Abstract: A data management system (DMS) may receive an indication of a configuration for a quorum-based authorization (QAuth) policy that controls interactions between two or more users and a security cloud service of the DMS. The configuration may include a policy scope for the QAuth policy, protected actions that trigger the QAuth policy, and compute objects to which the QAuth policy is assigned. The DMS may receive an instruction to assign a set of role-based access control (RBAC) permissions associated with the QAuth policy to a first user. The DMS may receive a request to perform a protected action on at least one compute object to which the QAuth policy is assigned. In response to the request, the DMS may trigger a two-person rule (TPR) enforcement mechanism of the QAuth policy by requesting approval from the first user with the set of RBAC permissions.

Abstract: A method for updating configuration settings of a backup database supported by a data management system is described. The method may include receiving, from a first user in a first user group, a request to update configuration settings of the backup database. The method may further include determining that the first user is authorized to update the configuration settings of the backup database based on a set of permissions associated with the first user. The method may further include identifying a second user in a second user group that is authorized to approve the request from the first user. The method may further include transmitting an indication of the request to the second user and receiving a notification that the second user has approved the request from the first user. The method may further include updating the configuration settings of the backup database in response to the notification.

Abstract: Embodiments of the present invention include systems and methods for dynamically moderating gameplay content according to speech patterns of a user. The system may receive one or more audio segments set over a communication network from a user device, where the audio segments include recorded communications associated with a user of the user device. This may include monitoring a gameplay session of the user device, where one or more gameplay interactions within a virtual environment are detected in the gameplay session. Using a machine-learning model, one or more inferences regarding the user may be generated based upon the audio segments and the detected gameplay interactions. A set of moderation parameters, based on the user inferences, may be generated by the machine-learning model. The system may modify content within the virtual environment of the gameplay session according to the set of moderation parameters.

Abstract: A method for updating configuration settings of a backup database supported by a data management system is described. The method may include receiving, from a first user in a first user group, a request to update configuration settings of the backup database. The method may further include determining that the first user is authorized to update the configuration settings of the backup database based on a set of permissions associated with the first user. The method may further include identifying a second user in a second user group that is authorized to approve the request from the first user. The method may further include transmitting an indication of the request to the second user and receiving a notification that the second user has approved the request from the first user. The method may further include updating the configuration settings of the backup database in response to the notification.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: Provided is a method of contacting a subject, cell, or tissue with an amphiphilic block copolymer to treat a viral infection. The resulting effect can be treating a disease caused by a virus, inhibiting viral replication, inhibiting an unfolded protein response of a virus, preventing death of tissue infected by a virus, or promoting cell repair and recovery to increase survival of cells infected by a virus. The hydrophobic block of the amphiphilic block copolymer binds to an exposed hydrophobic domain of the virus. Further provided is an amphiphilic block copolymer comprising three or more hydrophobic substituents or an alkylene spacer on a hydrophobic block of the copolymer.

Abstract: In some implementations, a vehicle experience system may receive a service request associated with a vehicle. The vehicle experience system may qualify a driver for a vehicle experience involving the vehicle. The vehicle experience system may provide, to a user device associated with the driver, a verification code for authenticating the vehicle experience involving the driver and the vehicle. The vehicle experience system may provide, to a location management system associated with the vehicle, a notification that the vehicle is to be involved in the vehicle experience. The vehicle experience system may provide, to the location management system and based on receiving scan data being associated with the verification code, the authentication of the vehicle experience to enable a provisioning device to facilitate access to the vehicle.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: A method for updating configuration settings of a backup database supported by a data management system is described. The method may include receiving, from a first user in a first user group, a request to update configuration settings of the backup database. The method may further include determining that the first user is authorized to update the configuration settings of the backup database based on a set of permissions associated with the first user. The method may further include identifying a second user in a second user group that is authorized to approve the request from the first user. The method may further include transmitting an indication of the request to the second user and receiving a notification that the second user has approved the request from the first user. The method may further include updating the configuration settings of the backup database in response to the notification.

Abstract: In some implementations, a vehicle experience system may receive a service request associated with a vehicle. The vehicle experience system may qualify a driver for a vehicle experience involving the vehicle. The vehicle experience system may provide, to a user device associated with the driver, a verification code for authenticating the vehicle experience involving the driver and the vehicle. The vehicle experience system may provide, to a location management system associated with the vehicle, a notification that the vehicle is to be involved in the vehicle experience. The vehicle experience system may provide, to the location management system and based on receiving scan data being associated with the verification code, the authentication of the vehicle experience to enable a provisioning device to facilitate access to the vehicle.

Abstract: Provided herein are methods of genetically editing cells with large DNA templates using a non-viral editing method. Also provided herein are cells comprising at least one large DNA template non-virally inserted into a target region of the genome of the cell.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: In some implementations, a vehicle experience system may receive a service request associated with a vehicle. The vehicle experience system may qualify a driver for a vehicle experience involving the vehicle. The vehicle experience system may provide, to a user device associated with the driver, a verification code for authenticating the vehicle experience involving the driver and the vehicle. The vehicle experience system may provide, to a location management system associated with the vehicle, a notification that the vehicle is to be involved in the vehicle experience. The vehicle experience system may provide, to the location management system and based on receiving scan data being associated with the verification code, the authentication of the vehicle experience to enable a provisioning device to facilitate access to the vehicle.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Abstract: A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.