid-type joint is obtained, which could previously be created with the required precision only by using a lot of effort when producing the same from solid material.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: A vice (11) has two clamping jaws (15) for clamping workpieces. Between the clamping jaws (15), there is a tensioning device (18) for multi-part chuck heads that operates in a downward direction. Both the clamping jaws (15) and the tensioning device (18) are simultaneously activated by means of a single activation device (21, 30, 31, 37), wherein the activation device has two levers (21). On the one hand, these levers are pressed apart at one end, while on the other hand, they have a projection (24) that engages with a coupling pipe (25) for synchronized movement. The coupling pipe (25) is used to activate the tensioning device (18).

Abstract: Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neuronal damage.