Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Low endotoxin fucan compositions comprising a therapeutically effective, medically acceptable fucan in a composition comprising less than about 0.2, 0.18, 0.1, 0.01, 0.001, or 0.0005 endotoxin units (EU) per milligram of the fucan are disclosed. Methods and systems for removing or reducing the amount of endotoxins from a starting fucan composition are also disclosed.

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for providing an application trusted execution environment. Various aspects may include performing attestation of each application enclave of a plurality of application enclaves for a plurality of applications. Aspects may also include receiving a request from a client. Aspects may also include selecting a load balancer to forward the request to the application enclaves. Aspects may also include determining a sensitivity level of the request that is associated with a secured environment parameter. Aspects may include routing, by an enclave server of the load balancer, the request to an application enclave according to the sensitivity level for execution of an application of the plurality of applications in the application trusted execution environment.

Abstract: A beverage production system, comprising a cup dispensing station configured to dispense cups, a beverage dispensing station configured to dispense a beverage, and a turntable assembly. The turntable assembly comprising a central axis, an inner turntable including a first row of cup receptacles, and an outer turntable including a second row of cup receptacles. The outer turntable is disposed circumferentially about the inner turntable, and the outer turntable is configured to rotate about the central axis to align the cup receptacles of the second row with the cup dispensing station and the beverage dispensing station. The turntable assembly is configured to align an opening in a cup receptacle in the second row with an opening in a cup receptacle in the first row. A slide assembly includes an arm configured to slide a cup positioned in the cup receptacle in the second row into the aligned opening of the cup receptacle in the first row.

Abstract: A semiconductor package includes a first die, a second die, and an interconnect die coupled to a first plurality of through-die vias in the first die and a second plurality of through-die vias in the second die. The interconnect die provides communications pathways the first die and the second die.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and a CD38 antibody such as daratumumab. The anti-cancer effect of SIRP?Fc is enhanced in the presence of daratumumab. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgG1 or IgG4 isotype. These combinations are useful particularly to treat blood cancers including lymphomas, leukemias and myelomas.

Abstract: Disclosed is a self-contained mesh radio extension unit, comprising a receiving sleeve having an open volume and a first data connector for communicative coupling to a communication device or cellular phone inserted in the open volume. A low-gain internal antenna and a high-gain external antenna are coupled to a digital data link (DDL) with a first DDL operating frequency. The DDL provides bidirectional internet protocol (IP) connectivity between the first data connector and a peer-to-peer meshed communication network, controlling one or more of the antennae as transceivers at the first DDL operating frequency. An integrated power supply system powers the DDL and includes a rechargeable internal battery and an external power interface. A control system automatically routes IP packets received or transmitted by the DDL and includes a network address translation (NAT) router and an IP addressing service for assigning and tracking IP addresses across the peer-to-peer meshed communication network.

Abstract: Embodiments determine the density of materials and objects imaged using computed tomography (CT). An embodiment co-images a material of unknown density with a calibrant of known density. The digitally reconstructed CT images are segmented into the unknown material phase and the known material phases of the calibrant. Image intensity histograms of the unknown material are obtained. Using the known calibrant densities, an intensity-density mapping is calculated to determine the unknown material density based on its measured CT intensity. The method described herein utilizes a novel deconvolution of the intensity histograms to correct for CT imaging artifacts that impact the material phase intensities. The density of micronized materials and features such as particles, microspheres, porosity, and multiphase composites which are difficult to measure with conventional techniques can be measured using the embodiments.

Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%.

Abstract: A performance measurement indexing system indexes a data store containing data entries indicative of message processing by an application. The application includes a plurality of checkpoints, and the data store contains data logged upon each message traversing the checkpoints in the application. The performance measurement indexing system determines which data entries relate to messages that satisfy a delay condition, and limits queries run on the data store to those data entries, thereby increasing the speed and efficiency with which queries can be serviced.

Abstract: A performance measurement indexing system indexes a data store containing data entries indicative of message processing by an application. The application includes a plurality of checkpoints, and the data store contains data logged upon each message traversing the checkpoints in the application. The performance measurement indexing system determines which data entries relate to messages that satisfy a delay condition, and limits queries run on the data store to those data entries, thereby increasing the speed and efficiency with which queries can be serviced.

Abstract: A liquid dispersing system includes a plate having a plurality of spaced holes passing through the plate. The plate has a thickness, a top portion, and a bottom portion, and each hole comprises a first opening at the top portion of the plate and a second opening at the bottom of the plate. The first opening and the second opening of each hole are differently-sized, so that the holes divide and disperse drops of the liquid into smaller droplets.

Abstract: In accordance with an exemplary embodiment, methods and systems are provided for controlling steering of an autonomous vehicle. The method includes: operating, by a processor, the autonomous vehicle in a semi-automated mode; receiving, by the processor, driver input including a measured driver torque; receiving, by the processor, threat data; determining, by the processor, a steering command bias based on an impedance relation, impedance parameters, the measured driver torque, and the threat data; determining, by the processor, a reference angle based on the steering command bias and a desired angle; and generating, by the processor, control data to control the steering of the autonomous vehicle based on the reference angle.

Abstract: In accordance with an exemplary embodiment, methods and systems are provided for controlling steering of an autonomous vehicle. The method includes: operating, by a processor, the autonomous vehicle in a path-based automated driving assist mode; receiving, by the processor, driver input including a driver torque; classifying, by the processor, an operation mode based on a type of the path-based automated driving assist mode; determining, by the processor, an override threshold for overriding the path-based automated driving assist mode on a first lateral side of the autonomous vehicle based on the operation mode; determining, by the processor, a driver override status based on the override torque threshold; and generating, by the processor, control signals to control the steering of the autonomous vehicle based on the driver override status and the driver torque.

Abstract: A creating and trading system for tokenized open-end fund and a method thereof are disclosed. In the creating and trading system, a fund-end host deploys a smart contract corresponding to an open-end fund in a blockchain network, a performance fee is calculated and a token value is adjusted based on a ROI of an open-end fund, so that when a purchase request of a buyer's host is received, a token is generated based on the token value and the purchase request, and transmitted to a wallet address of the buyer's host, and a register of shareholders in the smart contract is updated; when a transfer request is received, a subscription function and a redemption function of the smart contract are executed to simulate a transfer transaction. Therefore, the fund-end host can centralize the process to avoid a transfer agent, to improve convenience, transparency and liquidity of fund transaction.

Abstract: A multicomponent conductive adhesive barrier includes an adhesive layer and a conductive barrier. The adhesive layer includes a doped pressure-sensitive adhesive and the conductive barrier layer is a carbon or metal-based material. A photoelectrode structure includes a substrate, a photoabsorbing layer, a multicomponent conductive adhesive barrier, and an electrocatalyst. A method for fabricating the photoelectrode structure includes applying a photoabsorbing layer to a substrate, preparing an adhesive layer, and forming a multicomponent conductive adhesive barrier by applying a conductive barrier layer to the adhesive layer.

Abstract: A monitoring system monitors processing of incoming messages by an application, and logs data related to performance of the application. The application includes a plurality of checkpoints, and the monitoring system logs data upon each message traversing the checkpoints in the application. The monitoring system is configured to dynamically modify checkpoints within the application based on latency detection of portions of the application, resulting in improved granularity/resolution of the data collected from congested portions of the application, and reducing the performance penalty of the monitoring system from portions of the application that are not congested.

Abstract: A liquid dispersing system includes a plate having a plurality of spaced holes passing through the plate. The plate has a thickness, a top portion, and a bottom portion, and each hole comprises a first opening at the top portion of the plate and a second opening at the bottom of the plate. The first opening and the second opening of each hole are differently-sized, so that the holes divide and disperse drops of the liquid into smaller droplets.

Abstract: A monitoring system monitors processing of incoming messages by an application, and logs data related to performance of the application. The application includes a plurality of checkpoints, and the monitoring system logs data upon each message traversing the checkpoints in the application. The monitoring system is configured to dynamically modify checkpoints within the application based on latency detection of portions of the application, resulting in improved granularity/resolution of the data collected from congested portions of the application, and reducing the performance penalty of the monitoring system from portions of the application that are not congested.