Abstract: A method includes extracting at least one object file from a library of object files. The method also includes identifying an interprocedural optimization associated with a plurality of object files. The plurality of object files includes the at least one extracted object file. The method further includes invoking recompilation of at least one of the plurality of object files to implement the identified interprocedural optimization. In addition, the method includes generating at least one executable file using the at least one recompiled object file. The plurality of object files could include interprocedural summary information generated by a compiler during a compilation of at least one source file and a compiler internal representation associated with the compiler during the compilation. The interprocedural optimization could be identified using the interprocedural summary information, and the at least one recompiled object file could be generated using the compiler internal representation.

Abstract: A chimney cap that permits compact storage and quick installation is described. The chimney cap is at least partially hinged, which permits the cage to be quickly set up from a folded condition. This is accomplished by hingeably coupling the sides of the cage to the bottom of the cage. The sides are coupled together by inserting a pin into concentric knuckles formed when corresponding edges are joined together. The folded product may be stored for transport or sale in a substantially flat box.

Abstract: In one embodiment, this invention provides an antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7–30 of the sequence of GIP. In another embodiment, this invention provides a method of preventing and treating obesity and non-insulin dependent diabetes mellitus (Type II) in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP). In yet another embodiment, this invention provides a method of improving glucose tolerance in a mammal comprising administering to the mammal an antagonist of glucose-dependent insulinotropic polypeptide (GIP).

Abstract: Patterns with feature sizes of less than 50 microns are rapidly formed directly in semiconductors, particularly silicon, GaAs, indium phosphide, or single crystalline sapphire, using ultraviolet laser ablation. These patterns include very high aspect ratio cylindrical through-hole openings for integrated circuit connections; singulation of processed die contained on semiconductor wafers; and microtab cutting to separate microcircuit workpieces from a parent semiconductor wafer. Laser output pulses (32) from a diode-pumped, Q-switched frequency-tripled Nd:YAG, Nd:YVO4, or Nd:YLF is directed to the workpiece (12) with high speed precision using a compound beam positioner. The optical system produces a Gaussian spot size, or top hat beam profile, of about 10 microns. The pulse energy used for high-speed ablative processing of semiconductors using this focused spot size is greater than 200 ?J per pulse at pulse repetition frequencies greater than 5 kHz and preferably above 15 kHz.

Abstract: A biopsy device includes a housing and at least one biopsy mechanism moveably connected to the housing. The biopsy can be provided on a biopsy arm. An actuator moves the biopsy arm and operates the biopsy mechanism. The biopsy arms with the biopsy mechanisms are preferably removable from the housing, such that the housing can be used again for subsequent biopsy procedures.

Abstract: Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors have sequences with lengths from 11 to 16 amino acids, inclusive. These inhibitors potently inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-?-peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat ?-amyloid-associated diseases, notably Alzheimer's disease.

Abstract: A chimney liner adaptor is provided to allow air to flow between the outside environment and an annular space in a lined chimney flue. The adaptor may allow an air cooling system to operate but prevents undesirable elements from entering the annular space. The liner adaptor may be disposed between the chimney cap and the top walls of the chimney system and around the chimney liner. The adaptor may include perforated material, such as an expanded metal mesh, a metal screen, stamped metal screen, rugged netting, or the like. The perforated material permits gas flow, provides structural support for other elements of the adaptor, and filters out undesirable objects from entering the chimney.

Abstract: A machine for anticipatory sensing and intervention to avoid swimmer entrapment, with an active pre-entrapment sensor (e.g. ultrasonic) that assesses the relative hazard based on swimmer proximity to the drain cover. An Ultrasonic Transducer launches waves into the suction piping and/or drain system, and to receive echoes from the drain cover, swimmer limbs, hair or body, and the water surface parellel to the drain cover. A Transmitter/Pulser electrically energizes the ultrasonic transducer to launch waves into the suction piping and/or drain system, A Receiver/Processor detects the echoes electrical signals from the the ultrasonic transducer and to receive echoes from objects of interest beyond the pool drain. A Logic and Control element converts the detected signals into reliable information regarding a swimmer safety/hazard status. An Output provides a pump shutdown command when required. Solutions for both new construction and retrofit are described.

Abstract: A method and apparatus for reporting policy violations in messages is described. In one embodiment, a violation is identified by detecting fragments in a message that match information from any one or more rows within a tabular structure of source data. The fragments that match this information are then specified as part of reporting the violation.

Abstract: A device for applying a medicament to a tissue such as the interior wall of a body canal includes a housing having a treatment end for insertion into the body canal. At least one treatment arm is movably connected to the housing and has thereon at least one applicator for applying the medicament to the canal wall. At least one actuator is provided for moving the treatment arm outward relative to the housing and toward the canal wall, and for operating the applicator to apply the medicament to the canal wall. A method for applying a medicament to a tissue such as an interior wall of a body canal is also disclosed.

Abstract: The present invention concerns the use of various forms of GIP-receptor antagonists to attenuate the insulin response to GIP following meals in animals, such as humans, to prevent, reduce, inhibit and/or treat nonalcoholic fatty liver disease by virtue of its prevention and/or reversal of hyperinsulinemia and insulin resistance. Thus, the use of the GIP-receptor antagonists in any effective form is believed to prevent the development and reverse the process of NAFLD. The present invention is accomplished by administering an effective amount of an antagonistic agent, such as a GIP antagonist or an antisense molecule, to antagonize, block, inhibit or ablate the receptor to Glucose-Dependent Insulinotropic Polypeptide (GIP).

Abstract: A biopsy device includes a housing and at least one biopsy mechanism moveably connected to the housing. The biopsy can be provided on a biopsy arm. An actuator moves the biopsy arm and operates the biopsy mechanism. The biopsy arms with the biopsy mechanisms are preferably removable from the housing, such that the housing can be used again for subsequent biopsy procedures.

Abstract: The present invention is directed to methods for hormone delivery to patients suffering from a condition associated with a hormone deficiency. The method involves transducing stem cells, such as bone marrow derived stem cells, with a hormone gene under the control of a cell-type specific promoter such as the glucose-responsive GIP promoter, such that the hormone gene is expressed only after the stem cells differentiate into the cells which express the cell-type specific promoter, and administering the stem cells to the patient. A preferred embodiment of the present invention is the use of GIP-insulin gene expression in K cells of the gut to treat diabetes.

Abstract: A face mask comprising mini pleats which are sized and configured to create a standing seam, that structurally forms a breathing chamber when the face mask is placed upon a user's face.

Abstract: In one embodiment, this invention provides an antagonist of glucose-dependent insulinotropic polypeptide (GIP) consisting essentially of a 24 amino acid polypeptide corresponding to positions 7-30 of the sequence of GIP. In another embodiment, this invention provides a method of treating non-insulin dependent diabetes mellitus in a patient comprising administering to the patient an antagonist of glucose-dependent insulinotropic polypeptide (GIP). In yet another embodiment, this invention provides a method of improving glucose tolerance in a mammal comprising administering to the mammal an antagonist of glucose-dependent insulinotropic polypeptide (GIP).

Abstract: A face mask for covering a wearer's mouth, nose or both, with a single layer non-entraining filter medium which repulses or rejects particulate matter rather than catching or entraining particulate matter.

Abstract: A system for coupling components of toy assemblages, educational models, hobby constructions, component attachments, or the like together using a compact single point snap together axial connector, which is configured or formed with a key like portion included as part of the male connector part, and a corresponding female connector configured to prevent rotational movement about the connectors axis, and/or to limit the selective attachment of the components.