Abstract: It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients.

Abstract: It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (300) comprises a base element (302), a radiation source (305), which is formed at the base element (302) and which is adapted to emit electromagnetic radiation (306), an optical element (325), which is arranged at the base element (302) and which is adapted to interact with the electromagnetic radiation (306). The transducer device (300) further comprises a radiation detector (350), which is adapted to receive the electromagnetic radiation (326) having interacted with the optical element (325), and a hydrogel material (340), which is mechanically coupled to the optical element (325) and which is adapted to change its volume when getting into contact with an environmental material of the transducer device (300) such that the spatial position of the optical element (325) is changed.

Abstract: The present invention relates to a cosmetic process for caring for human skin, intended to moisturize it and/or to protect it against drying out, comprising the topical application to the skin of a composition containing at least one active agent that stimulates the expression of the matriptase MT/SP1. It also relates to the cosmetic use of such an active agent for moisturizing human skin and/or protecting it against drying out. It further relates to the use of such an active agent to manufacture a pharmaceutical composition intended to prevent and/or alleviate skin tautness, stinging and/or itching and/or lip chapping. The active agents are extracts of Ceratonia siliqua, Cananga odorata hook, Cedrelopsis grevei and Cistus ladaniferus L.

Abstract: The invention relates to a system for driving a fuel pump in a turbine engine, said system comprising an electric motor and fluid flow assistance means controlled by a control valve. In said system, the control valve is a regulator valve the opening of which is controlled as a function of information representative of the speed of the pump, and/or the speed of the turbine engine, and/or the flow rate of fuel delivered to the turbine engine. As a result, operating safety of the turbine engine can be increased in the event of the electric motor failing or of its electricity generator failing, and the weight/size/cost ratios of the drive system are improved.

Abstract: The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion.

Abstract: An implantable drug delivery system is proposed which does not need internal electronics, but can be activated from outside the body. The system comprises a device (10) for the controlled release of a substance, the device (10) comprising at least one compartment (20) in a substrate (11), the compartment (20) being closed by a valve (30), wherein the valve is openable and comprises at least a first material (31) and a second material (32), the opening and/or closing of the valve (30) being provided upon heating and/or cooling of the first and/or second material (31, 32), the first material (31) being heated by electromagnetic induction.

Abstract: The invention relates to a device for medical treatment decision support and/or monitoring the status of a patient, the device comprising a first measuring means at the ipsilateral side and a second measuring means at the contralateral side and a comparison means in order to find the optimal and/or suboptimal time for drug treatment and/or other medical treatment steps.

Abstract: The present invention relates to an improved method for manufacturing (meth)acrylic anhydride by transanhydrization between (meth)acrylic acid and acetic anhydride, in the presence of air and in the presence of at least one polymerization inhibitor, characterized in that the polymerization inhibitor is chosen from the group formed from (a) metal salts of thiocarbamic or dithiocarbamic acid and their mixtures with a phenolic derivative or phenothiazine and its derivatives, and (b) N-oxyl compounds as a mixture with 2,6-di-tert-butyl-4-methylphenol taken alone or in the presence of 2,4-dimethyl-6-tert-butylphenol.

Abstract: The compounds of formula (I) are provided as deposition inhibitors which prevent the deposition of compounds of polymeric nature or resulting from addition reactions to (meth)acrylic double bonds during operations for the synthesis or purification or regeneration of (meth)acrylic monomers. R1 represents a C3-C30 alkyl radical, an aryl radical or an alkylaryl radical, it being possible for these radicals to be interrupted by or connected to the oxygen of the molecule via a —(OR4)o— chain where the R4 groups each independently represent an ethylene, propylene or butylene chain and o is an integer from 1 to 50; R2 represents R1, a hydrogen atom or a counterion; and R3 represents a hydrogen atom or a counterion.

Abstract: The invention relates to an osmotic pump (1) comprising at least one chargeable material (30) whereby the osmotic pressure is caused by inducing and/or de-inducing charges within the material.

Abstract: The present invention relates to a pixelated electroluminescent textile, comprising a first set of spaced apart conductive lines extending in a first direction, a second set of spaced apart conductive lines extending in a second direction, the second direction being non-parallel to the first direction, the sets of conducting lines forming a matrix structure, and at least one light emitting element. The at least one light emitting element comprises two interleaving comb electrodes arranged in one plane, and light emitting means arranged in spaces between digits of the comb electrodes, wherein the light emitting element is arranged in an area formed between two adjacent conductive lines in the first set and two adjacent conductive lines in the second set, wherein each of the comb electrodes connects to at least one yarn of the first and the second set, respectively, so that when applying a driving voltage to the at least one yarn in the first and second sets, said light emitting means is excited to emit light.

Abstract: The invention relates to a micropump comprising at least one gas releasing material which drives a piston towards a second material containing a drug material which is released through a semi permeable membrane and/or flow restrictor

Abstract: The invention relates to a device (1) for magnetic resonance imaging of a body (7) placed in a stationary and substantially homogeneous main magnetic field. In order to provide an MR device (1) which is arranged to automatically select an optimum subsampling scheme for three-dimensional SENSE, the invention proposes to select the subsampling scheme such that the maximum number of folded-over image values is minimized and simultaneously distances between the positions of the folded-over image values within the predetermined field of view are maximized.

Abstract: This invention provides a device for the controlled release of a substance and a method of controllably releasing a substance from a compartment.

Abstract: The invention relates to a device for drug administration and/or monitoring the status of a patient, said device comprising at least one measuring means for measuring at least one body parameter of a patient for at least ?1 measuring cycle, the measuring means being located in or in the vicinity of a bio-implantable and/or bio-implementable needle.

Abstract: The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter.

Abstract: Light-emitting diode (LED) comprising a translucent substrate of ?-Al2O3 or SiC and a first layer of a light-emitting semiconductor material grown on a first side of said substrate, a first electrode and a second electrode, wherein said substrate is polycrystalline. The average grain size of the polycrystalline substrate is preferably of the same order as the wavelength of the light emitted by the semiconductor material during use of the LED.

Abstract: A method of manufacturing a component having a three-dimensional structure in a surface region, includes:—a step of forming a substantially solid layer (13) of material, which step comprises the steps of applying a substantially fluid composition over a surface, and—a step of removing an intermediate composition (12), impervious to at least a component of the substantially fluid composition and occupying at least part of the three-dimensional structure when the substantially fluid composition has at least partially set. The step of forming the substantially solid layer (13) of material is preceded by the steps of—providing a structure including recessed parts (5 to 7) on a surface of a substantially solid further layer (3), and—applying the intermediate composition (12) so as at least partially to fill at least the recessed parts (5 to 7) of the structure on the surface of the substantially solid further layer (3).

Abstract: The present invention relates to a flexible display device (10) comprising a flexible substrate (12), and a plurality of electro-optical switching elements (14) accommodated on the substrate. The device is characterized in that the substrate has a plurality of through openings (16) being arranged in a repetitive pattern so that the electro-optical switching elements are located in areas of the substrate adjacent to the openings. The through openings allow for bending the display device in two directions simultaneously, with reduced tensile or compressive stress in the plane of the substrate.

Abstract: A light-source comprising at least one lighting unit (101) being arranged on a substrate (102) and a diffusing element (103) being arranged to receive and diffuse light emitted by said at least one lighting unit (101) is provided. The diffusing element (103) comprises a layer of non-woven fabric having a lower density at a side facing the lighting unit and a higher density at a side opposite to the lighting unit to obtain good diffusing properties.