Abstract: Compounds of formula I: ##STR1## in which: n=1-4,R represents hydrogen, halogen, alkyl, hydroxyl or alkoxy, R.sub.1 represents a radical --NHCOR2 (A.sub.1); (in which R.sub.2 represents alkyl, cycloalkyl, phenyl optionally substituted-, -O-alkyl, 3-pyridyl, 2-pyrrolyl, quinolyl, 1-isoquinolyl, 2-thienyl or 3-indolyl); a radical of --NHSO2R3 (A.sub.2) (in which R.sub.3 represents alkyl, cycloalkyl or phenyl optionally substituted); a radical --NHCONHR4 (A.sub.3) (in which R.sub.4 represents alkyl or phenyl-optionally substituted); a phthalimido radical (A.sub.4); an o-sulfobenzoic imido radical (A.sub.5); a di(benzoyl)amino radical (A.sub.6) optionally substituted; a radical of formula A.sub.7 : ##STR2## (in which R.sub.5 represents carbamoyl, cyano, carboxy or alkoxycarbonyl); or a radical of formula A.sub.8 : ##STR3## their stereoisomers and their addition salts with a pharmaceutically-acceptable inorganic or organic acid, are disclosed to be useful as 5-HT.sub.

Abstract: Compounds of formula I: ##STR1## in which: n=1-4;R represents hydrogen, halogen, alkyl, hydroxyl or alkoxy, R.sub.1 represents a radical --NHCOR2 (A.sub.1); (in which R.sub.2 represents alkyl, cycloalkyl, phenyl optionally substituted-, --O-alkyl, 3-pyridyl, 2-pyrrolyl, quinolyl, 1-isoquinolyl, 2-thienyl or 3-indolyl); a radical of --NHSO2R3 (A.sub.2) (in which R.sub.3 represents alkyl, cycloalkyl or phenyl optionally substituted); a radical --NHCONHR4 (A.sub.3) (in which R.sub.4 represents alkyl or phenyl-optionally substituted); a phthalimido radical (A.sub.4); an o-sulfobenzoic imido radical (A.sub.5); a di(benzoyl)amino radical (A.sub.6) optionally substituted; a radical of formula A.sub.7 : ##STR2## (in which R.sub.5 represents carbamoyl, cyano, carboxy or alkoxycarbonyl); or a radical of formula A.sub.8 : ##STR3## their stereoisomers and their addition salts with a pharamaceutically-acceptable inorganic or organic acid, are disclosed to be useful as 5-HT.sub.

Abstract: Compounds of the formula I: ##STR1## in which: n=1-4,R represents hydrogen, halogen, alkyl, hydroxyl or alkoxy, R.sub.1 represents a radical --NHCOR2 (A.sub.1); (in which R.sub.2 represents alkyl, cycloalkyl, phenyl optionally substituted-, --O-alkyl, 3-pyridyl, 2-pyrrolyl, quinolyl, 1-isoquinolyl, 2-thienyl or 3-indolyl); a radical of --NHS02R3 (A.sub.2) (in which R.sub.3 represents alkyl, cycloalkyl or phenyl optionally substituted); a radical --NHCONHR4 (A.sub.3) (in which R.sub.4 represents alkyl or phenyl-optionally substituted); a phthalimido radical (A.sub.4); an o-sulfobenzoic imido radical (A.sub.5); a di(benzoyl)amino radical (A.sub.6) optionally substituted; a radical of formula A.sub.7 : ##STR2## (in which R.sub.5 represents carbamoyl, cyano, carboxy or alkoxycarbonyl); or a radical of formula A.sub.8 : ##STR3## their stereoisomers and their addition salts with a pharmaceutically-acceptable inorganic or organic acid, are disclosed to be useful as 5-HT.sub.

Abstract: The invention relates to compounds of formula I: ##STR1## in which m=2-4,n and p, which may be identical or different, are an integer equal to 1, 2 or 3, with the proviso that the sum of n and pq=0 or 1,R is a 1,2,3,4-tetrahydro-2,4-dioxo-3-quinazolinyl radical, optionally substituted, a 1,3,4,6,11,11a-hexahydro-1,3-dioxo-2H-pyrazino[1,2-b]isoquinol-2-yl radical, a 1,2-dihydro-1-oxo-2-phthalazinyl radical, optionally substituted, a 2,6-dioxo-1-piperazinyl radical of formula W: ##STR2## (R.sub.3 is a 2-pyridyl radical or an optionally substituted phenyl radical),a radical of formula Z: ##STR3## (R.sub.4 is a carbamoyl radical, a cyano radical, a hydroxycarbonyl radical or an alkoxycarbonyl radical having 1 to 6 carbon atoms),or a radical of formula Y: ##STR4## (R.sub.5 is a 2-pyrimidinyl radical, a 1-isoquinolyl radical, a 2-quinolyl radical, a 2-pyridyl radical, a benzyl radical, optionally substituted, a 2-thiazolyl radical, optionally substituted, or a 2-benzothiazolyl radical) andeither R.sub.1 and R.sub.

Abstract: The invention relates to the compounds of general formula I: ##STR1## in which: m represents an integer from 2 to 4,n and p, which may be identical or different, each represent an integer from 1 to 3,q represents 0 or 1, andR represents:either a group of formula (A): ##STR2## or a radical of formula (B): ##STR3## or a 2,4-dioxo-1,2,3,4-tetrahydroquinazolinyl radical, on condition, however, that, in this case, n and p do not simultaneously represent the number 2,or a benzhydryloxy group,or a 1-oxophthalazinyl radical,or a 5-oxothiazolo[3,2-A]pyrimidinyl radical,or a group of formula C: ##STR4## their possible stereoisomers and their addition salts with a pharmaceutically acceptable inorganic or organic acid.The compounds of formula I are medicinal products with useful 5-HT.sub.2 - and .alpha..sub.1 -antagonistic activities.

Abstract: The invention relates to compounds of formula I: ##STR1## in which m=2-4,n and p, which may be identical or different, are an integer equal to 1, 2 or 3, with the proviso that the sum of n and p is 5,q=0 or 1,R is a 1,2,3,4-tetrahydro-3-quinazolinyl radical, optionally substituted, a 1,3,4,6,11,11a-hexahydro-1,3-dioxo-2H-pyrazino[1,2-b]isoquinol-2-yl radical, a 1,2-dihydro-1-oxo-2-phthalazinyl radical, optionally substituted, a 2,6-dioxo-1-piperazinyl radical of formula W: ##STR2## (R.sub.3 is a 2-pyridyl radical or an optionally substituted phenyl radical),a radical of formula Z: ##STR3## (R.sub.4 is a carbamoyl radical, a cyano radical, a hydroxycarbonyl radical or an alkoxycarbonyl radical having 1 to 6 carbon atoms),or a radical of formula Y: ##STR4## (R.sub.5 is a 2-pyrimidinyl radical, a 1-isoquinolyl radical, a 2-quinolyl radical, a 2-pyridyl radical, a benzyl radical, optionally substituted, a 2-thiazolyl radical, optionally substituted, or a 2-benzothiazolyl radical) andeither R.sub.1 and R.sub.

Abstract: The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted with one or more halogen atoms,X denotes a hydrogen atom, a linear or branched lower alkyl group or a group SO.sub.2 E in which E denotes a linear or branched lower alkyl group or an aryl group optionally substituted with a linear or branched lower alkyl group,T denotes a hydrogen atom or a lower alkyl group,R.sub.3 denotes a hydrogen atom or a linear or branched lower alkyl group or an aryl group optionally substituted with one or more linear or branched lower alkyl groups,n and m, which may be identical or different, each denote 0 or 1,R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group,or alternatively,R.sup.1 and R.sup.

Abstract: Compounds of formula (I): ##STR1## in which E denotes a lower alkyl group, or preferably a hydrogen atom, and their addition salts with a pharmaceutically acceptable acid or base, the preparation thereof and pharmaceutical compositions containing them.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as thereapeutic drugs.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract: Disubstituted polymethylene imines of the formula: ##STR1## in which: A is a straight or branched chain (C.sub.3 -C.sub.5) hydrocarbon containing radical optionally containing one or two double bond and optionally substituted by one or more hydroxy;n is zero, one or two;Z is oxygen or NH; andR is:either COR', in which R' is:(a) a straight or branched chain (C.sub.1 -C.sub.6), hydrocarbon containing radical, optionally containing one oxygen or sulfen or a double bond and optionally substituted by phenyl or substituted phenyl; or(b) phenyl, halophenyl, lower alkoxyphenyl, (di-or-tri-methylene) dioxyphenyl or;(c) furyl, thienyl, benzofuryl, benzothienyl or benzodioxannyl; or(d) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or lower alkyl or ##STR3## is a five or six membered heterocyclic radical which may contain an oxygen;or--SO.sub.2 R" in which R" is (C.sub.1 -C.sub.3) alkyl or phenyl.

Abstract: Compounds of the formula: ##STR1## in which: R.sub.1 and R.sub.2 each represent, independently of one another, hydrogen, halogen, alkyl or alkoxy having from 1 to 4 carbon atoms, sulphonamide possibly substituted by an alkyl radical having from 1 to 4 carbon atoms; or together methylenedioxy, n is 0 or 1,in racemic form or in the form of optical isomers, and also their salts of addition with pharmaceutically acceptable acids. Useful in the treatment of ailments and/or conditions which are adrenoreceptor-related, such relationship being well known in the art.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract: Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH;B is CH or a nitrogen atom;m is 2 or 3;X--Y-- represents --CH.dbd.CH--(CR'R").sub.n - in which n is zero or 1, and R' and R" are hydrogen or methyl;Z is oxygen or sulfur,R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, andT is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia.

Abstract: Polymethylene-imines of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5 in a straight or branched chain possibly containing one or two double bonds and possibly substituted by one or more hydroxy radicals;X is CH or nitrogen;n is zero, one or two;Y is oxygen or N--R.sub.1 in which R.sub.1 is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, cycloalkyl or cycloalkenyl from C.sub.3 to C.sub.7, or acetyl;R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.5 to C.sub.7 or phenyl optionally substituted by one or more fluorine or chlorine; andB is hydrogen, alkyl from C.sub.1 to C.sub.5, alkenyl from C.sub.2 to C.sub.5, or phenyl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, .DELTA.3-chromanyl, thiochromenyl or chromanyl, each optionally substituted by fluorine, chlorine, alkyl or alkoxy from C.sub.1 to C.sub.5 ; ora radical of the formula: ##STR2## in which: R.sub.2, R.sub.3 and R.sub.

Abstract: N,N'-substituted polymethylene diamines of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5 in a straight or branched chain optionally containing one and two double bonds and possibly substituted by one or more hydroxy radicals;X is CH or nitrogen;n is an integer from 2 to 6;R.sub.1 is hydrogen, or alkyl from C.sub.1 to C.sub.5 ;R.sub.2 is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.5 to C.sub.7, or phenyl optionally substituted by one or more fluorine or chlorine, andB is:phenyl, naphthyl, benzofuranyl, benzothionyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, .DELTA.3-chromenyl, thiochromenyl or chromanyl, each of them optionally substituted by fluorine, chlorine, alkyl or alkoxy from C.sub.1 to C.sub.5, or methylene-dioxy, ora radical of the formula: ##STR2## in which R.sub.3, R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen or phenyl optionally substituted by fluorine or chlorine.

Abstract: Compounds of the general formula: ##STR1## wherein: the ring A is saturated and n=0 or 1, orthe ring A is a benzene ring and n=1,R.sub.1 represents a lower alkyl group which can carry an amino group,R.sub.2 represents a hydrogen atom or a lower alkyl group,R.sub.3 represents a straight or branched alkyl group, a mono- or di-cycloalkylalkyl or phenylalkyl group having no more than a total of 9 carbon atoms, or a substituted alkyl group, and also the salts thereof.These compounds are useful as therapeutic drugs.

Abstract: Piperazine and homopiperazine compounds of the formula: ##STR1## in which: A is a hydrocarbon radical from C.sub.3 to C.sub.5, in a straight or branched chain, which may contain one or two double bonds, and optionally substituted by one or more OH;B is CH or a nitrogen atom;m is 2 or 3;X--Y-- represents --CH.dbd.CH-- (CR'R").sub.n -- in which n is zero or 1, and R' and R" are hydrogen or methyl;Z is oxygen or sulfur,R is hydrogen, alkyl from C.sub.1 to C.sub.5, cycloalkyl from C.sub.3 to C.sub.7, or phenyl optionally substituted by fluorine, chlorine or alkyl from C.sub.1 to C.sub.5, andT is hydrogen, fluorine, chlorine or alkyl from C.sub.1 to C.sub.5.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxy.