Abstract: This patent application relates to a transdermal therapeutic system (TTS) that comprises a Rotigotine-containing cement layer, characterized in that the cement layer contains a hot-meltable adhesive in which Rotigotine as the active substance is dispersed and partly or completely dissolved.

Abstract: By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.

Abstract: This invention features a compound of the following formula:

Abstract: An improved Transdermal Delivery System (TDS) comprising a backing layer inert to the components of the matrix, a selfadhesive matrix containing an amine-functional drug and a protective foil or sheet to be removed prior to use, characterized in that

Abstract: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.

Abstract: The modular power supply of the present invention provides a new device and method for powering multiple portable and/or small devices each requiring an AC or DC current source at one of various low-voltage levels. The invention comprises a main power base that is capable of converting AC power levels in common use internationally into a main low-level DC bus, which may, for example, be 24VDC. The AC input source and the derived DC voltage are then supplied via separate buses to smaller power “blocks” of two distinct designs, one for transforming the AC bus voltage to a low-voltage AC output, and one for converting the DC bus voltage to a low-voltage DC output. The DC blocks are of a common design, but are differentiated in that their respective output voltages are set by a “programming” element. The AC blocks are of a second common design, but are differentiated in that their respective output voltages are set by a “programming” transformer.

Abstract: An apparatus, a system and a method are provided for a ring having a hinge and shaped to encompass a finger or other member of an individual as well as a system and method for using the apparatus. The apparatus may have two arc sections. Each arc section may have a cavity located at an end of the arc sections. One of the cavities may have a male portion. The apparatus may also have an ornament. The ornament may have a female portion sized to receive the male portion. The male portion and cavities may support the ornament when the ring is in a closed state. One arc section may be positioned towards a second arc section at the hinge.

Abstract: A transdermal therapeutic system for transcutaneous administration of sexual steroid hormones over long time periods, and a solvent-free method for the production thereof, is disclosed. The steroid hormones are subjected to as little thermal exposure as possible, thereby avoiding decomposition of the steroid hormones.

Abstract: A stable therapeutical transdermal system for the transcutaneous delivery of levonorgestrel, alone or together with other sex steroid hormones, over a long time period is disclosed. A method of producing the transdermal system that avoids the use of solvents and avoids degradation of the steroid hormones also is disclosed.

Abstract: A transdermal therapeutic system (TTS) for transcutaneous administration of oxybutynin over a period of several days, in addition to a method for the production of the TTS without the use of solvents, are disclosed. The TTS contains a matrix mass containing oxybutynin in the form of a self-adhesive layer. The matrix mass includes ammonium-group-containing (meth)acrylic polymers, at least one citric acid ester, and 5-25 wt. % oxybutynin.

Abstract: This invention provides the use of a silicone-based transdermal therapeutic system having an area of 10 to 40 cm2 and containing 0.1 to 3.15 mg/cm2 of Rotigotine as active ingredient, for the preparation of an anti-Parkinson medicament which effects an improvement, compared to a placebo treatment, of the condition of human Parkinson patients, measured according to the Unified Parkinson's Disease Rating Scale (UPDRS) parts II and III, of 2 units or more following administration for a time period of at least 7 weeks.

Abstract: This invention provides the use of a silicone-based transdermal therapeutic system having an area of 10 to 40 cm2 and containing 0.1 to 3.15 mg/cm2 of rotigotine as active ingredient, for the preparation of an anti-Parkinson medicament which induces a mean plasma concentration of rotigotine in the range of 0.4 to 2 ng/ml 24 h after administration.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for the transcutaneous administration of pergolide over several days and to a method for its manufacture without using solvents. The TTS contains a matrix mass, containing pergolide and taking the form of a layer, which contains a (meth)acrylate copolymer containing ammonio groups or a mixture of a (meth)acrylate copolymer containing amino groups and a (meth)acrylate polymer containing carboxyl groups, 10-50% by weight propylene glycol and up to 5% by weight pergolide.

Abstract: An apparatus, a system and a method are provided for a ring having a hinge and shaped to encompass a finger or other member of an individual as well as a system and method for using the apparatus. The apparatus may have two arc sections. Each arc section may have a cavity located at an end of the arc sections. One of the cavities may have a male portion. The apparatus may also have an ornament. The ornament may have a female portion sized to receive the male portion. The male portion and cavities may support the ornament when the ring is in a closed state. One arc section may be positioned towards a second arc section at the hinge.

Abstract: The pharmaceutical use of nitroglycerin, which is also designated as glycerol trinitrate or, chemically, as 1,2,3-propanetriol trinitrate, in a transdermal application form prevents undesired labour in pregnant mammals. The pharmaceutical use prevents premature labour.

Abstract: A method of preparing a patch for the controlled release of readily available volatile active substances to the skin is disclosed. The patch comprises a back layer, and, bonded to the back layer, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene at a concentration of 10 to 80% by wt., and an active substance at a concentration of 2.5 to 25% by weight, which is a readily volatile liquid at the temperature at which the adhesive bonds.

Abstract: The invention concerns a patch for the controlled release of readily available volatile active substances to the skin, the patch comprising a back layer and, bonded to it, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The patch is characterized in that the pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene (SEBS) at a concentration of 10 to 80% by wt., and an active substance which, at the temperature at which the adhesive bonds, is a readily volatile liquid, and which is present at a concentration of 2.5 to 25% by wt.

Abstract: The invention relates to a dermal plaster for the transdermal provision of nitroglycerin comprising a carrier film and a removable protective film and an adhesive mass containing nitroglycerine on the basis of a cross-linked acrylate-vinyl acetate copolymer in which the monomer mix used for polymerization consists essentially of 21 to 40% wt. vinyl acetate, 55 to 70% wt. of an acrylic acid C2-8 alkyl ester and 3 to 10% wt. of an acrylic acid C2-4 hydroxyalkyl ester and which is cross-linked by heating and the removal of any solvents present after the addition of a cross-linking agent and the nitroglycerin.

Abstract: A process for the continuous production of a rubber compound in a twin-screw extruder is disclosed that improves the dispersion of carbon black in the extrudate while reducing the specific energy requirements of the extrudate. Rubber is fed into the extruder together with a processing aid and masticated up to a temperature of 120.degree. C. to 180.degree. C. Subsequently, a first part of carbon black representing preferably 40% to 80% of the whole quantity of carbon black is fed into the heated extrudate. Afterwards, plasticizing oil is added to the extrudate before the second remaining carbon black part is fed and incorporated into the extrudate at a temperature of 120.degree. C. to 180.degree. C. The whole compound is then cooled, a crosslinking agent is added, and the compound is homogenized and extruded.

Abstract: Known are cutting devices for cutting food products with a base plate, an orbital-driven circular knife, a product feed unit and a counterknife. The invention proposes a height- adjustable distance of the circular knife to the counterknife along the cutting plane, and a stationary counterknife.