Abstract: Novel triazole derivatives of the formula (I), in which R1-R6 and Y have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract: In one embodiment, this invention provides an antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7-30 of the sequence of GIP. In another embodiment, this invention provides a method of treating non-insulin dependent diabetes mellitus in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP). In yet another embodiment, this invention provides a method of improving glucose tolerance in a mammal comprising administering to the mammal an antagonist of glucose-dependent insulinotropic polypeptide (GIP).

Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.

Abstract: An oil filter for an internal combustion engine with a cup-shaped housing that is releasably connectable to a receiving head. The housing has a first interlocking element that extends across at least a portion of the outer circumference of the housing and is interrupted by at least one axially extending recess. The filter element has a liquid-tight canister provided on its outer surface with second interlocking elements, which fit into the recesses of corresponding first interlocking elements when the filter element is installed in the housing.

Abstract: In one embodiment, this invention provides an antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7-30 of the sequence of GIP. In another embodiment, this invention provides a method of preventing and treating obesity and non-insulin dependent diabetes mellitus (Type II) in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP). In yet another embodiment, this invention provides a method of improving glucose tolerance in a mammal comprising administering to the mammal an antagonist of glucose-dependent insulinotropic polypeptide (GIP).

Abstract: In a method of drying molds or mold parts for the manufacture of optical lenses, in particular ophthalmic lenses and especially contact lenses, the mold or mold part to be dried is exposed to drying air. For this purpose, humid pressurized air (T) is used to which the mold or mold part is exposed.

Abstract: In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.

Abstract: Novel phenylpyrazole derivatives of the formula (I), in which R1-R6, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role

Abstract: Novel 1,5 diphenylpyrazole derivatives of the formula (I), in which R1-R6 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Abstract: A dynamic data-modeling system and a content management framework combined into a high-level application development framework is disclosed. In one embodiment, the system for application development, comprises a data-modeling framework configured to enable a user to define a logical data model. The data-modeling framework dynamically translates the logical data model into a corresponding physical data model. The changes to the logical data model are automatically adjusted in the physical data model accordingly. A content management framework is coupled to the data-modeling framework. The content management framework is configured to provide tools to enable the user to manage content associated with the physical data model based on the logical data model.

Abstract: An exchangeable filter (10), e.g. for filtering lubricating oil in internal combustion engines, having a housing (11) including a vessel (12), a lid (13) and a seal (25). A filter element (21) is situated inside the housing (11) in such a way that an oil inlet (18) is sealingly separated from an oil outlet (19). The lid (13) has a seal holder (15), in which a groove (27) for receiving the seal (25) is arranged. The seal (25) preferably has a beveled area (26), which projects at least partially beyond the seal holder (15). As a result of this beveled area (26), only small mounting forces are required to mount the exchangeable filter (10).

Abstract: This invention relates to compounds of the formula (I) in which R1, R2, R3, X and Q are as defined above and their use as PDE IV inhibitors.

Abstract: Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

Abstract: A computer system includes a memory and a processor coupled with the memory, configured to assign to each of a plurality of processes a corresponding amount of committed memory from a memory pool, the memory pool including committed memory and uncommitted memory; and dynamically allocate an additional amount of memory required by one of the plurality of processes from the uncommitted memory in the memory pool. Managing memory includes assigning to each of a plurality of processes a corresponding amount of committed memory from a memory pool, the memory pool including committed memory and uncommitted memory; and dynamically allocating an additional amount of memory required by one of the plurality of processes from the uncommitted memory in the memory pool.

Abstract: The invention relates to a display device for motor vehicles and a method for control of a display device for motor vehicles, particularly motor vehicles which require an additive in addition to the fuel for operation thereof, which is used up as a function of the fuel used and further driving parameters. By means of the inventive display device, the range of the additive reservoir is displayed with relation to the range of a full fuel tank.

Abstract: A method includes extracting at least one object file from a library of object files. The method also includes identifying an interprocedural optimization associated with a plurality of object files. The plurality of object files includes the at least one extracted object file. The method further includes invoking recompilation of at least one of the plurality of object files to implement the identified interprocedural optimization. In addition, the method includes generating at least one executable file using the at least one recompiled object file. The plurality of object files could include interprocedural summary information generated by a compiler during a compilation of at least one source file and a compiler internal representation associated with the compiler during the compilation. The interprocedural optimization could be identified using the interprocedural summary information, and the at least one recompiled object file could be generated using the compiler internal representation.

Abstract: The present invention provides a model train operating, sound and control system that provides a user with increased operating realism. Disclosed is a novel remote control communication capability between the user and the model trains. This feature is accomplished by using a handheld remote control on which various commands may be entered, and a Track Interface Unit that retrieves and processes the commands. The Track Interface Unit converts the commands to modulated signals (preferably spread spectrum signals) which are sent down the track rails. The model train picks up the modulated signals, retrieves the entered command, and executes it through use of a processor and associated control and driver circuitry. Another novel feature disclosed is a speed control circuit located inside the model train that is capable of continuously monitoring the operating speed of the train and making adjustments to a motor drive circuit.