Abstract: Methods, systems, and computer program products for generating, from an input character sequence, an output sequence of audio data representing the input character sequence. The output sequence of audio data includes a respective audio output sample for each of a number of time steps. One example method includes, for each of the time steps: generating a mel-frequency spectrogram for the time step by processing a representation of a respective portion of the input character sequence using a decoder neural network; generating a probability distribution over a plurality of possible audio output samples for the time step by processing the mel-frequency spectrogram for the time step using a vocoder neural network; and selecting the audio output sample for the time step from the possible audio output samples in accordance with the probability distribution.

Abstract: A method for object grasping, including: determining features of a scene; determining candidate grasp locations; determining a set of candidate grasp proposals for the candidate grasp locations; optionally modifying a candidate grasp proposal of the set; determining grasp scores associated with the candidate grasp proposals; selecting a set of final grasp proposals based on the grasp scores; and executing a grasp proposal from the set of final grasp proposals.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, coordinate dynamic adjustments of a trailer based in part on a user profile associated with a user physically present at the trailer and an activity profile associated with an activity selected to be performed at the trailer. A dynamic adjustment may modify a tilt of a lower surface of the trailer. A dynamic adjustment may modify a dimension(s) of the trailer based in part on a detected object(s). Various dynamic adjustments may occur concurrently, individually and/or sequentially. The trailer may be a moveable trailer for temporary attachment with a vehicle.

Abstract: Various embodiments of a trash can assembly (e.g., a receptacle configured to receive refuse, recycleable materials, or otherwise), and related methods, are provided. Some embodiments of the trash can assembly include a body component and a lid configured to move between an open position and a closed position. In some variants, the lid can be moved between the open and closed positions by a power operated driving mechanism, such as a motor and/or other drivetrain components. In certain embodiments, the trash can assembly includes a clutch mechanism to facilitate manual operation of the lid while inhibiting or preventing damage to the motor and/or other drivetrain components.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, coordinate dynamic adjustments of a trailer based in part on a user profile associated with a user physically present at the trailer and an activity profile associated with an activity selected to be performed at the trailer. A dynamic adjustment may modify a tilt of a lower surface of the trailer. A dynamic adjustment may modify a dimension(s) of the trailer based in part on a detected object(s). Various dynamic adjustments may occur concurrently, individually and/or sequentially. The trailer may be a moveable trailer for temporary attachment with a vehicle.

Abstract: A data processing system implements obtaining presentation content for a presentation, the presentation content including a set of slides and a transcript. The system further implements obtaining presentation style information for the presentation from a presentation datastore, generating a prompt for a LLM that includes the transcript and the presentation style information to cause the first LLM to generate an augmented transcript by rewriting the textual cues of the first transcript into a conversational style associated with the presentation style identified in the presentation style information; generating audiovisual content by generating speech for a virtual presenter and generating audiovisual content synchronizing an animation of the virtual presenter with the first audio content, and sending the audiovisual content to the computing devices of users who are in an audience of the presentation.

Abstract: Example data transmission methods and apparatus are described. One example method includes: An access point sends first indication information to a first station, where the first indication information indicates that the first station is accepted to obtain sensing information of a second station. The access point sends the sensing information of the second station to the first station, where the access point is a proxy of the first station, the proxy is configured to obtain the sensing information of the second station for the first station, the first station is a sensing by proxy (SBP) requesting station, and the second station is a SBP responding station.

Abstract: Apparatus for processing substrates can include a gas distribution plate that includes an upper plate and a lower plate and a solid disk between the upper plate and the lower plate. Each of the upper plate and the lower plate has a central region and an outer region surrounding the central region, the central region being solid and the outer region having a plurality of through holes. The upper plate and the lower plate are coaxially aligned along a central axis extending through a center of the central region of the upper plate and a center of the central region of the lower plate. The solid disk is coaxially aligned with the upper plate and the lower plate. The solid disk is configured to block transmission of ultraviolet radiation through the solid disk.

Abstract: A system and computer-implemented method for processing images of a damaged vehicle and estimating a repair cost of the damaged vehicle includes receiving image data of a vehicle from a user mobile device. The image data is processed to determine whether one or more parts of the damaged vehicle are damaged. In addition, one or more parts of the damaged vehicle are identified for repair and one or more parts of the damaged vehicle are identified for replacement. A cost associated for the repair of each of the one or more parts of the damaged vehicle for repair is estimated based on estimated repair cost data contained in a parts repair database. Moreover, a cost associated with the replacement of each of the one or more parts of the damaged vehicle for replacement is determined based on replacement cost data contained in a parts replacement database.

Abstract: Genetically modified microorganisms enabling the simple, rapid production and purification of thermostable polymerases are described. Methods of rapid purification of a thermostable polymerase are described including the steps of autoinducible expression achieving high titers of soluble protein; autolysis of cells post harvest, autohydrolysis of host nucleotides through expression of a thermolabile endonuclease; and heat denaturation and precipitation of contaminating proteins. Polymerases are obtained with >95% purity, and are readily usable in standard PCR.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A multifunctional visualization instrument is provided that, in certain embodiments, includes a body having a proximal end and a distal end. The multifunctional visualization instrument includes a display screen on the body and a camera stick at the distal end of the body and comprising an arm and a camera. The arm of the camera stick is sized to fit within a channel of a removable laryngoscope blade. The multifunctional visualization instrument includes a port on a surface of the laryngoscope, configured to mate with an introducer and a steering input for steering the introducer, displayed on the display screen simultaneously with an image of the patient captured by the camera.

Abstract: A method of detecting and responding to a visitor to a smart home environment via an electronic greeting system of the smart home environment, including determining that a visitor is approaching an entryway of the smart home environment; initiating a facial recognition operation while the visitor is approaching the entryway; initiating an observation window in response to the determination that a visitor is approaching the entryway; obtaining context information from one or more sensors of the smart home environment during the observation window; and at the end of the time window, initiating a response to the detected approach of the visitor based on the context information and/or an outcome of the facial recognition operation.

Abstract: A size of an optical aperture for an imaging system is adjustable. The size of the optical aperture can be adjusted based on refractive index matching, optical absorption, or near field coupling techniques. These techniques may also be used to provide a high speed optical shutter.

Abstract: Techniques are described for multi-task neural network model design using task crystallization are described. In one example a task crystallization method comprises adding one or more task-specific channels to a backbone neural network adapted to perform a primary inferencing task to generate a multi-task neural network model, wherein the adding comprises adding task-specific elements to different layers of the backbone neural network for each channel of the one or more task-specific channels. The method further comprises training, by the system, the one or more task-specific channels to perform one or more additional inferencing tasks that are respectively different from one another and the primary inferencing task, comprising separately tuning and crystallizing the task-specific elements of each channel of the one or more task-specific channels.

Abstract: Provided herein is a combination product comprising a methionine adenosyltransferase II alpha (MAT2A) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The combination product is useful for the treatment of a variety of cancers, including solid tumors. The combination product is useful for the treatment of any number of MAT2A-associated and/or PRMT-associated diseases.

Abstract: Biocatalysts and methods for performing atom transfer radical addition chemistry are described. Generally, modified metalloenzymes are utilized to perform enantioselective and/or diastereoselective atom transfer radical addition chemistry on a broad range of substrates.

Abstract: In an example embodiment, a model is trained to specifically identify reversal points in data and then to rank these reversal points in order of importance. A reversal point shall be defined as a point in which a particular metric, specifically a first order derivative, crosses over from positive to negative or vice-versa. Users are more likely to be interested in abnormal and significant changes in data, and thus the machine-learned model is trained to evaluate a reversal point based on two dimensions: abnormality and significance.

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.