Abstract: Provided is a method for normalizing embeddings for cross-embedding alignment. The method may include applying mean centering to the at least one embedding set, applying spectral normalization to the at least one embedding set, and/or applying length normalization to the at least one embedding set. Spectral normalization may include decomposing the at least one embedding set, determining an average singular value of the at least one embedding set, determining a respective substitute singular value for each respective singular value of a diagonal matrix, and/or replacing the at least one embedding set with a product of the at least one embedding set, a right singular vector, and an inverse of the substitute diagonal matrix. The mean centering, spectral normalization, and/or length normalization may be iteratively repeated for a configurable number of iterations. A system and computer program product are also disclosed.

Abstract: Data structures, methods and tiling engines for storing tiling data in memory wherein the tiles are grouped into tile groups and the primitives are grouped into primitive blocks. The methods include, for each tile group: determining, for each tile in the tile group, which primitives of each primitive block intersect that tile; storing in memory a variable length control data block for each primitive block that comprises at least one primitive that intersects at least one tile of the tile group; and storing in memory a control stream comprising a fixed sized primitive block entry for each primitive block that comprises at least one primitive that intersects at least one tile of the tile group, each primitive block entry identifying a location in memory of the control data block for the corresponding primitive block. Each primitive block entry may comprise valid tile information identifying which tiles of the tile group are valid for the corresponding primitive block.

Abstract: A method includes receiving a first data set comprising embeddings of first and second types, generating a fixed adjacency matrix from the first dataset, and applying a first stochastic binary mask to the fixed adjacency matrix to obtain a first subgraph of the fixed adjacency matrix. The method also includes processing the first subgraph through a first layer of a graph convolutional network (GCN) to obtain a first embedding matrix, and applying a second stochastic binary mask to the fixed adjacency matrix to obtain a second subgraph of the fixed adjacency matrix. The method includes processing the first embedding matrix and the second subgraph through a second layer of the GCN to obtain a second embedding matrix, and then determining a plurality of gradients of a loss function, and modifying the first stochastic binary mask and the second stochastic binary mask using at least one of the plurality of gradients.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Disclosed are systems and methods for vehicle charging. A charging system can include a component to convey power to a vehicle to charge the vehicle. The charging system can include a module to store a certificate via a cryptographic technique. The charging system can include a data processing system coupled to the module, the data processing system including one or more processors, coupled with memory, to retrieve the certificate from the module, transmit, to a second data processing system, a request to establish a communication connection, the request including the certificate, and establish the communication connection with the second data processing system responsive to a verification of the certificate by the second data processing system. The data processing system can transmit, to the second data processing system, data corresponding to power conveyed by the component to the vehicle subsequent to verification of the certificate.

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract: A sealant spreader device fills voids around a drilled hole with sealant in glued-in-rod (GIR) structures. A liquid sealant may be applied to the base of a drilled hole. A sealant spreader device is then inserted to the base of the drilled hole, through the sealant. The sealant spreader device is then withdrawn while rotating. The sealant spreader device includes winged sections having contours which force the sealant radially outward toward walls of the hole, into any voids around the circumference of the drilled hole, and leaves a thin layer of sealant around the circumference of the drilled hole.

Abstract: Systems and methods determine alignment between a wire and a laser beam in laser joining. A system for checking alignment of a wire relative to a beam of a laser includes a controller configured to align, by tooling, the beam with a sensor system. A laser generates the beam across the wire, with the beam directed to the sensor system. The sensor system measures light intensity of the beam. A processor computes a feature parameter representative of an alignment between the wire and the beam. The processor determines whether the feature parameter is within the process specifications.

Abstract: A data exchange system and method for creating a virtual channel are presented. The data exchange system comprises at least one content provider, at least one content receiver, and a communication platform for connecting the at least one content provider to the at least one content receiver. The communication platform is configured to create a virtual channel for transmitting data between a content provider and a content receiver in response to the content receiver satisfying predefined authentication conditions of the content provider, wherein the virtual channel specifies at least a part of the data to transmit.

Abstract: A thermal processing system for performing thermal processing can include a workpiece support plate configured to support a workpiece and heat source(s) configured to heat the workpiece. The thermal processing system can include window(s) having transparent region(s) that are transparent to electromagnetic radiation within a measurement wavelength range and opaque region(s) that are opaque to electromagnetic radiation within a portion of the measurement wavelength range. A temperature measurement system can include a plurality of infrared emitters configured to emit infrared radiation and a plurality of infrared sensors configured to measure infrared radiation within the measurement wavelength range where the transparent region(s) are at least partially within a field of view the infrared sensors.

Abstract: Provided herein is a combination product comprising a methionine adenosyltransferase II alpha (MAT2A) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The combination product is useful for the treatment of a variety of cancers, including solid tumors. The combination product is useful for the treatment of any number of MAT2A-associated and/or PRMT-associated diseases.

Abstract: A method of implementing administrative services for managing group feedback is disclosed. A selection of a feedback visibility setting for a feedback message from a plurality of predefined feedback visibility settings is received via a give feedback tab of a user interface. The feedback message and a selection of one or more recipients are received via the give feedback tab. The feedback message is sent to the selected one or more recipients based on the selected feedback visibility setting. A request for feedback and a selection of one or more feedback providers are received via a request feedback tab of the user interface. The request for feedback is sent to the selected one or more feedback providers. Received feedback responses linked to a user profile of the feedback requestor are stored.

Abstract: A method of implementing administrative services for managing status updates is disclosed. A status update configuration window is provided on a graphical user interface. The status update configuration window comprises a plurality of update settings for configuring recurring status updates. A selection of update settings is received in the status update configuration window comprising an update frequency, a set of update questions, and a schedule for update reminders. The selected update settings are stored as an update template. An update summary window is displayed concurrently with the status update configuration window. The update summary window comprises a limited list of one or more selectable update management functions. A selection of an update management function is received from the update summary window.

Abstract: The present disclosure is directed to systems and methods that enable scanning of any type of card regardless of the shape and design of a given card and/or a font, a shape and a format with which characters such as numbers, letters and symbols are printed on the cards including cards with non-embossed characters printed thereon. In one example, a method includes scanning a card, the card including at least an account number associated with a user of the card and an identifier of the user; detecting, by applying a machine learning model to the card after scanning the card, at least the account number printed on the card; and completing a task using the account number.

Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.

Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.

Abstract: The present disclosure relates generally to medical devices and, more particularly, to a gas mixing system for a medical ventilator. A gas mixer is provided to adjust the oxygen concentration of environmental air for a blower-based ventilator, by adjusting the mix of air upstream of the ventilator and providing the mixed air to the ventilator's environmental air inlet.

Abstract: Provided are computing systems, methods, and platforms that automatically produce production-ready machine learning models and deployment pipelines from minimal input information such as a raw training dataset. In particular, one example computing system can import a training dataset associated with a user. The computing system can execute an origination machine learning pipeline to perform a model architecture search that selects and trains a machine learning model for the training dataset. Execution of the origination machine learning pipeline can also result in generation of a deployment machine learning pipeline configured to enable deployment of the machine learning model (e.g., running the machine learning model to produce inferences and/or optionally other tasks such as re-training and/or re-tuning the model).

Abstract: Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.