Patents by Inventor Michel J. N. Cormier

Michel J. N. Cormier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduction or prevention of sensitization to drugs
    Patent number: 5149539
    Abstract: The present invention is directed to a method of reducing or preventing skin sensitization by inhibiting the immunological processing of a sensitizing drug as an antigen. The drug is sensitizing to humans, i.e., the drug is susceptible to inducing skin or mucosa sensitization in a human when the drug is transdermally administered to the human at a therapeutically effective rate. Skin sensitization reduction or prevention is induced by coadministering to the skin or mucosa of the human:(a) a therapeutically effective amount of a sensitizing drug, at a therapeutically effective rate over a predetermined period of time; and(b) an antigen processing-inhibiting agent in an amount effective to inhibit the antigen processing of the drug.The system of the invention comprises a matrix adapted to be placed in sensitizing drug and antigen processing-inhibiting agent transmitting relation to the selected skin or mucosa site.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: September 22, 1992
    Assignee: ALZA Corporation
    Inventors: Philip W. Ledger, Michel J. N. Cormier, Alfred Amkraut
  • Reduction or prevention of skin irritation by drugs
    Patent number: 5130139
    Abstract: The present invention provides a method of reducing or preventing skin irritation of a weak base drug by inhibiting the accumulation of the drug in the lysosomes. The drug is irritating to humans, i.e., the drug is susceptible to inducing skin or mucosa irritation in a human when the drug is transdermally administered to the human at a therapeutically effective rate. Irritation reduction or prevention is induced by coadministering to the skin or mucosa of the human:(a) a therapeutically effective amount of a weak base drug which is irritating to humans, at a therapeutically effective rate over a predetermined period of time; and(b) an effective amount of an agent capable of inhibiting the lysosomal uptake of the drug to reduce or prevent irritation to the skin or mucosa.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: July 14, 1992
    Assignee: Alza Corporation
    Inventors: Michel J-N Cormier, Philip W. Ledger, Alfred Amkraut
  • Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
    Patent number: 4885154
    Abstract: A method and means for reducing sensitization or irritation caused by transdermally delivered drugs, wherein one or more metabolic modulators is coadministered with a sensitizing or irritating drug.
    Type: Grant
    Filed: March 1, 1988
    Date of Patent: December 5, 1989
    Assignee: Alza Corporation
    Inventors: Michel J. N. Cormier, Philip W. Ledger, Alfred Amkraut, Jean P. Marty