Abstract: cMET inhibitors can be used in the treatment of glioblastoma, including disseminated glioblastoma harboring MET amplification.

Abstract: A container for holding product therein during shipment and being returned for reuse has at least one track supported by each side of the container. The container has at least one lockable crossbar assembly extending between opposed tracks. Each lockable crossbar assembly has one or more locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks.

Abstract: A container for holding product therein during shipment and for reuse has tracks supported by each side of the container. Opposed linear tracks are supported by each side of the container. At least one lockable crossbar assembly travels along corresponding tracks at the same level. At least one lockable crossbar assembly has locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks and keep product inside the container during shipment.

Abstract: A container for holding product therein during shipment and for reuse has tracks supported by each side of the container. Opposed linear tracks are supported by each side of the container. At least one lockable crossbar assembly travels along corresponding tracks at the same level. At least one lockable crossbar assembly has locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks and keep product inside the container during shipment.

Abstract: A container for holding product therein during shipment and being returned for reuse has at least one track supported by each side of the container. The container has at least one lockable crossbar assembly extending between opposed tracks. Each lockable crossbar assembly has one or more locking assemblies to fix the position of the lockable crossbar assembly relative to the tracks.

Abstract: A weapon loading system includes a handgun that has a slide and a magazine. A panel is provided and the panel may be worn. A holder is hingedly coupled to the panel and the magazine is removably coupled to the holder. The handgun is selectively positioned on the magazine to facilitate loading the magazine into the handgun with one hand. A block is coupled to the panel. The handgun selectively engages the block when the magazine is loaded into the handgun. The block engages the slide such that the slide is racked when the handgun engages the block. Thus, the handgun may be cocked with one hand.

Abstract: A computer system, a computer-implemented method, and a computer program product for dynamic website instantiation. The system includes an interface component which is configured to receive from a first code reader device a first read notification indicating that a unique code is read for the very first time wherein the unique code includes a reference to a URL portion in combination with an identifier number; and to further receive from the first reader device location data indicating a particular physical location which is associated with the first read notification. Further, a generator component of the computer system is configured to generate, based on the unique code, a particular URL in relation to the particular physical location, the particular URL instantiating a website for the particular physical location. A data storage component of the computer system is configured to persist an association of the unique code with the received location data.

Abstract: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.

Abstract: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neuronal damage.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neuronal damage.

Abstract: Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neuronal damage.

Abstract: Systems including both distributed and centralized architectures for providing multiple levels of security using “virtual” switches. Ports and channels are assigned the same time slots on a TDMA bus only when they have matching security levels.

Abstract: A method of enforcing a network security policy including mandatory access control (MAC), discretionary access control (DAC) and integrity control for a secure information network, includes operating a transport guard within a memory partition logically between a protected application running in the partition and a networking stack, and defining ports for the transport guard including (i) an application port for forwarding data to and receiving data from the application, (ii) a data port for receiving data addressed to the application from the networking stack, and for sending data originating from the application to the stack, and (iii) a control port for supplying configuration data to the transport guard. The configuration data corresponds to MAC, DAC and integrity control policies specified by the network for the protected application. The transport guard limits data flow between its protected application and the data ports accordingly.

Abstract: The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-? the TGF-? signaling pathway, including molecules preferably binding to the type I TGF-? receptor (TGF?-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-?-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-?.