Patents by Inventor Michel Joseph

Michel Joseph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8440686
    Abstract: The present invention relates to ester prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse and alcohol dependence and impulse control disorders such as pathological gambling and addiction to shopping.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: May 14, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michel Joseph Maurice André Guillaume, Tim Gaekens
  • Patent number: 8283795
    Abstract: A system in an electric vehicle converts the mechanical energy resulting from movement of the vehicle chassis to electric energy. The system has one or more energy conversion units including an alternator with a rotatable shaft and a weighted fly wheel fixed to the shaft. A female receptor on an end of the alternator shaft is disposed in spaced, axial alignment with a male driver on the end of a spiral ratcheting shaft that is operatively engaged with a pivoting lever and the chassis of the vehicle, whereupon upward and downward motion of the chassis frame causes the male driver to move between engagement and disengagement with the female receptor. A ratchet mechanism drives rotation of the spiral ratcheting shaft upon engagement of the male driver with the female receptor, thereby rotating the female receptor, flywheel and alternator shaft.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 9, 2012
    Inventors: Michel Joseph Khoury, Vasa Jovanov
  • Publication number: 20120147381
    Abstract: A system includes an optical source. The system further includes a reflective sensor remotely deployed from the optical source. The system further includes an optical processor. The system further includes a forward optical waveguide spanning the distance from, and transmitting light from, the optical source to the reflective sensor. The system further includes a return optical waveguide spanning the distance from, and transmitting light from, the reflective sensor to the optical processor. The forward optical waveguide follows substantially the same path as, but is completely separate from, the return optical waveguide.
    Type: Application
    Filed: August 20, 2009
    Publication date: June 14, 2012
    Inventors: Michel Joseph LeBlanc, Etienne Marcel Samson
  • Patent number: 8143432
    Abstract: The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for regioselective diol mono-tosylation, wherein Y is selected from the group of C1-6alkyl, phenyl and benzyl. The concentration of the generic acetal compound of Formula (Ic) is less than about 2 mol %, preferably ranges between about 2 mol % and about 0.0005 mol %, preferably ranges between about 0.1 mol % and about 0.005 mol %.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: March 27, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michel Joseph Maurice André Guillaume, Yolande Lydia Lang
  • Patent number: 7967746
    Abstract: A rectoscope has a tube and a handle protruding therefrom. A number of light-emitting elements are arranged circumferentially distributed at the distal end of the tube. The tube includes an inner pipe, an outer pipe and an annular body at the distal ends of the inner and outer pipe. The annular body includes an end ring provided with bores for receiving the light-emitting elements. The annular body also includes an annular flange extending away proximally and having an outside diameter corresponding to a clear inside diameter of the outer pipe. The end ring has an outside diameter corresponding approximately to an outside diameter of the outer pipe.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: June 28, 2011
    Assignee: Karl Storz GmbH & Co. KG
    Inventors: Joel Jules Louis Leroy, Jacques Francois Bernard Marescaux, Didier Raoul Daniel Mutter, Michel Joseph Emile Vix
  • Patent number: 7955292
    Abstract: The invention relates to an endosurgical extraction bag for collecting body tissue or body fluid, with a bag main part formed from a flexible envelope, and with a first admission opening for introducing tissue or fluid into the bag main part of the bag. Arranged in the bag main part, there is an inner envelope which is connected to the main part (bag) and opens toward the first admission opening, but adjoins the bag main part sealingly in respect of the first admission opening, and which has a second admission opening at its second end remote from the first admission opening and spaced apart from an end of the bag main part remote from the first admission opening, through which second admission opening the tissue or fluid can be introduced into the bag main part.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: June 7, 2011
    Assignee: MTP Medical Technical Promotion GmbH
    Inventors: Joel Jules Louis Leroy, Jacques Francois Bernard Marescaux, Didier Raoul Daniel Mutter, Michel Joseph Emile Vix
  • Publication number: 20110053971
    Abstract: The present invention relates to prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse and alcohol dependence and impulse control disorders such as pathological gambling and addiction to shopping.
    Type: Application
    Filed: April 23, 2009
    Publication date: March 3, 2011
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Michel Joseph Maurice André Guillaume, Tim Gaekens
  • Publication number: 20110034502
    Abstract: The present invention relates to ester prodrugs of nalmefene of formula (I), pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of substance abuse disorders such as alcohol abuse and alcohol dependence and impulse control disorders such as pathological gambling and addiction to shopping.
    Type: Application
    Filed: April 23, 2009
    Publication date: February 10, 2011
    Inventors: Michel Joseph, Maurice, Andre Guillaume, Tim Gaekens
  • Patent number: 7871807
    Abstract: The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: January 18, 2011
    Assignee: Sanofi Pasteur, S.A.
    Inventors: Catherine Gerdil, Catherine Moste, Isabelle Legastelois, Michel Joseph Marie Bublot, Francois-Xavier Le Gros
  • Publication number: 20100314887
    Abstract: A system in an electric vehicle converts the mechanical energy resulting from movement of the vehicle chassis to electric energy. The system has one or more energy conversion units including an alternator with a rotatable shaft and a weighted fly wheel fixed to the shaft. A female receptor on an end of the alternator shaft is disposed in spaced, axial alignment with a male driver on the end of a spiral ratcheting shaft that is operatively engaged with a pivoting lever and the chassis of the vehicle, whereupon upward and downward motion of the chassis frame causes the male driver to move between engagement and disengagement with the female receptor. A ratchet mechanism drives rotation of the spiral ratcheting shaft upon engagement of the male driver with the female receptor, thereby rotating the female receptor, flywheel and alternator shaft.
    Type: Application
    Filed: June 11, 2010
    Publication date: December 16, 2010
    Inventors: Michel Joseph Khoury, Vasa Jovanov
  • Publication number: 20100251645
    Abstract: A buck for use with concrete form systems, such as insulated concrete forms and the like, is provided. The buck is particularly suitable for an opening in an insulated concrete form and comprises a main section having first and second ends, the first end for attaching to a first panel in the insulated concrete form, an angle section having first and second ends, the first end connected to the main section and the second end of the angle section for attaching to a second panel of the insulated concrete form, for providing an angle between the angle section and the main section, wherein at least one of the main section and the angle section is disposed non-perpendicularly from the first panel or second panel.
    Type: Application
    Filed: October 29, 2008
    Publication date: October 7, 2010
    Applicant: Phil -Insul Corporation
    Inventor: Michel Joseph Rene Philippe
  • Publication number: 20100016623
    Abstract: The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for regioselective diol mono-tosylat ion, wherein Y is selected from the group of C1-6alkyl, phenyl and benzyl. The concentration of the generic acetal compound of Formula (Ic) is less than about 2 mol %, preferably ranges between about 2 mol % and about 0.0005 mol %, preferably ranges between about 0.1 mol % and about 0.005 mol %.
    Type: Application
    Filed: November 9, 2007
    Publication date: January 21, 2010
    Inventors: Michel Joseph Maurice Guillaume, Yolande Lydia Lang
  • Publication number: 20090308011
    Abstract: An insulated concrete form (ICF) panel reinforcement is disclosed. The ICF comprises a main panel, a reinforcement on the main panel for stiffening the main panel, a spacer retention element integrated in the reinforcement for securing a spacer to the panel, and a first opposing panel opposite the main panel and having a first opposing spacer retention element integrated therein for securing the spacer to the first opposing panel. The ICF panel reinforcement is particularly useful at high stress locations in ICF systems, such as at T-wall intersections.
    Type: Application
    Filed: July 13, 2007
    Publication date: December 17, 2009
    Applicant: PHIL-INSUL CORPORATION
    Inventor: Michel Joseph Rene Philippe
  • Patent number: 7470809
    Abstract: The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis(2-methoxyethoxy)aluminate (Red-Al) to the corresponding alcohol; d) chlorinating the alcohol obtained in step c); e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2): f1) reacting the product obtained in step d) with sodium cyanide; f2) hydrolysing the product obtained in step f1).
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: December 30, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michel Joseph Maurice André Guillaume, Yolande Lydia Lang, Armin Roessler, Lars Ulmer, Stefan Marcel Herman Leurs, Dirk De Smaele
  • Publication number: 20070213556
    Abstract: The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis(2-methoxyethoxy)aluminate (Red-Al) to the corresponding alcohol; d) chlorinating the alcohol obtained in step c); e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2): f1) reacting the product obtained in step d) with sodium cyanide; f2) hydrolysing the product obtained in step f1).
    Type: Application
    Filed: August 26, 2005
    Publication date: September 13, 2007
    Inventors: Michel Joseph Guillaume, Yolande Lang, Armin Roessler, Lars Ulmer, Stefan Leurs, Dirk De Smaele
  • Publication number: 20070093692
    Abstract: A rectoscope has a tube and a handle protruding therefrom. A number of light-emitting elements are arranged circumferentially distributed at the distal end of the tube.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 26, 2007
    Inventors: Joel Leroy, Jacques Francois Bernard Marescaux, Didier Raoul Mutter, Michel Joseph Vix
  • Patent number: 7071469
    Abstract: A process and an apparatus are useful for identifying articles which are at least partly made from at least one polymer. The process and apparatus use an optical spectrometer and a transport system, whereby the articles to be identified are moved by the transport system past the optical spectrometer, where they are irradiated, response measured and analyzed. An external reference object is also transported, by the transport system, past the optical spectrometer such that it becomes possible to use the measured response for the reference object to identify, with greater accuracy, the articles to be identified.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: July 4, 2006
    Assignee: DSM IP Assets B.V.
    Inventors: Antonius Christianus Berghmans, Michel Joseph Germain Huys
  • Patent number: 6998494
    Abstract: The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: February 14, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Yolande Lydia Lang, Bart Petrus Anna Maria Jozef Medaer, Georges Joseph Cornelius Hoornaert, Thierry Brossette, Frans Josef Cornelius Compernolle, Michel Joseph Maurice André Guillaume, Hua Mao, Tomasz Kozlecki
  • Patent number: 6969457
    Abstract: An electrochemical process for selectively stripping at least one coating from the surface of a substrate is disclosed. The substrate (often a turbine engine component) is immersed in a composition through which electrical current flows. The composition includes a halide salt, such as sodium chloride, ammonium chloride, and potassium chloride. In preferred embodiments, the electrical current is direct current (DC). The process is especially useful for selectively removing portions of diffusion aluminide coatings. For example, the additive layer can efficiently be removed, without substantially affecting the underlying diffusion layer or substrate. Related stripping compositions and apparatuses are also described.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: November 29, 2005
    Assignee: General Electric Company
    Inventors: Leo Spitz MacDonald, Bin Wei, Michel Joseph Shaw, John Robert LaGraff, Warren Davis Grossklaus, Stephen Joseph Ferrigno, Tris Colaizzi
  • Publication number: 20050240018
    Abstract: The present invention relates to a novel process, suitable for industrial exploitation for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, also known as N-lidocaine, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine. The process comprises the consecutive steps a) through f) a) reacting piperazine with N-haloacetyl-2,6-xylidine in a molar ratio between about 1/1 and about 6/1 in an aqueous solvent in which has been dissolved an equimolar amount of HCl; b) separating the solid formed in step a) from the reaction mixture; c) neutralizing the filtrate; d) extracting the filtrate with a solvent which is not or only to a small extent miscible with the aqueous solvent mentioned in step a); e) crystallizing the N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide from the solvent mentioned in step d) and f) separating the solid obtained in step e) from the solvent mentioned in step d).
    Type: Application
    Filed: June 19, 2003
    Publication date: October 27, 2005
    Inventors: Michel Joseph Maurice Guillaume, Josef Ludo Jan Cuypers, Ivan Joseph Maria Vervest, Stefan Marcel Herman Leurs, Dirk De Smaele