Abstract: The present invention relates to a method of purifying whole HCV particles, the method comprising the steps of a) providing a cell culture supernatant comprising virus particles, b) purification and/or concentration of the cell culture supernatant, c) purification and/or concentration of the product of above step b) using steric exclusion chromatography (SXC) at alkaline pH in the range of 8-10, d) purification and/or concentration of the product of the above step c) using sulphated cellulose membrane absorbers (SCMA), e) obtaining whole virus particles.

Abstract: A filter-drying device having a compressed-air connector and at least one filter connector, wherein the filter-drying device is adapted to fluidically connect the compressed-air connector to the at least one filter connector in a first functional state and to fluidically separate it from the at least one filter connector in a second functional state, wherein the at least one filter connection is adapted to receive a filter, in particular a multi-usable ventilating filter, and to form an airtight connection between the filter-drying device and the filter.

Abstract: The invention relates to a coupling device with at least one first connector, at least one second connector, at least one third connector and a valve device, wherein the at least one first connector is adapted to fluidically connect a media supply filter test device to the coupling device, wherein the at least one second connector is adapted to fluidically connect a multiplier device to the coupling device, wherein the at least one third connector is configured as a hot steam connector, wherein the at least one first connector, the at least one second connector and the at least one third connector are flow connected to the valve device, wherein the valve device is adapted to connect, in a first operating mode, at least one third connector of the at least one third connector fluidically simultaneously to at least one first connector of the at least one first connector and to at least one second connector of the at least one second connector, so that the media supply filter test device connected to the coupl

Abstract: A fastening arrangement fastens a sample holder to a force measuring device. The fastening arrangement has a sample holder, a counterpart holder on the side of the force measuring device. The counterpart holder has a sample holder receptable. The sample holder has a planar abutment surface and the sample holder receptacle has a flat counterpart abutment surface. The sample holder has a positioning element and a fixing element. The sample holder receptacle has a counterpart positioning element and a counterpart fixing element. The positioning element and the counterpart positioning element uniquely define a relative position between the sample holder and the counterpart holder together with the abutment surface and the counterpart abutment surface. The fixing element and the counterpart fixing element hold the sample holder and the counterpart holder against one another and force the abutment surface and the counterpart abutment surface against one another.

Abstract: The invention relates to a fastening assembly (3) for fastening a test device holder (5) to a force measuring apparatus (1), having a test device holder (5) and a slide part (7) which can be or is arranged on a force measurement tower (9) of the force measuring apparatus (1) in such a way that the slide part can move in the vertical direction of the force measurement tower (9). The test device holder (5) has at least one position defining element (11), and the slide part (7) has at least one counter position defining element (13).

Abstract: The invention relates to a force measuring arrangement (3) in particular for applying a test parameter to a specimen and/or for measuring a resistance force applied by the specimen, having at least one force absorption element (25), a first fastening device and a force transmission element (27), wherein the force absorption element (25) can be fastened to a force measuring device in a movable manner by means of the first fastening device, wherein the force absorption element (25) is designed to measure a relative force acting between two force absorption regions, namely a first force absorption region and a second force absorption region (51), wherein the first fastening device is able to be connected to the force absorption element (25) in a force-transmitting manner via the first force absorption region, wherein the second force absorption region (51) is able to be connected to the force transmission element (27) in a force-transmitting manner by means of a second fastening device, wherein the force transmi

Abstract: The present invention relates to a method of purifying whole HCV particles, the method comprising the steps of a) providing a cell culture supernatant comprising virus particles, b) purification and/or concentration of the cell culture supernatant, c) purification and/or concentration of the product of above step b) using steric exclusion chromatography (SXC) at alkaline pH in the range of 8-10, d) purification and/or concentration of the product of above step c) using sulphated cellulose membrane absorbers (SCMA), e) obtaining purified whole virus particles.

Abstract: In a first aspect, the present invention relates to a method for the purification of virus compositions as well as biological macromolecular compounds in a sample comprising mixing the sample with osmolytes, like non-ionic organic polymers and contacting the mixed sample with a hydrophilic membrane, optionally washing the membrane, and eluting the virus preparations or biological macromolecular components from the membrane with an eluting solution containing reduced amounts or no osmolytes, like non-ionic organic polymer. Moreover, virus compositions and biological macromolecular components obtainable with the method according to the present invention are provided as well as the use of the method according to the present invention for purification of virus compositions including whole virus particles and virus-like particles or biological macromolecular components.

Abstract: The invention relates to a force measuring arrangement (3) in particular for applying a test parameter to a specimen and/or for measuring a resistance force applied by the specimen, having at least one force absorption element (25), a first fastening device and a force transmission element (27), wherein the force absorption element (25) can be fastened to a force measuring device in a movable manner by means of the first fastening device, wherein the force absorption element (25) is designed to measure a relative force acting between two force absorption regions, namely a first force absorption region and a second force absorption region (51), wherein the first fastening device is able to be connected to the force absorption element (25) in a force-transmitting manner via the first force absorption region, wherein the second force absorption region (51) is able to be connected to the force transmission element (27) in a force-transmitting manner by means of a second fastening device, wherein the force transmi

Abstract: The invention relates to a fastening arrangement (3) for fastening a sample holder (7) to a force measuring device (1), having a sample holder (7), and a counterpart holder (5) on the side of the force measuring device, which is formed or arranged on the force measuring device (1) or is fixedly connectable to the force measuring device (1), wherein the counterpart holder (5) has at least one sample holder receptacle (19, 21), wherein the sample holder (7) has a planar abutment surface (39) and the sample holder receptacle (19, 21) has a flat counterpart abutment surface (23), wherein the sample holder (7) furthermore has at least one positioning element (41, 43) and one fixing element (45), and the sample holder receptacle (19, 21) has at least one counterpart positioning element (25, 27) and one counterpart fixing element (29), wherein the positioning element (41, 43) and the counterpart positioning element (25, 27) are configured to uniquely define a relative position between the sample holder (7) and th

Abstract: The invention relates to a fastening assembly (3) for fastening a test device holder (5) to a force measuring apparatus (1), having a test device holder (5) and a slide part (7) which can be or is arranged on a force measurement tower (9) of the force measuring apparatus (1) in such a way that the slide part can move in the vertical direction of the force measurement tower (9). The test device holder (5) has at least one position defining element (11), and the slide part (7) has at least one counter position defining element (13).

Abstract: In a first aspect, the present invention relates to a method for the purification of virus compositions as well as biological macromolecular compounds in a sample comprising mixing the sample with osmolytes, like non-ionic organic polymers and contacting the mixed sample with a hydrophilic membrane, optionally washing the membrane,and eluting the virus preparations or biological macromolecular components from the membrane with an eluting solution containing reduced amounts or no osmolytes, like non-ionic organic polymer. Moreover, virus compositions and biological macromolecular components obtainable with the method according to the present invention are provided as well as the use of the method according to the present invention for purification of virus compositions including whole virus particles and virus-like particles or biological macromolecular components.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: The invention relates to plastisols which even without the addition of adhesion promoters exhibit high adhesion to metallic and cathodically deposition-coated substrates.

Abstract: The invention relates to a leak test for filled and closed plastic bottles (5), wherein the plastic bottles (5) are led past a testing device (9) in a positionally stable manner, wherein the testing device (9) comprises an (optoelectric) detection system (10) and a pressure medium system (11), wherein the detection system (10) and at least one controllable valve (17) of the pressure medium system (11) are connected to an evaluation and control unit (15), wherein at least one or more pressure medium pulses having variable durations or a duration of 1 ms to 6 ms are generated when the plastic bottle (5) is led past a nozzle (16) of the pressure medium system (11), wherein each pressure medium pulse applies a punctiform load on a bottle wall region (18), wherein at least one light source (12, 13) or a laser beam of a laser distance sensor (23) of the detection system (10) illuminates or irradiates at least the bottle wall region (18) loaded by the pressure medium pulse at the same time as the pressure medium pul

Abstract: A brake disc comprising a friction surface which has regions comprising recesses, wherein the recesses can vary in the circumferential direction in such a manner that the recesses are formed and/or are arranged such that the recesses in total in the radial direction do not exert any transverse forces on the brake pad.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/ or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: There is described a system for controlling the temperature in a structure that has exterior walls. At least a portion of at least one exterior wall comprises a cement core having a layer of insulation on an interior face and an exterior face of the cement core, and at least one fluid conduit embedded in the cement core. A source of temperature-controlled fluid is connected to the at least one fluid conduit.