Patents by Inventor Michal Ayalon-Soffer

Michal Ayalon-Soffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparanase splice variant
    Patent number: 9428586
    Abstract: The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: August 30, 2016
    Assignee: COMPUGEN LTD
    Inventors: Ronen Shemesh, Michal Ayalon-Soffer, Zurit Levine, Sergey Nemzer, Tomer Zekharya, Gad S. Cojocaru, Uri Barash, Neta Ilan, Israel Vlodavsky, Iris Hecht
  • METHOD OF TREATING AN ISCHEMIA-REPERFUSION INJURY-RELATED DISORDER BY ADMINISTERING GPCR LIGANDS
    Publication number: 20150005227
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: September 7, 2014
    Publication date: January 1, 2015
    Inventors: YOSSI COHEN, RONEN SHEMESH, AMIR TOPORIK, ZURIT LEVINE, ASSAF WOOL, DVIR DAHARY, IRIS HECHT, GALIT ROTMAN, MICHAL AYALON-SOFFER
  • Method of treating an ischemia-reperfusion injury-related disorder by administering GPCR ligands
    Patent number: 8828940
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 9, 2014
    Assignee: Compugen Ltd.
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Peptide ligands for G-protein coupled receptors
    Patent number: 8349801
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating myocardial and ischemic disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: January 8, 2013
    Assignee: Compugen Ltd.
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Merav Beiman, Galit Rotman, Michal Ayalon-Soffer
  • NOVEL HEPARANASE SPLICE VARIANT
    Publication number: 20120301475
    Abstract: The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
    Type: Application
    Filed: November 30, 2010
    Publication date: November 29, 2012
    Inventors: Ronen Shemesh, Michal Ayalon-Soffer, Zurit Levine, Sergey Nemzer, Tomer Zekharya, Gad S. Cojocaru, Uri Barash, Neta Ilan, Israel Vlodavsky, Iris Hecht
  • Bioactive peptides and method of using same
    Publication number: 20120129776
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: September 18, 2007
    Publication date: May 24, 2012
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Merav Beiman, Galit Rotman, Michal Ayalon-Soffer
  • VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF
    Publication number: 20110212051
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 1, 2011
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Polynucleotides encoding polypeptides and methods using same
    Patent number: 7939634
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Bioactive Peptides and Method of Using Same
    Publication number: 20110104217
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: December 14, 2010
    Publication date: May 5, 2011
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Patent number: 7906635
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 15, 2011
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Peptides which bind to G protein-coupled receptors
    Patent number: 7884180
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 8, 2011
    Assignee: Compugen Ltd
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Patent number: 7842459
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: November 30, 2010
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease
    Publication number: 20100248270
    Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
    Type: Application
    Filed: November 23, 2009
    Publication date: September 30, 2010
    Applicant: Compugen Ltd
    Inventors: Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S. Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh
  • HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME
    Publication number: 20100183573
    Abstract: Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
    Type: Application
    Filed: February 19, 2010
    Publication date: July 22, 2010
    Applicant: COMPUGEN LTD.
    Inventors: Galit Rotman, Merav Beiman, Michal Ayalon-Soffer, Zurit Levine, Chen Hermesh, Anat Oren, Zohar Tiran, Dvir Dahary, Liat Mintz, Hanqing Xie
  • Hepatocyte growth factor receptor splice variants and methods of using same
    Patent number: 7758862
    Abstract: Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: July 20, 2010
    Assignee: Compugen Ltd.
    Inventors: Galit Rotman, Merav Beiman, Michal Ayalon-Soffer, Zurit Levine, Chen Hermesh, Anat Oren, Zohar Tiran
  • MCP-1 SPLICE VARIANTS AND METHODS OF USING SAME
    Publication number: 20100166733
    Abstract: Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
    Type: Application
    Filed: June 21, 2006
    Publication date: July 1, 2010
    Inventors: Zurit Levin, Amir Toporik, Michal Ayalon-Soffer, Iris Hecht, Merav Beiman, Dani Eshel, Tali Handelsman
  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of use Thereof for Diagnosis of Ovarian Cancer
    Publication number: 20100124786
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 20, 2010
    Applicant: Compugen LTD
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
    Publication number: 20100120022
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Application
    Filed: January 27, 2005
    Publication date: May 13, 2010
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
    Patent number: 7714100
    Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 11, 2010
    Assignee: Compugen LTD
    Inventors: Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S. Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh
  • Novel polynucleotides encoding polypeptides and methods using same
    Publication number: 20100075891
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: January 27, 2005
    Publication date: March 25, 2010
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein