Patents by Inventor Michal Ayalon-Soffer

Michal Ayalon-Soffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer
    Publication number: 20100068736
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 18, 2010
    Applicant: Compugen LTD.
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Ayalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • Hepatocyte growth factor receptor splice variants and methods of using same
    Patent number: 7678769
    Abstract: Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: March 16, 2010
    Assignee: Compugen, Ltd.
    Inventors: Galit Rotman, Merav Beiman, Michal Ayalon-Soffer, Zurit Levine, Chen Hermesh, Anat Oren, Zohar Tiran, Dvir Dahary, Liat Mintz, Hanqing Xie
  • NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF BREAST CANCER
    Publication number: 20090286957
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 19, 2009
    Applicant: Compugen LTD
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tavor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • MCP-1 splice variants and methods of using same
    Patent number: 7601692
    Abstract: Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: October 13, 2009
    Assignee: Compugen Ltd.
    Inventors: Zurit Levine, Amir Toporik, Michal Ayalon-Soffer, Iris Hecht, Merav Beiman, Dani Eshel, Tali Handelsman, Sarah Pollock
  • Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer
    Publication number: 20090215046
    Abstract: Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between colon cancer and non-cancerous states.
    Type: Application
    Filed: October 23, 2007
    Publication date: August 27, 2009
    Applicant: COMPUGEN LTD.
    Inventors: Rotem Sorek, Michal Ayalon-Soffer, Dvir Dahary, Amit Novik, Amir Toporik, Alexander Diber, Guy Kol, Sarah Pollock, Zurit Levine, Gad S. Cojocaru, Ronen Shemesh, Yossi Cohen, Osnat Sella-Tavor, Shirley Sameah-Greenwald, Shira Walach
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer
    Patent number: 7569662
    Abstract: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: August 4, 2009
    Assignee: Compugen Ltd
    Inventors: Sarah Pollock, Zurit Levine, Amit Novik, Dvir Dahary, Rotem Sorek, Amir Toporik, Shirley Sameah-Greenwald, Osnat Sella-Tavor, Alexander Diber, Gad S. Cojocaru, Michal Ayalon-Soffer, Shira Walach, Pinchas Akiva, Naomi Keren, Ronen Shemesh
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Patent number: 7553948
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: June 30, 2009
    Assignee: Compugen Ltd
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
    Patent number: 7528243
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: May 5, 2009
    Assignee: Compugen Ltd
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tavor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Bioactive peptides and method of using same
    Publication number: 20090054342
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: September 18, 2007
    Publication date: February 26, 2009
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • ATRIAL NATRIURETIC PEPTIDE (ANP) SPLICE VARIANTS AND METHODS OF USING SAME
    Publication number: 20090035287
    Abstract: Novel ANP polypeptides and polynucleotides encoding same are provided. Also provided are methods and pharmaceutical compositions which can be used to treat ANP-related diseases and disorders including cardiovascular disorders using the polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: September 26, 2006
    Publication date: February 5, 2009
    Inventors: Zurit Levine, Michal Ayalon-Soffer, Merav Beiman, Ronen Shemesh
  • HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME
    Publication number: 20090036374
    Abstract: Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 5, 2009
    Inventors: Galit Rotman, Merav Beiman, Michal Ayalon-Soffer, Zurit Levine, Chen Hermesh, Anat Oren, Zohar Tiran
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer
    Publication number: 20090004648
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Application
    Filed: March 6, 2007
    Publication date: January 1, 2009
    Applicant: COMPUGEN LTD.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Novel brain natriuretic peptide variants and methods of use thereof
    Publication number: 20080182299
    Abstract: Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 31, 2008
    Applicant: COMPUGENT LTD.
    Inventors: Gad S. Colocaru, Alexander Diber, Amit Novik, Sarah Pollock, Zurit Levine, Yossi Cohen, Michal Ayalon-Soffer
  • HEPATOCYTE GROWTH FACTOR RECEPTOR SPLICE VARIANTS AND METHODS OF USING SAME
    Publication number: 20080159992
    Abstract: Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
    Type: Application
    Filed: July 23, 2007
    Publication date: July 3, 2008
    Applicant: COMPUGEN LTD.
    Inventors: Galit Rotman, Merav Beiman, Michal Ayalon-Soffer, Zurit Levine, Chen Hermesh, Anat Oren, Zohar Tiran, Dvir Dahary, Liat Mintz, Hanqing Xie
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer
    Patent number: 7368548
    Abstract: Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 6, 2008
    Assignee: Compugen Ltd.
    Inventors: Dvir Dahary, Sarah Pollock, Zurit Levine, Rotem Sorek, Michal Ayalon-Soffer, Pinchas Akiva, Amir Toporik, Osnat Sella-Tavor, Shirley Sameah-Greenwald
  • Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
    Patent number: 7345142
    Abstract: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: March 18, 2008
    Assignee: Compugen Ltd.
    Inventors: Yossi Cohen, Alexander Diber, Amir Toporik, Sarah Pollock, Zurit Levine, Michal Ayalon-Soffer, Gad S. Cojocaru, Amit Novik, Guy Kol, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Dvir Dahary, Ronen Shemesh
  • Brain natriuretic peptide spliced variant
    Patent number: 7332569
    Abstract: Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 19, 2008
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Alexander Diber, Amit Novik, Sarah Pollock, Zurit Levine, Yossi Cohen, Michal Ayalon-Soffer
  • Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer
    Publication number: 20070259386
    Abstract: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
    Type: Application
    Filed: February 28, 2007
    Publication date: November 8, 2007
    Applicant: COMPUGEN LTD.
    Inventors: Amir Toporik, Dvir Dahary, Rotem Sorek, Sarah Pollock, Zurit Levine, Pinchas Akiva, Alexander Diber, Amit Novik, Osnat Sella-Tayor, Michal Ayalon-Soffer, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Naomi Keren, Maxim Shklar
  • Novel thrombospondin-1 polynucleotides encoding variant thrombospondin-1 polypeptides and methods using same
    Publication number: 20070219125
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and phamaceutical compositions which can be used to treat various disorders such as cancer and retinopathies, using the polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: February 23, 2007
    Publication date: September 20, 2007
    Inventors: Gad Cojocaru, Zurit Levine, Michal Ayalon-Soffer, Amir Toporik, Sarah Pollock, Galit Rotman, Merav Beiman
  • MCP-1 splice variants and methods of using same
    Publication number: 20070092484
    Abstract: Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
    Type: Application
    Filed: June 21, 2006
    Publication date: April 26, 2007
    Inventors: Zurit Levine, Amir Toporik, Michal Ayalon-Soffer, Iris Hecht, Merav Beiman, Dani Eshel, Tali Handelsman, Sarah Pollock